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6-Trifluoromethyl-pyridine-2-carbaldehyde is an organic compound characterized by the presence of a trifluoromethyl group at the 6th position and a formyl group at the 2nd position on a pyridine ring. It is a valuable intermediate in the synthesis of various complex molecules and pharmaceuticals due to its unique structural features and reactivity.

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  • 6-(Trifluoromethyl)-2-pyridinecarboxaldehyde 6-(Trifluoromethyl)picolinaldehyde

    Cas No: 131747-65-4

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  • 131747-65-4 Structure
  • Basic information

    1. Product Name: 6-Trifluoromethyl-pyridine-2-carbaldehyde
    2. Synonyms: 6-Trifluoromethyl-pyridine-2-carbaldehyde;6-(trifluoroMethyl)pyridin-2-carbaldehyde;6-(trifluoroMethyl)picolinaldehyde;2-Formyl-6-(trifluoromethyl)pyridine, 6-(Trifluoromethyl)picolinaldehyde;6-(Trifluoromethyl)pyridine-2-carboxaldehyde;6-(Trifluoromethyl)-2-pyridinecarboxaldehyde;2-(Trifluoromethyl)pyridine-6-carbaldehyde;6-((trifluoromethyl))-2-Pyridinecarbaldehyde
    3. CAS NO:131747-65-4
    4. Molecular Formula: C7H4F3NO
    5. Molecular Weight: 175.11
    6. EINECS: N/A
    7. Product Categories: organic building block
    8. Mol File: 131747-65-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 168.7 °C at 760 mmHg
    3. Flash Point: 75℃
    4. Appearance: /
    5. Density: 1.369 g/cm3
    6. Vapor Pressure: 1.6mmHg at 25°C
    7. Refractive Index: 1.476
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: 1.06±0.10(Predicted)
    11. CAS DataBase Reference: 6-Trifluoromethyl-pyridine-2-carbaldehyde(CAS DataBase Reference)
    12. NIST Chemistry Reference: 6-Trifluoromethyl-pyridine-2-carbaldehyde(131747-65-4)
    13. EPA Substance Registry System: 6-Trifluoromethyl-pyridine-2-carbaldehyde(131747-65-4)
  • Safety Data

    1. Hazard Codes: T
    2. Statements: 25-36/37/38-43
    3. Safety Statements: 26-36/37-45
    4. RIDADR: UN 2811 6.1 / PGIII
    5. WGK Germany: 3
    6. RTECS:
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 131747-65-4(Hazardous Substances Data)

131747-65-4 Usage

Uses

Used in Pharmaceutical Industry:
6-Trifluoromethyl-pyridine-2-carbaldehyde is used as a key intermediate for the synthesis of [1,2,3]triazolo[1,5-a]pyridines, which are important classes of compounds with potential applications in the development of new drugs. These compounds exhibit a range of biological activities, including anti-cancer, anti-inflammatory, and anti-microbial properties.
Used in Chemical Synthesis:
6-Trifluoromethyl-pyridine-2-carbaldehyde is used as a versatile building block for the synthesis of various complex organic molecules, particularly those containing the trifluoromethyl and pyridine moieties. Its reactivity and stability make it a valuable component in the development of new materials and compounds with diverse applications.
Used in Medicinal Chemistry:
6-Trifluoromethyl-pyridine-2-carbaldehyde is used as a starting material for the development of triple T-type calcium channel blockers. These blockers are important in the treatment of various cardiovascular diseases, such as hypertension and angina, by selectively inhibiting the T-type calcium channels, which play a crucial role in the regulation of heart rate and blood pressure.

Check Digit Verification of cas no

The CAS Registry Mumber 131747-65-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,7,4 and 7 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 131747-65:
(8*1)+(7*3)+(6*1)+(5*7)+(4*4)+(3*7)+(2*6)+(1*5)=124
124 % 10 = 4
So 131747-65-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H4F3NO/c8-7(9,10)6-3-1-2-5(4-12)11-6/h1-4H

131747-65-4 Well-known Company Product Price

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  • Aldrich

  • (761737)  6-(Trifluoromethyl)pyridine-2-carboxaldehyde  

  • 131747-65-4

  • 761737-1G

  • 1,233.18CNY

  • Detail

131747-65-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-(Trifluoromethyl)-2-pyridinecarboxaldehyde 6-(Trifluoromethyl)picolinaldehyde

1.2 Other means of identification

Product number -
Other names 6-(trifluoromethyl)pyridine-2-carbaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:131747-65-4 SDS

131747-65-4Relevant articles and documents

AROMATIC HETEROCYCLIC COMPOUND, INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF

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Paragraph 0218; 0221-0222, (2021/02/05)

Disclosed are an aromatic heterocyclic compound, an intermediate thereof, a preparation method therefor, and a pharmaceutical composition and use thereof. The aromatic heterocyclic compound of the present invention is a new ALK5 inhibitor, and is used for treating and/or preventing various ALK5-mediated diseases.

NOVEL OXALYL PIPERAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

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Page/Page column 118; 119, (2020/11/12)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

NOVEL INDOLIZINE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

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Page/Page column 122; 123, (2020/11/12)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

Copper-mediated perfluoroalkylation of heteroaryl bromides with (phen)CuRF

Mormino, Michael G.,Fier, Patrick S.,Hartwig, John F.

, p. 1744 - 1747 (2014/04/17)

The attachment of perfluoroalkyl groups onto organic compounds has been a major synthetic goal over the past several decades. Previously, our group reported phenanthroline-ligated perfluoroalkyl copper reagents, (phen)CuR F, which react with aryl iodides and aryl boronates to form the corresponding benzotrifluorides. Herein the perfluoroalkylation of a series of heteroaryl bromides with (phen)CuCF3 and (phen)CuCF 2CF3 is reported. The mild reaction conditions allow the process to tolerate many common functional groups. Perfluoroethylation with (phen)CuCF2CF3 occurs in somewhat higher yields than trifluoromethylation with (phen)CuCF3, creating a method to generate fluoroalkyl heteroarenes that are less accessible from trifluoroacetic acid derivatives.

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