82475-57-8 Usage
Uses
Used in Oncology:
N,N-bis(2-chloroethyl)-1,1,1-trimethylsilanamine is used as an anti-cancer agent for the treatment of various malignancies. Its alkylating mechanism targets the DNA of cancer cells, preventing them from dividing and leading to their destruction. This makes it a valuable component in cancer therapy, despite its highly toxic nature which necessitates careful handling and patient monitoring to manage potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 82475-57-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,4,7 and 5 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 82475-57:
(7*8)+(6*2)+(5*4)+(4*7)+(3*5)+(2*5)+(1*7)=148
148 % 10 = 8
So 82475-57-8 is a valid CAS Registry Number.
82475-57-8Relevant academic research and scientific papers
Synthesis, hydrolytic reactivity, and anticancer evaluation of N-and O-triorganosilylated compounds as new types of potential prodrugs
Chiu,Chang,Ozkan,Zon,Fichter,Phillips
, p. 542 - 551 (2007/10/02)
N- and O-Triorganosilylated compounds related to various anticancer agents were synthesized for evaluation as potential anticancer prodrugs. 1H-NMR and UV kinetic measurements of hydrolytic desilylation were used to correlate relative rates of structural unmasking with steric bulk about the silicon reaction center. The tert-butyldimethylsilyl ester of chlorambucil and a number of O-triorganosilylated carbamate derivatives of nor-nitrogen mustard showed significant activity against P-388 lymphocytic leukemia in mice.
