- Synthesis and anti-inflammatory evaluation of some new 3,6-disubstituted-1, 2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles bearing pyrazole moiety
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In the present study, a new series of 3,6-disubstituted- 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles (4aj) have been synthesized by condensing 3-substituted-4-amino-5- mercapto-1,2,4-triazoles (1a-b) with various 3-substitutedpyrazole- 4-carboxylic acids (3
- Malladi, Shridhar,Isloor, Arun M.,Shetty, Prashanth,Fun, Hoong Kun,Telkar, Sandeep,Mahmood, Riaz,Isloor, Nishitha
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p. 3272 - 3280,9
(2020/08/20)
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- Synthesis, characterization, antioxidant, and anticancer studies of 6-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-3-[(2-naphthyloxy) methyl][1,2,4] triazolo[3,4-b][1,3,4]thiadiazole in HepG2 cell lines
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Triazolo- thiadiazoles exhibit a variety of pharmacological properties, due to their cytotoxicity. In continuation of a previous study on triazolo-thiadiazoles, the authors have synthesized a new thiadiazole, 6-[3-(4-chlorophenyl)- 1-H-pyrazol-4-yl]-3-[(2
- Sunil, Dhanya,Isloor, Arun M.,Shetty, Prakash,Satyamoorthy,Prasad, A.S.Bharath
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scheme or table
p. 1074 - 1080
(2012/05/19)
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- Synthesis of 3-substituted arylpyrazole-4-carboxylic acids
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A method was suggested for preparing previously unknown 3-aryl-substituted pyrazole-4-carboxylic acids, involving Vilsmeier formylation of semicarbazones of 26 available mono- and disubstituted acetophenones and 2-acetylthiophene followed by oxidation of
- Lebedev,Lebedeva,Sheludyakov,Kovaleva,Ustinova,Kozhevnikov
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p. 782 - 789
(2007/10/03)
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- Effect of Electron-withdrawing Groups on the Thermal Ring Opening of 3H-Pyrazoles to Diazoalkenes
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3-Cyano-3H-pyrazoles, bearing a cyano, a p-chlorophenyl, or a p-chlorobenzyl group at C-3, generated from elimination reaction of the corresponding dihydropyrazoles with a leaving group such as a chlorine or p-chlorobenzoyloxy group, gave diazolkene derivatives, resulting from the ring-opening of the 3H-pyrazoles.However, 3-methoxycarbonyl-3H-pyrazoles bearing a methoxycarbonyl, a p-chlorophenyl, or p-chlorobenzyl group at C-3, prepared in a similar manner, gave mainly 1-methoxycarbonyl-1H-pyrazole derivatives, resulting from migration of the 3-methoxycarbonyl group to the adjacent nitrogen within the generated 3H-pyrazoles.Treatment of 3H-pyrazoles (8a and 29b) and 5-substituted 1-methoxycarbonyl-1H-pyrazoles (10a and 31b) with triethylamine gave 3-substituted 1-methoxycarbonyl-1H-pyrazoles, resulting from migration of the methoxycarbonyl group to the remote nitrogen.
- Nakano, Yoshihiko,Ilamaguchi, Masashi,Nagai, Toshikazu
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p. 1701 - 1757
(2007/10/02)
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