- Highly potent HCV NS4B inhibitors with activity against multiple genotypes
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The exploration of novel inhibitors of the HCV NS4B protein that are based on a 2-oxadiazoloquinoline scaffold is described. Optimization to incorporate activity across genotypes led to a potent new series with broad activity, of which inhibitor 1 displayed the following EC50 values: 1a, 0.08 nM; 1b, 0.10 nM; 2a, 3 nM; 2b, 0.6 nM, 3a, 3.7 nM; 4a, 0.9 nM; 6a, 3.1 nM.
- Phillips, Barton,Cai, Ruby,Delaney, William,Du, Zhimin,Ji, Mingzhe,Jin, Haolun,Lee, Johnny,Li, Jiayao,Niedziela-Majka, Anita,Mish, Michael,Pyun, Hyung-Jung,Saugier, Joe,Tirunagari, Neeraj,Wang, Jianhong,Yang, Huiling,Wu, Qiaoyin,Sheng, Chris,Zonte, Catalin
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p. 2161 - 2166
(2014/04/03)
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- AMINO QUINOLINE DERIVATIVES INHIBITORS OF HCV
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A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the substituents are defined herein, and methods of treating HCV infection in a patient are disclosed.
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