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(2E)-1-(4-bromophenyl)-3-(furan-2-yl)prop-2-en-1-one, also known as chalcone, is an organic compound that features a substituted phenyl ring and a furan ring connected by a propenone linker. This yellow solid is widely recognized for its applications in organic synthesis and medicinal chemistry, as well as for its diverse biological activities such as antitumor, anti-inflammatory, and antioxidant properties. Chalcone also serves as a precursor in the synthesis of various natural and synthetic compounds, making it a valuable asset in pharmaceutical research and drug development.

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  • 132434-53-8 Structure
  • Basic information

    1. Product Name: (2E)-1-(4-bromophenyl)-3-(furan-2-yl)prop-2-en-1-one
    2. Synonyms: (2E)-1-(4-bromophenyl)-3-(furan-2-yl)prop-2-en-1-one
    3. CAS NO:132434-53-8
    4. Molecular Formula: C13H9BrO2
    5. Molecular Weight: 277.11336
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 132434-53-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 376.3°C at 760 mmHg
    3. Flash Point: 181.4°C
    4. Appearance: /
    5. Density: 1.467g/cm3
    6. Vapor Pressure: 7.31E-06mmHg at 25°C
    7. Refractive Index: 1.629
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: (2E)-1-(4-bromophenyl)-3-(furan-2-yl)prop-2-en-1-one(CAS DataBase Reference)
    11. NIST Chemistry Reference: (2E)-1-(4-bromophenyl)-3-(furan-2-yl)prop-2-en-1-one(132434-53-8)
    12. EPA Substance Registry System: (2E)-1-(4-bromophenyl)-3-(furan-2-yl)prop-2-en-1-one(132434-53-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 132434-53-8(Hazardous Substances Data)

132434-53-8 Usage

Uses

Used in Pharmaceutical Research and Drug Development:
(2E)-1-(4-bromophenyl)-3-(furan-2-yl)prop-2-en-1-one is used as a chemical intermediate for the synthesis of a variety of natural and synthetic compounds, contributing to the advancement of pharmaceutical research and drug development.
Used in Organic Synthesis:
In the field of organic synthesis, (2E)-1-(4-bromophenyl)-3-(furan-2-yl)prop-2-en-1-one is utilized as a key building block, facilitating the creation of complex organic molecules and contributing to the development of new chemical entities.
Used in Medicinal Chemistry:
(2E)-1-(4-bromophenyl)-3-(furan-2-yl)prop-2-en-1-one is employed as a lead compound in medicinal chemistry, where its biological activities, such as antitumor, anti-inflammatory, and antioxidant properties, are harnessed for the development of potential therapeutic agents.
Used in Antitumor Applications:
In oncology, (2E)-1-(4-bromophenyl)-3-(furan-2-yl)prop-2-en-1-one is used as an antitumor agent, leveraging its biological activities to target and combat cancer cells, potentially leading to the development of novel cancer treatments.
Used in Anti-inflammatory Applications:
(2E)-1-(4-bromophenyl)-3-(furan-2-yl)prop-2-en-1-one is utilized as an anti-inflammatory agent, where its properties can be applied to alleviate inflammation and associated conditions, contributing to the development of new anti-inflammatory medications.
Used in Antioxidant Applications:
As an antioxidant, (2E)-1-(4-bromophenyl)-3-(furan-2-yl)prop-2-en-1-one is used to combat oxidative stress and related conditions, playing a role in the development of antioxidants that can protect cells from damage and promote overall health.

Check Digit Verification of cas no

The CAS Registry Mumber 132434-53-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,4,3 and 4 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 132434-53:
(8*1)+(7*3)+(6*2)+(5*4)+(4*3)+(3*4)+(2*5)+(1*3)=98
98 % 10 = 8
So 132434-53-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H9BrO2/c14-11-5-3-10(4-6-11)13(15)8-7-12-2-1-9-16-12/h1-9H/b8-7+

132434-53-8Relevant articles and documents

Novel 4,5-dihydro-1H-pyrazole derivatives as potential succinate dehydrogenase inhibitors: design, synthesis, crystal structure, biological activity and molecular modeling

Cheng, Wei,Jiang, Wenjing,Liu, Hui,Lu, Tong,Tang, Xiaorong,Wang, Jingwen,Xiao, Tingting,Zhang, Guilan,Zhang, Tingting

, (2021/10/05)

Twenty-eight new 4, 5-dihydro-1H-pyrazole derivatives were designed, synthesized and characterized by IR, 1H NMR, 13C NMR and HRMS. The crystal structure of compound 2j was characterized by single crystal X-ray diffraction. Their ant

Design, synthesis, and antifungal activity evaluation of novel 2-cyano-5-oxopentanoic acid derivatives as potential succinate dehydrogenase inhibitors

Mai, Yong-zhan,Peng, Mi-jun,Tang, Xiao-rong,Wang, Xue-song

, p. 94 - 107 (2021/11/22)

Two series of novel 2-cyano-5-oxopentanoic acid derivatives (1a?l, 2a?l) were designed, synthesized, and characterized by IR, 1H NMR, 13C NMR, and HRMS. Their in vitro antifungal activity against five plant pathogenic fungi were then

Design, synthesis and insecticidal activity of novel semicarbazones and thiosemicarbazones derived from chalcone

Cheng, Wei,Xiao, Tingting,Qian, Weifeng,Lu, Tong,Zhang, Tingting,Tang, Xiaorong

, p. 3801 - 3809 (2020/03/23)

Thirty semicarbazone and thiosemicarbazone derivatives (2a–w and 4a–g) from chalcones containing furan and thiophene ring were designed and synthesized. They were characterized by IR, 1H NMR, 13C NMR and HRMS. The crystal structure o

6-methoxypyridine derivative and application thereof in pesticide

-

Paragraph 0060-0062, (2021/06/22)

The invention relates to a 6-methoxypyridine derivative and application thereof in pesticides, which belong to the technical field of pesticides. The structural formula of the 6-methoxyl pyridine derivative is shown as a formula (I), and in the formula (I

Transition metal-free domino aryl-aryl coupling/phospha-Michael addition of diarylphosphinite to α,β-unsaturated ketones triggered by alkaline hydrolysis of (4-(2-alkenoyl)phenyl)triarylphosphonium salts

Huang, Wenhua,Xue, Jing-Yu

, (2021/11/08)

Alkaline hydrolysis of a variety of (4-(2-alkenoyl)phenyl)triarylphosphonium bromides is reported. This hydrolysis triggers coupling of 4-(2-alkenoyl)phenyl with one aryl via phosphorus(V). Both diarylphosphinite and an α,β-unsaturated ketone are in situ generated and then undergo phospha-Michael addition to provide β-diarylphosphoryl ketones bearing a biaryl moiety in 27–70% yields in the absence of a transition metal.

4, 5-dihydropyrazole compound and application thereof in pesticides

-

Paragraph 0055-0057, (2020/05/14)

The invention relates to a 4, 5-dihydropyrazole compound and an application thereof in pesticides, which belong to the technical field of pesticides. The technical problem to be solved by the invention is to provide a new compound which can be used as an

Studies of NMR Chemical Shifts of Chalcone Derivatives of Five-membered Monoheterocycles and Determination of Aromaticity Indices

Jeong, Eun Jeong,Lee, In-Sook Han

, p. 668 - 673 (2019/07/12)

A series of the chalcone derivatives of the five-membered monoheterocyclic compounds, (E)-1-aryl-3-heteroarylpropen-1-ones, were prepared by aldol condensation of the corresponding aldehydes of thiophene, pyrrole, and furan with m- and p-substituted acetophenones. Similar condensation of the acetyl compounds of the heterocycles with m- and p-substituted benzaldehydes gave another series of the chalcone derivatives, (E)-1-heteroaryl-3-arylpropen-1-ones. The 13C chemical shift values (δC) of the chalcone derivatives were determined in order to find if they correlated with the Hammett σ values. A good correlation, especially for the β-C for both series, was found for the 13C chemical shift values (δC) of the chalcone derivatives with the Hammett σ values. The chemical shift values of the β-C of the heterocyclic compounds were plotted against those of the benzene derivatives. The resulting slopes were found to be close to the values of the aromaticity indices.

1-(2-furyl)-3-(4-substituted phenyl)propylene derivative as well as preparation method and application thereof

-

Paragraph 0047; 0048, (2016/10/07)

The invention provides a 1-(2-furyl)-3-(4-substituted phenyl)propylene derivative as well as a preparation method and application thereof. The derivative has a structural formula (I) shown in the following description; in the structural formula (I), R is

3-(2-furyl)propenol derivative as well as preparation method and application thereof

-

Paragraph 0046; 0047, (2016/10/09)

The invention provides a 3-(2-furyl)propenol derivative as well as a preparation method and application thereof. The derivative has a structural formula (I) shown in the following description; in the structural formula (I), R is a fluorine atom, a chlorin

Semicarbazone compound and preparation method and application thereof

-

Paragraph 0047; 0048, (2016/10/31)

The invention provides a semicarbazone compound and a preparation method and application thereof. The structural general formula of the compound is shown in the description, wherein the R represents fluorine atoms, chlorine atoms, bromine atoms, iodine at

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