134575-07-8

Basic information

• Product Name: exo-3-Benzyl-3-azabicyclo[3.1.0]hexane-6-methanol
• Synonyms: exo-3-Benzyl-3-azabicyclo[3.1.0]hexane-6-methanol;exo-3-Benzyl-3-azabicyclo...;(1R,5S,6R)-3-Aza-3-benzyl-6-(hydroxymethyl)bicyclo[3.1.0]hexane 95+%;[(1R,5S,6R)-3-Aza-3-benzylbicyclo[3.1.0]hex-6-yl]methanol;[(1S,5R)-3-Benzyl-3-azabicyclo[3.1.0]hexan-6-yl]Methanol;(1R,5S,6R)-3-Aza-3-benzyl-6-(hydroxymethyl)bicyclo[3.1.0]hexane;-3-Benzyl-3-azabicyclo[3.1.0]hexan-6-yl);EOS-61752
• CAS NO: 134575-07-8
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.28018
• Mol File: 134575-07-8.mol

Chemical Properties

• Boiling Point: 312.3±15.0 °C(Predicted)
• Appearance: /
• Density: 1.158±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.94±0.10(Predicted)
• CAS DataBase Reference: exo-3-Benzyl-3-azabicyclo[3.1.0]hexane-6-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: exo-3-Benzyl-3-azabicyclo[3.1.0]hexane-6-methanol(134575-07-8)
• EPA Substance Registry System: exo-3-Benzyl-3-azabicyclo[3.1.0]hexane-6-methanol(134575-07-8)

Safety Data

• Hazardous Substances Data: 134575-07-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Exo-3-Benzyl-3-azabicyclo[3.1.0]hexane-6-methanol serves as a valuable building block in the synthesis of a variety of pharmaceutical compounds. Its unique molecular structure allows it to be a key component in creating complex organic molecules for various applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, exo-3-Benzyl-3-azabicyclo[3.1.0]hexane-6-methanol is utilized as a starting material for the development of new drug candidates. Its structural features and properties make it a promising candidate for the creation of therapeutic agents with potential health benefits.
Used in Pharmaceutical Industry:
Exo-3-Benzyl-3-azabicyclo[3.1.0]hexane-6-methanol is used as a precursor in the pharmaceutical industry for the development of innovative drugs. Its potential applications in this industry are vast, given its ability to contribute to the synthesis of compounds with therapeutic properties.
The specific properties and potential applications of exo-3-Benzyl-3-azabicyclo[3.1.0]hexane-6-methanol necessitate further research and exploration in the field of organic chemistry to fully harness its capabilities and benefits.

Upstream product

• 146726-13-8 3-benzyl-3-azabicyclo[3.1.0]hexane-2,4-dione-6-carboxylic acid ethyl ester 
• 187681-87-4 (1R,5S,6s)-2,4-dioxo-3-oxabicyclo[3.1.0]hexane-6-carboxylic acid 
• 1366657-90-0 (1R,5S,6r)-3-benzyl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylic acid 
• 134575-05-6 ethyl 5-benzyl-4,6-dioxo-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrazole-3-carboxylate 
• 705-35-1 trans,meso-1,2,3-cyclopropanetricarboxylic acid 
• 13949-99-0 trans,meso-cyclopropanetricarboxylic acid triethyl ester 
• 1631-26-1 1-benzyl-1H-pyrrole-2,5-dione 
• 134575-06-7 ethyl (1α,5α,6α)-3-benzyl-3-azabicyclo[3.1.0]hexane-2,4-dione-6-carboxylate 

Downstream Products

• 134575-13-6 (1α,5α,6α)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane 
• 134575-08-9 [1α,5α,6α]-3-Benzyl-3-azabicyclo[3.1.0]hexane-6-carboxaldehyde 
• 134575-17-0 tert-butyl (1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylcarbamate 
• 134575-10-3 [1α,5α,6α]-6-Aminomethyl-3-benzyl-3-azabicyclo[3.1.0]hexane 
• 134575-12-5 (1α,5α,6α)-6-(tert-butoxycarbonyl)aminomethylene-3-azabicyclo[3.1.0]hexane 
• 134575-14-7 benzyl (1α,5α,6α)-6-hydroxymethyl-3-azabicyclo[3.1.0]hexan-3-ylcarboxylate 
• 134575-15-8 (1α,5α,6α)-3-(benzyloxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid 
• 134575-11-4 ((1R,5S,6S)-3-Benzyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-carbamic acid tert-butyl ester 
• 146726-08-1 (1α,5α,6α)-6-tert-butoxycarbonylamino-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid benzyl ester 
• 925457-08-5 1-(2,4-difluorophenyl)-7-[(1α,5α,6α)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid 
• 925457-09-6 1-(2,4-difluorophenyl)-7-[(1α,5α,6α)-6-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-3-azabicyclo[3.1.0]hex-3-yl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid 
• 1366664-25-6 [(1R,5S,6r)-3-benzyl-3-azabicyclo[3.1.0]hex-6-yl]methyl methanesulfonate 
• 1173177-20-2 C₁₈H₂₄ClFN₂O₂ 
• 1173177-23-5 C₂₃H₂₈ClFN₄O₃ 

Relevant articles and documents

Synthesis of new fluoroquinolones and evaluation of their in vitro activity on Toxoplasma gondii and Plasmodium spp.

The synthesis of four new computer-designed fluoroquinolones which have been predicted by QSAR analysis to be active against the protozoa Toxoplasma gondii is described. These compounds are inhibitory in vitro for T. gondii. One of these compounds has a remarkably high activity comparable to that of trovafloxacin. It combines the basic cyclopropyl-quinoline structure of gatifloxacin or moxifloxacin with the C-7 6-amino-3-azabicyclo[3.1.0]hexyl side chain of trovafloxacin. The four compounds are also inhibitory for blood stages of Plasmodium falciparum though at high concentration. These results confirm the potential of quinolones as anti-T. gondii and antimalarial drugs but also show that the QSAR models for T. gondii cannot be reliably extended for screening antimalarial activity.

Azabicyclo quinolone carboxylic acids

Quinolone carboxylic acids 7-substituted by azabicyclo groups have antibacterial activity., Antibacterial wherein, R1 is hydrogen, a pharmaceutically acceptable cation, or alkyl;, Y, when taken independently, is ethyl, t-butyl, vinyl, cyclopropyl, 2-fluoroethyl, p-fluorophenyl, or o,p-difluorophenyl;, W is hydrogen, F, Cl, Br, alkyl, alkoxy, NH2, NHCH3;, A is CH, CF, CCl, COCH3, C-CH3, C-CN or N; or, A is carbon and is taken together with Y and the carbon and nitrogen to which A and Y are attached to form a five or six membered ring which may contain oxygen or a double bond, and which may have attached thereto R8 which is methyl or methylene; and, R2 is wherein R3, R4, R5, R6, R7, R9, R10 and R25 are each independently H, CH3, CH2NH2, CH2NHCH3 or CH2NHC2H5, and R5, R6, R7, and R9 may also independently be NH2, NHCH3 or NHC2H5.