1364375-60-9Relevant articles and documents
Total synthesis of the COPD biomarker desmosine via stepwise Sonogashira cross-coupling reactions
Yamada, Haruka,Hayashi, Takahiro,Usuki, Toyonobu
, p. 673 - 683 (2015)
Desmosine, a COPD biomarker and elastin crosslinker, is a tetrasubstituted pyridinium amino acid. In this paper, the total synthesis of desmosine is described utilizing stepwise and regioselective palladium-catalyzed Sonogashira cross-coupling reactions o
Total synthesis of COPD biomarker desmosine that crosslinks elastin
Usuki, Toyonobu,Yamada, Haruka,Hayashi, Takahiro,Yanuma, Hiroto,Koseki, Yohei,Suzuki, Noriyuki,Masuyama, Yoshiro,Lin, Yong Y.
, p. 3233 - 3235 (2012/04/10)
Desmosine, a crosslinking amino acid of elastin, is an attractive biomarker for diagnosis of chronic obstructive pulmonary disease (COPD). In this study, the first total synthesis of (+)-desmosine was achieved in 11% overall yield in 13 steps utilizing st