133627-17-5 Usage
Uses
Used in Pharmaceutical Industry:
5,11-dihydro-6H-11-ethyl-4-Methyl-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one is used as a pharmaceutical compound for its potential therapeutic effects. It may be employed in the development of new drugs targeting specific diseases or conditions, due to its ability to interact with biological targets and modulate cellular processes.
Used in Chemical Research:
In the field of chemical research, 5,11-dihydro-6H-11-ethyl-4-Methyl-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one serves as a valuable compound for studying its chemical properties, reactivity, and potential applications in various chemical reactions. Researchers can use this molecule to explore new synthetic pathways, develop novel chemical methods, and gain insights into its structure-activity relationships.
Used as an Impurity in Nevirapine Production:
5,11-dihydro-6H-11-ethyl-4-Methyl-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one is an impurity found in the production of Nevirapine (N391275), an antiretroviral medication used to treat HIV-1 infection. The presence of this compound in the manufacturing process may affect the quality, efficacy, or safety of the final product. Therefore, it is essential to monitor and control the levels of this impurity during the production of Nevirapine to ensure the desired pharmaceutical quality.
Check Digit Verification of cas no
The CAS Registry Mumber 133627-17-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,6,2 and 7 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 133627-17:
(8*1)+(7*3)+(6*3)+(5*6)+(4*2)+(3*7)+(2*1)+(1*7)=115
115 % 10 = 5
So 133627-17-5 is a valid CAS Registry Number.
133627-17-5Relevant articles and documents
5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
-
, (2008/06/13)
Disclosed are novel 5,11-dihydro-6H-dipyrido[3,2-b; 2',3'-e][1,4]diazepines. These are useful in the prevention or treatment of HIV infection.
Novel Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 1. Tricyclic Pyridobenzo- and Dipyridodiazepinones
Hargrave, Karl D.,Proudfoot, John R.,Grozinger, Karl G.,Cullen, Ernest,Kapadia, Suresh R.,et al.
, p. 2231 - 2241 (2007/10/02)
Novel pyridobenzodiazepinones (I), pyridobenzodiazepinones (II), and dipyridodiazepinones (III) were found to inhibit human immunodeficiency virus type 1 (HIV-1) reverse transcriptase in vitro at concentrations as low as 35 nM.In all three series, small substituents (e.g., methyl, ethyl, acetyl) are preferred at the lactam nitrogen, whereas slightly larger alkyl moieties (e.g., ethyl, cyclopropyl) are favored at the other (N-11) diazepinone nitrogen.In general, lipophilic substituents are preferred on the A ring, whereassubstitution on the C ring generally reduces potency relative to the corresponding compounds with no substituents on the aromatic rings.Maximum potency is achieved with methyl substitution at the position ortho to the lactam nitrogen atom; however, in this case an unsubstituted lactam nitrogen is preferred.Additional substituents on the A ring can be readily tolerated.The dipyridodiazepinone derivative 11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyridodiazepin-6-one (96, nevirapine) is a potent (IC50 = 84 nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase, and has been chosen for clinical evaluation.
