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  • 13367-81-2 Structure
  • Basic information

    1. Product Name: N-methylacridine
    2. Synonyms: N-methylacridine;10-METHYLACRIDINE
    3. CAS NO:13367-81-2
    4. Molecular Formula: C14H12N
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 13367-81-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: °Cat760mmHg
    3. Flash Point: °C
    4. Appearance: /
    5. Density: g/cm3
    6. Vapor Pressure: 8.8E-06mmHg at 25°C
    7. Refractive Index: 1.662
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: N-methylacridine(CAS DataBase Reference)
    11. NIST Chemistry Reference: N-methylacridine(13367-81-2)
    12. EPA Substance Registry System: N-methylacridine(13367-81-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 13367-81-2(Hazardous Substances Data)

13367-81-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 13367-81-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,3,6 and 7 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 13367-81:
(7*1)+(6*3)+(5*3)+(4*6)+(3*7)+(2*8)+(1*1)=102
102 % 10 = 2
So 13367-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H13N/c1-15-13-8-4-2-6-11(13)10-12-7-3-5-9-14(12)15/h2-6,8-10H,7H2,1H3

13367-81-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 10-methylacridin-10-ium

1.2 Other means of identification

Product number -
Other names 10-methylacridinium ion

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13367-81-2 SDS

13367-81-2Relevant articles and documents

Outer-Sphere Electron-Transfer Oxidation of 10,10'-Dimethyl-9,9',10,10'-tetrahydro-9,9-biacridine

Fukuzumi, Shunichi,Tokuda, Yoshihiro

, p. 8409 - 8413 (1992)

10,10'-Dimethyl-9,9',10,10'-tetrahydro-9,9'-biacridine acts as a unique two-electron donor in the electron-transfer oxidation with various organic oxidants.The rate-determining step is electron transfer from (AcrH)2 to oxidants, followed by facile cleavage of the C(9)-C bond of (AcrH)2.+ to yield the acridinyl radical (AcrH.) and 10-methylacridinium ion (AcrH+).The second electron transfer from AcrH. to oxidants is much faster than the initial electron transfer from (AcrH)2 to oxidants.On the other hand, the corresponding monomer, 10-methyl-9,10-dihydroacridine (AcrH2), acts as a normal hydride (two electrons and proton) donor in the reactions with oxidants.Rates of electron-transfer reactions from (AcrH)2 to various inorganic and organic one-electron oxidants depend solely on the one-electron-reduction potentials of the oxidants irrespective of the size of the oxidants, indicating that (AcrH)2 acts as a novel two-electron outer-sphere electron-transfer reagent.The one-electron-oxidation potential of (AcrH)2 (vs SCE) has been evaluated as 0.62 V, which is less positive than that of the corresponding monomer (0.80 V).

Double fragmentation in cation radicals. An example in the NADH analogues series

Anne, Agnes,Fraoua, Sylvie,Moiroux, Jacques,Saveant, Jean-Michel

, p. 774 - 780 (1998)

The cation radical of 9-tert-butyl-N-methylacridan, generated electrochemically or photochemically, offers, in the presence of strong bases, a remarkable example of a double fragmentation. Whereas in acidic or weakly basic media the tert-butyl radical is cleaved with concomitant formation of the methylacridinium cation, the presence of a strong base triggers the cleavage of both the methyl group borne by the nitrogen atom and the tert-butyl group on C-9 leading to acridine, formaldehyde and the tert-butyl anion, even though methylacridinium cation is stable under these conditions. The origin of this unprecedented behavior resides in the prior deprotonation of the methyl group borne by the nitrogen atom which outruns the usual deprotonation at the 9-carbon because this is slowed by the steric hindrance due to the presence of the tert-butyl group.

Acid Catalysed Reduction of Aromatic Aldehydes by an NADH Model Compound

Fukuzumi, Shunichi,Ishikawa, Masashi,Tanaka, Toshio

, p. 1069 - 1071 (1985)

The electronic substituent effects on the rates of acid catalysed reduction of aromatic aldehydes by an acid-stable NADH model compound (N-methylacridan) are shown to be very small, compatible with those observed for liver alcohol dehydrogenase catalysed reduction of aromatic aldehydes by NADH.

Photoinduced Cleavage of the C-C Bond of 9-(1-Naphthylmethyl)-10-methyl-9,10-dihydroacridine by Perchloric Acid via Intramolecular Electron-Transfer Excitation

Fukuzumi, Shunichi,Tokuda, Yoshihiro,Fujita, Morifumi

, p. 8413 - 8416 (1992)

The C(9)-C bond of 9-(1-naphthylmethyl)-10-methyl-9,10-dihydroacridine (AcrHR) is readily cleaved by HClO4 in acetonitrile (MeCN) under irradiation of the absorption band of AcrHR to yield RH and AcrH+.The dependence of the fluorescence maximum on solvent dielectric constant indicates a highly polar singlet excited state with the dipole moment of ca. 15.6 D, while the fluorescence maximum of 9,10-dihydro-10-methylacridine (AcrH2) is insensitive to the solvent.The fluorescence of AcrHR is efficiently quenched by HClO4 with the rate constant of 8.6 * 109 M-1 s-1 in MeCN at 298 K.The same quenching rate constant has been obtained from the dependence of the quantum yields on for the photoinduced cleavage of the C-C bond of AcrHR by HClO4 in MeCN at 298 K.Thus, the photoinduced intramolecular charge transfer from the acridine moiety to the naphthalene moiety in AcrHR results in the generation of the highly polarized C-C bond which is susceptible to the cleavage by HClO4.The C(9)-C bond of AcrHR is also cleaved upon the intermolecular electron-transferoxidation of AcrHR by Fe(ClO4)3 and Fe(phen)3 and Fe(phen)33+ (phen = 1,10-phenanthroline) in MeCN to yield AcrH+, while the C(9)-H bond is cleaved in the case of AcrH2.

Hydride-exchange reactions between NADH and NAD+ model compounds under non-steady-state conditions. Apparent and real kinetic isotope effects

Lu, Yun,Zhao, Yixing,Handoo, Kishan L.,Parker, Vernon D.

, p. 173 - 181 (2003)

The kinetics of the hydride exchange reaction between NADH model compound 10-methyl-9,10-dihydroacridine (MAH) and 1-benzyl-3-cyanoquinolinium (BQCN+) ion in acetonitrile were studied at temperatures ranging from 291 to 325 K. The extent of reaction-time profiles during the first half-lives are compared with theoretical data for the simple single-step mechanism and a 2-step mechanism involving initial donor/acceptor complex formation followed by unimolecular hydride transfer. The profiles for the reactions of MAH deviate significantly from those expected for the simple single-step mechanism with the deviation increasing with increasing temperature. The deviation from simple mechanism behavior is much less pronounced for the reactions of 10-methyl-9,10-dihydro-acridine-10,10-d2 (MAD) which gives rise to extent of reaction dependent apparent kinetic isotope effects (KIEapp). Excellent fits of the experimental extent of reaction-time profiles with theoretical data for the 2-step mechanism, in the pre-steady-state time period, were observed in all cases. Resolution of the kinetics of the hydride exchange reaction into the microscopic rate constants over the entire temperature range resulted in real kinetic isotopes effects for the hydride transfer step ranging from 40 (291 K) to 8.2 (325 K). That the reaction involves significant hydride tunnelling was verified by the magnitudes of the Arrihenius parameters: EaD - EaH = 8.7 kcal mol-1 and AD/AH = 8 × 104. An electron donor acceptor complex (λmax = 526 nm) was observed to be a reaction intermediate. Theoretical extent of reaction-time profile data are discussed for the case where a reaction intermediate is formed in a non-productive side equilibrium as compared to the case where it is a real intermediate on the reaction coordinate between reactants and products. The common assumption that the two cases are kinetically indistinguishable is shown to be incorrect.

A classical but new kinetic equation for hydride transfer reactions

Zhu, Xiao-Qing,Deng, Fei-Huang,Yang, Jin-Dong,Li, Xiu-Tao,Chen, Qiang,Lei, Nan-Ping,Meng, Fan-Kun,Zhao, Xiao-Peng,Han, Su-Hui,Hao, Er-Jun,Mu, Yuan-Yuan

, p. 6071 - 6089 (2013/09/12)

A classical but new kinetic equation to estimate activation energies of various hydride transfer reactions was developed according to transition state theory using the Morse-type free energy curves of hydride donors to release a hydride anion and hydride acceptors to capture a hydride anion and by which the activation energies of 187 typical hydride self-exchange reactions and more than thirty thousand hydride cross transfer reactions in acetonitrile were safely estimated in this work. Since the development of the kinetic equation is only on the basis of the related chemical bond changes of the hydride transfer reactants, the kinetic equation should be also suitable for proton transfer reactions, hydrogen atom transfer reactions and all the other chemical reactions involved with breaking and formation of chemical bonds. One of the most important contributions of this work is to have achieved the perfect unity of the kinetic equation and thermodynamic equation for hydride transfer reactions. The Royal Society of Chemistry.

A mechanistic dichotomy in scandium ion-promoted hydride transfer of an NADH analogue: Delicate balance between one-step hydride-transfer and electron-transfer pathways

Yuasa, Junpei,Yamada, Shunsuke,Fukuzumi, Shunichi

, p. 14938 - 14948 (2008/02/03)

The rate constant (kH) of hydride transfer from an NADH analogue, 9,10-dihydro-10-methylacridine (AcrH2), to 1-(p-tolylsulfinyl)-2,5-benzoquinone (TolSQ) increases with increasing Sc 3+ concentration ([Sc3+]) to reach a constant value, when all TolSQ molecules form the TolSQ-Sc3+ complex. When AcrH 2 is replaced by the dideuterated compound (AcrD2), however, the rate constant (kD) increases linearly with an increase in [Sc3+] without exhibiting a saturation behavior. In such a case, the primary kinetic deuterium isotope effect (kH/kD) decreases with increasing [Sc3+]. On the other hand, the rate constant of Sc3+-promoted electron transfer from tris(2- phenylpyridine)iridium [Ir(ppy)3] to TolSQ also increases linearly with increasing [Sc3+] at high concentrations of Sc3+ due to formation of a 1:2 complex between TolSQ?- and Sc 3+, [TolSQ?- (Sc3+)2], which was detected by ESR. The significant difference with regard to dependence of the rate constant of hydride transfer on [Sc3+] between AcrH2 and AcrD2 in comparison with that of Sc3+-promoted electron transfer indicates that the reaction pathway is changed from one-step hydride transfer from AcrH2 to the TolSQ-Sc3+ complex to Sc3+-promoted electron transfer from AcrD2 to the TolSQ-Sc3+ complex, followed by proton and electron transfer. Such a change between two reaction pathways, which are employed simultaneously, is also observed by simple changes of temperature and concentration of Sc3+.

Comparison between electron transfer and nucleophilic reactivities of ketene silyl acetals with cationic electrophiles

Fukuzumi,Ohkubo,Otera

, p. 1450 - 1454 (2007/10/03)

The products and kinetics for the reactions of ketone silyl acetals with a series of p-methoxy-substituted trityl cations have been examined, and they are compared with those of outer-sphere electron transfer reactions from 10,10′-dimethyl-9,9′, 10, 10′- tetrahydro-9,9′-biacridine [(AcrH)2] to the same series of trityl cations as well as other electron acceptors. The C-C bond formation in the reaction of β,β-dimethyl-substituted ketene silyl acetal (1: (Me2C=C(OMe)OSiMe3) with trityl cation salt (Ph3C+ClO4-) takes place between 1 and the carbon of para-positon of phenyl group of Ph3C+, whereas a much less sterically hindered ketene silyl acetal (3: H2C=C(OEt)OSiEt3) reacts with Ph3C+ at the central carbon of Ph3C+. The kinetic comparison indicates that the nucleophilic reactivities of ketene silyl acetals are well correlated with the electron transfer reactivities provided that the steric demand at the reaction center for the C-C bond formation remains constant.

Oxidation mechanism of NAD dimer model compounds

Patz, Matthias,Kuwahara, Yoshihiro,Suenobu, Tomoyoshi,Fukuzumi, Shunichi

, p. 567 - 568 (2007/10/03)

The oxidation of a dimeric N-benzyldihydronicotinamide with various oxidants such as quinones, triphenyl carbenium ions and a triplet exited tris(bipyridine) ruthenium(II) complex occurs via initial outer-sphere electron transfer followed by fast C-C bond cleavage and second electron transfer. The kinetic studies allow the determination of the oxidation potential of this compound.

Acid-Catalyzed Photoreduction of Dialkyl Sulfoxides by an Acid-Stable NADH Analogue

Fukuzumi, Shunichi,Tokuda, Yoshihiro

, p. 897 - 900 (2007/10/02)

Photoreduction of dialkyl sulfoxides by an acid-stable NADH analogue, 9,10-dihydro-10-methylacridine (AcrH2), proceeds in the presence of perchloric acid in acetonitrile via photoinduced electron transfer from the singlet excited state of AcrH2 to protonated sulfoxides to yield the corresponding dialkyl sulfides.

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