136099-55-3Relevant articles and documents
Hepatic metabolism of diclofenac: Role of human CYP in the minor oxidative pathways
Bort, Roque,MacE, Katherine,Boobis, Alan,Gomez-Lechon, Maria-Jose.,Pfeifer, Andrea,Castell, Jose
, p. 787 - 796 (2007/10/03)
The aim of this study was to re-examine the human hepatic metabolism of diclofenac, with special focus on the generation of minor hydroxylated metabolites implicated in the idiosyncratic hepatotoxicity of the drug. Different experimental approaches were u
Synthesis of deuterium labelled 4'-hydroxydiclofenac
Waterhouse, Ian
, p. 1075 - 1083 (2007/10/03)
Diclofenac is a potentially useful substrate for the study of drug-drug interactions caused by modulation of the activity of specific isoforms of cytochrome P450. The synthesis of a deuterium labelled version of its principal human metabolite, 4'-hydroxydiclofenac, for use as an internal standard in LC-MS-MS studies, is described.