1346746-81-3

Basic information

• Product Name: phenylethanolaMine A
• Synonyms: phenylethanolaMine A;Phenylethanolamine A Solution, 100ppm;Phenylethanolamine A Solution, 1000ppm
• CAS NO: 1346746-81-3
• Molecular Formula: C19H24N2O4
• Molecular Weight: 344.4
• Mol File: 1346746-81-3.mol

Chemical Properties

• Boiling Point: 519.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.178±0.06 g/cm3(Predicted)
• PKA: 14.02±0.20(Predicted)
• CAS DataBase Reference: phenylethanolaMine A(CAS DataBase Reference)
• NIST Chemistry Reference: phenylethanolaMine A(1346746-81-3)
• EPA Substance Registry System: phenylethanolaMine A(1346746-81-3)

Safety Data

• Hazardous Substances Data: 1346746-81-3(Hazardous Substances Data)

Usage

Uses

Phenylethanolamine A is a β-agonist found in urine samples.

Upstream product

• 7409-30-5 p-nitrobenzylamine 
• 99721-51-4 4-(4-nitrophenyl)butan-2-amine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 20714-90-3 4-Methoxymandelic acid 
• 22374-89-6 (RS)-1-methyl-3-phenylpropylamine 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 61713-40-4 1-(ethoxycarbonyl)-1-(p-nitrobenzyl)-2-propanone 
• 30780-19-9 4-(4-nitrophenyl)butan-2-one 

Relevant articles and documents

Synthetic method of phenylethanolamine A

The invention discloses a method for preparing phenylethanolamine A. The method includes the following steps: 1) reacting p-methoxyacetophenone in an HBr/DMSO system to obtain acetophenone aldehyde monohydrate and acetophenone aldehyde; 2) subjecting the acetophenone aldehyde and 4(4-nitrophenyl)butane-2-amine to bimolecular substitution reaction, and subjecting an intermediate product obtained bythe reaction to reduction reaction by potassium borohydride to obtain the phenylethanolamine A. The method has the advantages that the reactions are simple, the reaction steps are reduced, and the high-yield phenylethanolamine A is obtained.

Preparation method of phenylethanolamine A

The invention discloses a preparation method of phenylethanolamine A. The preparation method comprises the following steps that firstly, a nucleophilic substitution reaction is conducted on nitrobenzyl bromide and ethyl acetoacetate to obtain a compound shown in a formula 1; secondly, under an acidic condition, the compound shown in the formula 1 is subjected to an acidic hydrolysis reaction to obtain a compound shown in a formula 2; thirdly, the compound shown in the formula 2 and formamide are subjected to a Leuckart reaction to obtain a compound shown in a formula 3; fourthly, a nucleophilic substitution reaction is conducted on the compound shown in the formula 3 and bromo-p-methoxyacetophenone; potassium borohydride or sodium borohydride is added into a nucleophilic substitution reaction system, and a reduction reaction is conducted to obtain the phenylethanolamine A. The preparation method is short in reaction route, the synthesis efficiency is high, the separation and purification steps are reduced, and mass production can be achieved.

Method for preparing phenylethanolamine compound intermediate

The invention discloses a method for preparing a phenylethanolamine compound intermediate. The method comprises the following steps: (1) carrying out a nitrifying reaction on 1-methyl-3-phenylpropylamine and a nitrifying reagent to obtain a 4-(4-nitrophenyl)-butan-2-amine and 4-(2-nitrophenyl)-butan-2-amine mixture; and (2) reacting the mixture obtained in step (1) with a compound of formula III,and separating the obtained reaction product to obtain the phenylethanolamine compound intermediate of formula I. The method for preparing the phenylethanolamine compound intermediate has the advantages of simplicity in operation, short route and few steps; and an o-nitro impurities generated in the nitrifying reaction can be easily removed after being reacted without separation and becoming corresponding amides, so the reaction yield and the product purity are high, and the industrial production of the product is facilitated.