128900-19-6Relevant articles and documents
New Supported β-Amino Alcohols as Efficient Catalysts for the Enantioselective Addition of Diethylzinc to Benzaldehyde under Flow Conditions
Burguete, M. Isabel,Garcia-Verdugo, Eduardo,Vicent, Maria J.,Luis, Santiago V.,Pennemann, Helmut,Graf Von Keyserling, Nikolai,Martens, Jurgen
, p. 3947 - 3950 (2007/10/03)
(Matrix Presented) Polymeric monoliths 10 containing an amino alcohol moiety derived from an industrial waste material represent one of the best ligands for the enantioselective catalytic addition of ZnEt2 to benzaldehyde (99% ee), being recove
Chemical differentiation of enantiotopic groups: Diastereoselective opening of a prochiral dilactone
Deseke, Eckart,Hoyer, Wolfgang,Winterfeldt, Ekkehard
, p. 14577 - 14598 (2007/10/03)
Prochiral dilactone 1 has been synthesized and subjected to diastereoselective nucleophilic opening. The structural features of chiral, enantiomerically pure nucleophiles have been optimized regarding their capability to perform prochiral recognition at dilactone 1. 3-Ketoglutaric mono acid products 2 of dilactone opening, which are versatile building blocks for natural product synthesis, have been obtained in diastereomeric ratios up to 84:16 and were enriched by subsequent crystallization to 97.5:2.5.
Utilization of Industrial Waste Materials, 1. - Synthesis of New Primary and Secondary Chiral 1,2-Diamines
Stingl, Klaus,Martens, Juergen
, p. 243 - 250 (2007/10/02)
Primary and secondary 1,2-diamines with three or four stereogenic centers were synthesized starting from the benzyl ester of the bicyclic proline analogue (all-R)-2-azabicyclooctane-3-carboxylic acid by a four- or five-step procedure.This is an example for the utilization of the industrial waste material (all-R)-2b. - Key Words: 1,2-Diamines / 2-Azabicyclooctanes / Proline analogue / Cyclopentapyrroles
TANDEM GENERATION AND INTRAMOLECULAR TRAPPING OF CHIRAL STABILISED AZOMETHINE YLIDS WITH ALKYNE DIPOLAROPHILES
Harwood, Laurence M.,Kitchen, Lara C.
, p. 6603 - 6606 (2007/10/02)
Due to steric contraints imposed upon the bridging chain by the three-carbon linear unit associated with the alkyne, hex-5-ynal condenses with (5R)-phenylmorpholin-2-one (1) and undergoes intramolecular 3+2 dipolar cycloaddition via the syn-azomethine yli
Derivatives of bicyclic aminoacids agents containing these compounds and their use
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, (2008/06/13)
Disclosed are cis, exo- and trans-compounds of the formula I STR1 in which n denotes 0, 1 or 2, R1 denotes hydrogen, (C1 -C6)-alkyl which can optionally be substituted by amino, (C1 -C4)-acyl- or bezoylamino, (C2 -C6)-alkenyl, (C5 -C9)-cycloalkyl, (C5 -C9)-cycloalkenyl, (C5 -C7)-cycloalkyl-(C1 -C4)-alkyl, aryl or partially hydrogenated aryl, which can, in each case, be substituted by (C1 -C2)-alkyl, (C1 -C2)-alkoxy or halogen, aryl-(C1 -C4)-alkyl, /which can be substituted as defined previously in the aryl radical/, a monocyclic or bicyclic sulfur or nitrogen and/or nitrogen heterocyclic radical, or a side chain of naturally occurring aminoacid, R2 denotes hydrogen, (C1 -C6)-alkyl, (C2 -C6)-alkenyl or aryl-(C1 -C4)-alkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen, X denotes (C1 -C6)-alkyl, (C2 -C6)-alkenyl, (C6 -C9)-cycloalkyl or aryl which can be mono-, di- or tri- substituted by (C1 -C4)-alkyl, (C1 -C4)-alkoxy, hydroxyl, halogen, nitro, amino, (C1 -C4)-alkylamino, di-(C1 -C4 -alkylamino or methylenedioxy, or indol-3-yl, or physiologically acceptable salts thereof, a process of the preparation thereof, agents containing them, their use as a medicine and intermediates for the preparation thereof.
COUPLING OF β-ACETAMIDO RADICALS WITH α-CHLORO ACRYLONITRILE - A NEW ACCESS TO DISUBSTITUTED PROLINE DERIVATIVES
Henning, R.,Urbach, H.
, p. 5343 - 5346 (2007/10/02)
β-Acetamido radicals are prepared by reduction of organomercurials and coupled with α-chloro-acrylonitrile.The coupling products are further converted to proline derivatives.