- Dynamic Kinetic Resolution of Alcohols by Enantioselective Silylation Enabled by Two Orthogonal Transition-Metal Catalysts
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A nonenzymatic dynamic kinetic resolution of acyclic and cyclic benzylic alcohols is reported. The approach merges rapid transition-metal-catalyzed alcohol racemization and enantioselective Cu-H-catalyzed dehydrogenative Si-O coupling of alcohols and hydrosilanes. The catalytic processes are orthogonal, and the racemization catalyst does not promote any background reactions such as the racemization of the silyl ether and its unselective formation. Often-used ruthenium half-sandwich complexes are not suitable but a bifunctional ruthenium pincer complex perfectly fulfills this purpose. By this, enantioselective silylation of racemic alcohol mixtures is achieved in high yields and with good levels of enantioselection.
- Oestreich, Martin,Seliger, Jan
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supporting information
p. 247 - 251
(2020/10/29)
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- TRANSITION METAL ISONITRILE CATALYSTS
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The present disclosure relates to new transition metal isonitrile compounds, processes for the production of the compounds and the use of the compounds as catalysts. The disclosure also relates to the use of the metal isonitrile compounds as catalysts for hydrogenation and transfer hydrogenation of compounds containing one or more carbon-oxygen, and/or carbon-nitrogen and/or carbon-carbon double bonds.
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Page/Page column 21; 22
(2018/11/22)
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- A molecular iron catalyst for the acceptorless dehydrogenation and hydrogenation of N-heterocycles
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A well-defined iron complex (3) supported by a bis(phosphino)amine pincer ligand efficiently catalyzes both acceptorless dehydrogenation and hydrogenation of N-heterocycles. The products from these reactions are isolated in good yields. Complex 3, the active catalytic species in the dehydrogenation reaction, is independently synthesized and characterized, and its structure is confirmed by X-ray crystallography. A trans-dihydride intermediate (4) is proposed to be involved in the hydrogenation reaction, and its existence is verified by NMR and trapping experiments.
- Chakraborty, Sumit,Brennessel, William W.,Jones, William D.
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supporting information
p. 8564 - 8567
(2014/07/07)
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- PNP pincer osmium polyhydrides for catalytic dehydrogenation of primary alcohols
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This paper reports the synthesis, structure, and properties of a series of PNP pincer complexes of osmium OsH3Cl[HN(C2H 4PiPr2)2] (1), OsH 3[N(C2H4PiPr2) 2] (2), OsH4[HN(C2H4P iPr2)2] (3), and OsH2(PMe 3)[HN(C2H4PiPr2) 2] (4). The tetrahydride 3 operates as an efficient catalyst at 0.1 mol% loading for the reactions of amination and dehydrogenative coupling of primary alcohols, producing secondary amines and symmetrical esters, respectively. The catalyst 3 is distinguished by outstanding stability, and it can be used in an aqueous environment at temperatures as high as 200 °C. The Royal Society of Chemistry 2011.
- Bertoli, Marcello,Choualeb, Aldjia,Gusev, Dmitry G.,Lough, Alan J.,Major, Quinn,Moore, Brandon
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experimental part
p. 8941 - 8949
(2011/10/12)
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- IRIDIUM CATALYSTS FOR CATALYTIC HYDROGENATION
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The present disclosure relates to a process for the reduction of compounds comprising one or more carbon-oxygen (C═O) double bonds, to provide the corresponding alcohol, comprising contacting the compound with hydrogen gas at a pressure greater than 3 atm and a catalyst comprising an iridium aminodiphosphine complex.
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Page/Page column 5
(2009/01/20)
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- TRANSFER HYDROGENATION PROCESSES AND CATALYSTS
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The invention relates to a process for the reduction of compounds comprising a carbon-carbon (C=C), carbon-oxygen (C=O), or carbon-nitrogen (C=N) double bond, to a corresponding hydrogenated alkane, alcohol or amine, comprising contacting a compound comprising the C=C, C=O or C=N double bond with a hydrogen donor solvent and a catalyst comprising a metal complex having a tridentate aminodiphosphine ligand under transfer hydrogenation conditions.
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