132464-87-0Relevant articles and documents
COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS
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Page/Page column 201, (2009/10/22)
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is -CR4=CR5.
Thienotriazolodiazepines as platelet-activating factor antagonists. Steric limitations for the substituent in position 2
Walser,Flynn,Mason,Crowley,Maresca,O'Donnell
, p. 1440 - 1446 (2007/10/02)
The preparations of thienotriazolodiazepines bearing a substituted ethynyl group at the 2-position, and the corresponding cis-olefins and fully saturated analogues are described. The compounds were evaluated as potential antagonists of platelet-activating