1620-72-0

Basic information

• Product Name: CHEMPACIFIC 38183
• Synonyms: CHEMPACIFIC 38183;2-METHYL-6-TRIFLUOROMETHYL-PYRIDINE;6-METHYL-2-TRIFLUOROMETHYL-PYRIDINE
• CAS NO: 1620-72-0
• Molecular Formula: C₇H₆F₃N
• Molecular Weight: 161.12
• Mol File: 1620-72-0.mol

Chemical Properties

• Melting Point: 12.5 °C
• Boiling Point: 127.4°C at 760 mmHg
• Flash Point: 30.9°C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 13.5mmHg at 25°C
• Refractive Index: 1.429
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.27±0.12(Predicted)
• CAS DataBase Reference: CHEMPACIFIC 38183(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMPACIFIC 38183(1620-72-0)
• EPA Substance Registry System: CHEMPACIFIC 38183(1620-72-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 1620-72-0(Hazardous Substances Data)

Usage

Uses

Used in Automotive Industry:
CHEMPACIFIC 38183 is used as a cleaning agent for removing dirt, grease, and other contaminants from automotive parts and machinery. Its powerful solvent blend ensures that components are thoroughly cleaned, enhancing performance and extending the life of the equipment.
Used in Aerospace Industry:
In the aerospace industry, CHEMPACIFIC 38183 is utilized as a degreasing agent for cleaning and maintaining aircraft components. Its ability to remove stubborn oils and residues ensures that aircraft parts function optimally and are free from potential hazards caused by accumulated contaminants.
Used in Manufacturing Industry:
CHEMPACIFIC 38183 is employed as a heavy-duty cleaner in manufacturing facilities to remove oils, greases, and other contaminants from machinery and equipment. Its effectiveness in cleaning various surfaces helps maintain the efficiency and longevity of the machinery used in the production process.
Used in Maintenance and Repair Shops:
CHEMPACIFIC 38183 is used as a versatile cleaner in maintenance and repair shops for heavy machinery and equipment. Its ability to dissolve and lift away tough residues makes it an essential tool for ensuring that machinery is thoroughly cleaned and ready for operation or further repair work.
It is crucial to handle CHEMPACIFIC 38183 with care and follow proper safety measures during its use, as it may pose risks if not managed correctly.

InChI:InChI=1/C7H6F3N/c1-5-3-2-4-6(11-5)7(8,9)10/h2-4H,1H3

Upstream product

• 1574-41-0 Z-piperylene 
• 353-85-5 trifluoroacetonitrile 
• 109-06-8 α-picoline 
• 75-63-8 Bromotrifluoromethane 
• 5315-25-3 2-bromo-6-methylpyridine 
• 2314-97-8 iodotrifluoromethane 
• 108-88-3 toluene 
• 77152-08-0 trifluoromethylcopper(I) 
• 676-58-4 methylmagnesium chloride 
• 39890-95-4 2-chloro-6-trifluoromethylpyridine 
• 75-24-1 trimethylaluminum 
• 1824-81-3 2-Amino-6-methylpyridine 

Downstream Products

• 131747-42-7 6-(trifluoromethyl)pyridine-2-carboxylic acid 
• 131747-65-4 6-(trifluoromethyl)-2-pyridinecarboxaldehyde 
• 131747-53-0 [6-(trifluoromethyl)pyridin-2-yl]methanol 
• 108337-80-0 2,6-dimethyl-4-(6-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester 
• 1321515-80-3 6-[2-methyl-6-(trifluoromethyl)pyridin-4-yl]-5-phenyl-1,2,4-triazin-3-amine 
• 781637-62-5 2-(bromomethyl)-6-(trifluoromethyl)pyridine 

Relevant articles and documents

CRYSTAL FORM AND SALT TYPE OF TRIAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREOF

Disclosed in the present invention are a crystal form of a [1,2,4]triazolo[1,5-c]pyrimidine compound and a preparation method thereof. Further disclosed is a use of the crystal form in the preparation of a medicament for treating A2A receptor r

NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS II

The invention relates novel NK1 Receptor antagonists represented in formula (A), wherein R1 and R2 independently are selected from the group consisting of (C1-4)alkyl, (C1-4)haloalkyl, (C1-4) alkoxy, CD3 or halogen; R3 is selected from the group consisting of hydrogen, (C1-4)alkyl, (C1-4)haloalkyl and (C1-4)hydroxyalkyl; R4 is selected from the group consisting of phenyl, 5-membered heteroaryl and 6-membered heteroaryl; R5 and R6 are independently selected from the group consisting of hydrogen, (C1-4)alkyl, (C1-4)hydroxyalkyl and (C1-4)haloalkyl and X and Y are independently selected from the group consisting of CH and N. The invention furthermore relates to intermediates for the preparation of said compounds, to their use in therapy, and to pharmaceutical compositions comprising said compounds.

NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS II

The invention relates novel NK1 receptor antagonists represented in formula A, wherein R1 and R2 independently are selected from the group consisting of (C1-4)alkyl, (C1-4)haloalkyl, (C1-4)alkoxy, CD

Copper-mediated perfluoroalkylation of heteroaryl bromides with (phen)CuRF

The attachment of perfluoroalkyl groups onto organic compounds has been a major synthetic goal over the past several decades. Previously, our group reported phenanthroline-ligated perfluoroalkyl copper reagents, (phen)CuR F, which react with aryl iodides and aryl boronates to form the corresponding benzotrifluorides. Herein the perfluoroalkylation of a series of heteroaryl bromides with (phen)CuCF3 and (phen)CuCF 2CF3 is reported. The mild reaction conditions allow the process to tolerate many common functional groups. Perfluoroethylation with (phen)CuCF2CF3 occurs in somewhat higher yields than trifluoromethylation with (phen)CuCF3, creating a method to generate fluoroalkyl heteroarenes that are less accessible from trifluoroacetic acid derivatives.

Trifluoromethylation of aryl and heteroaryl halides with fluoroform-derived CuCF3: Scope, limitations, and mechanistic features

Fluoroform-derived CuCF3 recently discovered in our group exhibits remarkably high reactivity toward aryl and heteroaryl halides, performing best in the absence of extra ligands. A broad variety of iodoarenes undergo smooth trifluoromethylation with the ligandless CuCF3 at 23-50 C to give the corresponding benzotrifluorides in nearly quantitative yield. A number of much less reactive aromatic bromides also have been trifluoromethylated, including pyridine, pyrimidine, pyrazine, and thiazole derivatives as well as aryl bromides bearing electron-withdrawing groups and/or ortho substituents. Only the most electrophilic chloroarenes can be trifluoromethylated, e.g., 2-chloronicotinic acid. Exceptionally high chemoselectivity of the reactions (no side-formation of arenes, biaryls, and C2F5 derivatives) has allowed for the isolation of a large number of trifluoromethylated products in high yield on a gram scale (up to 20 mmol). The CuCF3 reagent is destabilized by CuX coproduced in the reaction, the magnitude of the effect paralleling the Lewis acidity of CuX: CuCl > CuBr > CuI. While SNAr and SRN1 mechanisms are not operational, there is a well-pronounced ortho effect, i.e., the enhanced reactivity of ortho-substituted aryl halides 2-RC6H4X toward CuCF3. Intriguingly, this ortho-effect is observed for R = NO2, COOH, CHO, COOEt, COCH3, OCH3, and even CH3, but not for R = CN. The fluoroform-derived CuCF3 reagent and its reactions with haloarenes provide an unmatched combination of reactivity, selectivity, and low cost.

Reactions of Trifluoromethyl Bromide and Related Halides: Part 10. Perfluoroalkylation of Aromatic Compounds induced by Sulphur Dioxide Radical Anion Precursors

Perfluoroalkylation of electron-rich aromatic compounds with trifluoromethyl bromide, or long-chain perfluoroalkyl iodides, was performed in the presence of sodium dithionite or zinc-sulphur dioxide.This alkylation occurred at the ortho and para positions relative to the amino or hydroxy substitutent.Pyrroles were perfluoroalkylated regioselectively at the 2-position.This alkylation was interpreted as a radical aromatic substitution; the formation of the perfluoroalkyl radical can be induced by a single-electron transfer from sulphur dioxide radical anion to the perfluoroalkyl halide.

Process for perfluoroalkylation of aromatic derivatives

A process for the perfluoroalkylation of aromatic derivatives. In a first stage, an aromatic derivative, sulfur dioxide and a metal selected from the group consisting of zinc, aluminum, manganese, cadmium, magnesium, tin, iron, nickel and cobalt, are brought into contact in a solvent, preferably a polar aprotic solvent. In a second stage, a perfluoroalkyl bromide or iodide is added to react with the aromatic derivative.