128272-26-4

Basic information

• Product Name: METHYL 2-FLUORO-4-METHOXYBENZOATE
• Synonyms: METHYL 2-FLUORO-4-METHOXYBENZOATE;RARECHEM AL BF 0456
• CAS NO: 128272-26-4
• Molecular Formula: C₉H₉FO₃
• Molecular Weight: 184.16
• Product Categories: Acids & Esters;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds
• Mol File: 128272-26-4.mol

Chemical Properties

• Boiling Point: 250.1 °C at 760 mmHg
• Flash Point: 102.1 °C
• Appearance: /
• Density: 1.184 g/cm³
• Vapor Pressure: 0.022mmHg at 25°C
• Refractive Index: 1.486
• CAS DataBase Reference: METHYL 2-FLUORO-4-METHOXYBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-FLUORO-4-METHOXYBENZOATE(128272-26-4)
• EPA Substance Registry System: METHYL 2-FLUORO-4-METHOXYBENZOATE(128272-26-4)

Safety Data

• Hazardous Substances Data: 128272-26-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 2-FLUORO-4-METHOXYBENZOATE is used as a chemical intermediate for the synthesis of various organic compounds, particularly in drug development. Its unique functional groups allow for the creation of new pharmaceutical agents with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical sector, METHYL 2-FLUORO-4-METHOXYBENZOATE serves as an intermediate in the production of crop protection agents. Its properties can be leveraged to develop compounds that protect crops from pests and diseases, thereby enhancing agricultural productivity.
Used in Organic Synthesis Research:
METHYL 2-FLUORO-4-METHOXYBENZOATE is utilized as a building block in organic synthesis, allowing researchers to explore new chemical reactions and create novel compounds with diverse applications in various industries.

InChI:InChI=1/C9H9FO3/c1-12-6-3-4-7(8(10)5-6)9(11)13-2/h3-5H,1-2H3

Upstream product

• 67-56-1 methanol 
• 394-42-3 2-fluoro-4-methoxy-benzoic acid 
• 865-33-8 potassium methanolate 
• 106614-28-2 methyl 2,4-difluorobenzoate 
• 865-34-9 lithium methanolate 
• 124-41-4 sodium methylate 

Downstream Products

• 405-09-4 (2-fluoro-4-methoxyphenyl)methanol 
• 949465-86-5 5-methyl 5-bromo-2-fluoro-4-methoxybenzoate 
• 1290181-04-2 3-(2-fluoro-4-methoxyphenyl)-3-oxopropanenitrile 
• 1290181-50-8 tert-butyl 4-(4-(3-(tert-butoxycarbonylamino)-5-cyano-6-(2-fluoro-4-methoxyphenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-4-yl)phenyl)piperazine-1-carboxylate 

Relevant articles and documents

Ortho-selectivity in SNAr substitutions of 2,4-dihaloaromatic compounds. Reactions with anionic nucleophiles

The nucleophilic addition of organic anions to aromatic compounds with halogens positioned both ortho and para to activating groups was studied in a variety of solvents. Substrates showed strong preferences for ortho substitution in most cases. Evidence is presented for activating group-dependent coordination, which contributes to very high ortho-selectivity in nonpolar solvents. This also drives the overall reaction rate in these solvents, and is of close to the same magnitude of rate increase derived from polar solvents. para-Products are maximized by using crown ethers in protic solvents. Solvent effects overall are very different from corresponding reactions with amine nucleophiles due primarily to the different charges present in the transition states, and to solvation of the nucleophile.

Regioselective SNAr reactions of substituted difluorobenzene derivatives: practical synthesis of fluoroaryl ethers and substituted resorcinols

In this Letter, we describe a practical and highly selective method for the preparation of fluoroaryl ethers and differentially substituted resorcinol derivatives. This synthetic strategy relies on a selective SNAr of substituted difluorobenzen

METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND

The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Spe