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CAS

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137766-76-8

(R)-2-Phenylpiperazine, also known as 2-(1-piperazinyl)ethylbenzene, is a chemical compound with the molecular formula C10H15N. It is a piperazine derivative that serves as a building block in the synthesis of various pharmaceutical drugs. (R)-2-Phenylpiperazine features a piperazine ring with a phenyl group attached, classifying it as a psychoactive agent. It has been recognized for its potential anxiolytic and antidepressant effects, as well as its investigational use in treating schizophrenia and other psychiatric disorders. (R)-2-Phenylpiperazine's affinity for serotonin and dopamine receptors indicates its possible role as a neurotransmitter modulator, making (R)-2-Phenylpiperazine a significant compound in drug development with potential therapeutic applications.

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  • 137766-76-8 Structure

  • Basic information

    1. Product Name: (R)-2-Phenylpiperazine
    2. Synonyms:
    3. CAS NO:137766-76-8
    4. Molecular Formula: C10H14N2
    5. Molecular Weight: 162.235
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 137766-76-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 289.2 °C at 760 mmHg
    3. Flash Point: 169 °C
    4. Appearance: N/A
    5. Density: 0.997g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (R)-2-Phenylpiperazine(CAS DataBase Reference)
    10. NIST Chemistry Reference: (R)-2-Phenylpiperazine(137766-76-8)
    11. EPA Substance Registry System: (R)-2-Phenylpiperazine(137766-76-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 137766-76-8(Hazardous Substances Data)

137766-76-8 Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-Phenylpiperazine is used as a building block for the synthesis of various pharmaceutical drugs due to its chemical structure and psychoactive properties.
Used in Neurotransmitter Modulation:
(R)-2-Phenylpiperazine is used as a neurotransmitter modulator for its affinity to serotonin and dopamine receptors, which may contribute to its potential therapeutic effects in treating psychiatric disorders.
Used in Antidepressant and Anxiolytic Applications:
(R)-2-Phenylpiperazine is used as an anxiolytic and antidepressant agent, leveraging its psychoactive properties to potentially alleviate symptoms of anxiety and depression.
Used in Schizophrenia Treatment:
(R)-2-Phenylpiperazine is used in the investigational treatment of schizophrenia, where its effects on neurotransmitter systems may offer therapeutic benefits for managing the disorder.
Used in Drug Development Research:
(R)-2-Phenylpiperazine is used in research for drug development, exploring its potential as a compound with various therapeutic applications in the treatment of mental health conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 137766-76-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,7,6 and 6 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 137766-76:
(8*1)+(7*3)+(6*7)+(5*7)+(4*6)+(3*6)+(2*7)+(1*6)=168
168 % 10 = 8
So 137766-76-8 is a valid CAS Registry Number.

137766-76-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R)-2-Phenylpiperazine

1.2 Other means of identification

Product number -
Other names PIPERAZINE,2-PHENYL-,(2R)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:137766-76-8 SDS

137766-76-8Downstream Products

137766-76-8Relevant articles and documents

Biocatalytic Access to Piperazines from Diamines and Dicarbonyls

Borlinghaus, Niels,Gergel, Sebastian,Nestl, Bettina M.

, p. 3727 - 3732 (2018/04/14)

Given the widespread importance of piperazines as building blocks for the production of pharmaceuticals, an efficient and selective synthesis is highly desirable. Here we show the direct synthesis of piperazines from 1,2-dicarbonyl and 1,2-diamine substrates using the R-selective imine reductase from Myxococcus stipitatus as biocatalyst. Various N- and C-substituted piperazines with high activity and excellent enantioselectivity were obtained under mild reaction conditions reaching up to 8.1 g per liter.

Histone demethylase LSD1 (lysine specific demethylase 1) inhibitor

-

Paragraph 0025, (2017/09/29)

The invention provides a histone demethylase LSD1 (lysine specific demethylase 1) inhibitor. The invention relates to piperazine-containing compounds and pharmacologically acceptable salts thereof and use of the piperazine-containing compounds and pharmacologically acceptable salts thereof as the LSD1 inhibitor; the general structural formula of the piperazine-containing compounds is described in the description. The invention belongs to the field of pharmaceutical chemistry. An in-vitro LSD1 activity inhibition test proves that the piperazine-containing compounds implemented by the invention have an obvious inhibiting effect for LSD1 activity, thus being used as active ingredients for preparing LSD1 inhibitor medicines.

Benzo[1,8]naphthyridine derivatives, their preparation and compositions containing them

-

, (2008/06/13)

New benzo[b][1,8]naphthyridine derivatives of general formula (I), in which R1 is a hydrogen atom or a hydroxyl or alkyl radical, R2 is a hydrogen atom or an alkyl, fluoroalkyl, cycloalkyl (3 to 6 C), alkyloxy or alkylamino radical, R3 is a phenyl or phenylalkyl radical substituted with one or more halogen atoms or alkyl, cycloalkyl (3 to 6 C), alkyloxy, cyano, amino, alkylamino, dialkylamino, alkyloxyalkyl, hydroxyalkyl, hydroxyalkyloxy, methylenedioxy, aminoalkyl, alkylaminoalkyl or dialkylaminoalkyl radicals, or R3 is a heterocyclic radical, and R4 is a hydrogen atom or a fluorine atom, the alkyl radicals (1 to 4 C) being linear or branched, their salts, their preparation and compositions containing them. These new products are useful as antimicrobials, or in the treatment of AIDS. STR1

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