1620-72-0

Basic information

• Product Name: CHEMPACIFIC 38183
• Synonyms: CHEMPACIFIC 38183;2-METHYL-6-TRIFLUOROMETHYL-PYRIDINE;6-METHYL-2-TRIFLUOROMETHYL-PYRIDINE
• CAS NO: 1620-72-0
• Molecular Formula: C₇H₆F₃N
• Molecular Weight: 161.12
• Mol File: 1620-72-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 12.5 °C
• Boiling Point: 127.4°C at 760 mmHg
• Flash Point: 30.9°C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 13.5mmHg at 25°C
• Refractive Index: 1.429
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.27±0.12(Predicted)
• CAS DataBase Reference: CHEMPACIFIC 38183(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMPACIFIC 38183(1620-72-0)
• EPA Substance Registry System: CHEMPACIFIC 38183(1620-72-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 1620-72-0(Hazardous Substances Data)

Usage

General Description

CHEMPACIFIC 38183 is a chemical mixture commonly used as an industrial cleaner and degreaser. It is a high-performance solvent blend that effectively removes oils, greases, and other stubborn contaminants from metal and machinery surfaces. The ingredients of CHEMPACIFIC 38183 may include solvents such as isopropyl alcohol, ethylbenzene, and n-methylpyrrolidone, among others, which work together to dissolve and lift away tough residues. This versatile cleaner is often used in automotive, aerospace, and manufacturing industries, as well as in maintenance and repair shops for heavy machinery and equipment. It is important to use this chemical product with caution and follow proper safety measures as it may be harmful if not handled properly.

InChI:InChI=1/C7H6F3N/c1-5-3-2-4-6(11-5)7(8,9)10/h2-4H,1H3

Upstream product

• 75-63-8 Bromotrifluoromethane 
• 108-88-3 toluene 
• 75-24-1 trimethylaluminum 
• 39890-95-4 2-chloro-6-trifluoromethylpyridine 
• 676-58-4 methylmagnesium chloride 
• 5315-25-3 2-bromo-6-methylpyridine 
• 77152-08-0 trifluoromethylcopper(I) 
• 353-85-5 trifluoroacetonitrile 
• 1824-81-3 2-Amino-6-methylpyridine 
• 2314-97-8 iodotrifluoromethane 
• 109-06-8 α-picoline 
• 1574-41-0 Z-piperylene 

Downstream Products

• 131747-42-7 6-(trifluoromethyl)pyridine-2-carboxylic acid 
• 131747-65-4 6-(trifluoromethyl)-2-pyridinecarboxaldehyde 
• 131747-53-0 [6-(trifluoromethyl)pyridin-2-yl]methanol 
• 108337-80-0 2,6-dimethyl-4-(6-trifluoromethyl-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester 
• 781637-62-5 2-(bromomethyl)-6-(trifluoromethyl)pyridine 
• 1321515-80-3 6-[2-methyl-6-(trifluoromethyl)pyridin-4-yl]-5-phenyl-1,2,4-triazin-3-amine 

Relevant articles and documents

CRYSTAL FORM AND SALT TYPE OF TRIAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREOF

Disclosed in the present invention are a crystal form of a [1,2,4]triazolo[1,5-c]pyrimidine compound and a preparation method thereof. Further disclosed is a use of the crystal form in the preparation of a medicament for treating A2A receptor r

NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS II

The invention relates novel NK1 receptor antagonists represented in formula A, wherein R1 and R2 independently are selected from the group consisting of (C1-4)alkyl, (C1-4)haloalkyl, (C1-4)alkoxy, CD

Trifluoromethylation of aryl and heteroaryl halides with fluoroform-derived CuCF3: Scope, limitations, and mechanistic features

Fluoroform-derived CuCF3 recently discovered in our group exhibits remarkably high reactivity toward aryl and heteroaryl halides, performing best in the absence of extra ligands. A broad variety of iodoarenes undergo smooth trifluoromethylation with the ligandless CuCF3 at 23-50 C to give the corresponding benzotrifluorides in nearly quantitative yield. A number of much less reactive aromatic bromides also have been trifluoromethylated, including pyridine, pyrimidine, pyrazine, and thiazole derivatives as well as aryl bromides bearing electron-withdrawing groups and/or ortho substituents. Only the most electrophilic chloroarenes can be trifluoromethylated, e.g., 2-chloronicotinic acid. Exceptionally high chemoselectivity of the reactions (no side-formation of arenes, biaryls, and C2F5 derivatives) has allowed for the isolation of a large number of trifluoromethylated products in high yield on a gram scale (up to 20 mmol). The CuCF3 reagent is destabilized by CuX coproduced in the reaction, the magnitude of the effect paralleling the Lewis acidity of CuX: CuCl > CuBr > CuI. While SNAr and SRN1 mechanisms are not operational, there is a well-pronounced ortho effect, i.e., the enhanced reactivity of ortho-substituted aryl halides 2-RC6H4X toward CuCF3. Intriguingly, this ortho-effect is observed for R = NO2, COOH, CHO, COOEt, COCH3, OCH3, and even CH3, but not for R = CN. The fluoroform-derived CuCF3 reagent and its reactions with haloarenes provide an unmatched combination of reactivity, selectivity, and low cost.