62779-69-5

Basic information

• Product Name: (R)-(-)-1,2-Diamino-1-phenylethane
• Synonyms: (R)-1-Phenyl-aethylendiamin;(R)-1-phenyletylenediamine;(R)-1-phenylethane-1,2-diamine;(R)-1-phenyl-ethanediyldiamine;(R)-2-Phenylethylenediamine;(R)-1-Phenyl-aethandiyldiamin
• CAS NO: 62779-69-5
• Molecular Formula: C8H12N2
• Molecular Weight: 136.197
• Mol File: 62779-69-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-(-)-1,2-Diamino-1-phenylethane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-1,2-Diamino-1-phenylethane(62779-69-5)
• EPA Substance Registry System: (R)-(-)-1,2-Diamino-1-phenylethane(62779-69-5)

Safety Data

• Hazardous Substances Data: 62779-69-5(Hazardous Substances Data)

Usage

General Description

(R)-(-)-1,2-Diamino-1-phenylethane, also known as (-)-1,2-Diaminopropane, is a chiral compound with the chemical formula C8H12N2. It is a diamine with two amino groups and a phenyl group attached to the carbon chain. (R)-(-)-1,2-Diamino-1-phenylethane is used in the synthesis of chiral ligands, chiral auxiliaries, and chiral building blocks for asymmetrical synthesis. It is also used as a chiral resolving agent and as a resolving reagent for organic compounds. The chiral nature of (R)-(-)-1,2-Diamino-1-phenylethane makes it useful in the production of enantiomerically pure products in various chemical reactions.

Upstream product

• 5700-56-1 1,2-diaminophenylethane 
• 19883-41-1 D-phenylglycine methyl ester hydrochloride 
• 70-11-1 α-bromoacetophenone 
• 4589-97-3 phenylglyoxime 
• 53641-61-5 1-phenyl-1-acetylamino-2-acetylaminoethane 
• 94165-04-5 ethyl (S)-3-benzamido-3-phenylpropionate 
• 40639-03-0 (S)-3-benzoylamino-3-phenyl-propionic acid amide 
• 3082-69-7 ethyl (3S)-3-amino-3-phenylpropionate 
• 24461-61-8 (R)-Phenylglycine methyl ester 

Downstream Products

• 129867-64-7 (R)-1,2-Di(acetylamino)-1-phenylethane 
• 137766-76-8 (R)-2-phenylpiperazine 
• 84866-37-5 (R)-N¹,N²-Dimethyl-1-phenyl-ethane-1,2-diamine 
• 1609286-13-6 (R)-N,N'-(1-phenylethane-1,2-diyl)bis(2-chloroacetamide) 
• 1609286-17-0 (3R)-1-(chloromethyl)-3-phenyl-4-aza-1-azoniabicyclo[2.2.2]octane trifluoromethanesulfonate 
• 1609286-15-8 (3R)-1-(chloromethyl)-3-phenyl-4-aza-1-azoniabicyclo[2.2.2]octane chloride 
• 1609286-14-7 (R)-2-phenyl-1,4-diazabicyclo[2.2.2]octane 
• 1280492-68-3 (R)-3-phenyl[1,2,5]thiadiazolidine-1,1-dioxide 
• 1017830-45-3 (R)-5-phenyl-2,3-piperazinedione 
• 170242-71-4 (1R)-[N,N'-bis(2'-hydroxybenzylidene)]-1-phenyl-1,2-diaminoethane 
• 95006-06-7 (R)-1.2-bis-benzamino-1-phenyl-ethane 

Relevant articles and documents

CHIRAL FLUORINATING REAGENTS

This invention relates to fluorinating agents and, more particularly, to chiral non-racemic fluorinating agents useful for enantioselective fluorination, as well as to their synthesis and use and other subject matter. The fluorinating agents are based on a substituted 1,4-diazabicyclo[2.2.2]octane (DABCO) skeleton and provide electrophillic fluorine enantioselectively.

Asymmetric molybdenum(0)-catalyzed allylic substitution

Application of new ligands (R)-(-)-8,(S)-(+)-16, and (S)-(+)-17 to the title reaction (1 or 2 → 3) led to excellent regio- and enantioselectivities (> 30:1; ≤ 98% ee); although lacking the C2-symmetry, the catalysts can be viewed as quasi-C2-symmetrical since the single chiral center is sufficient to determine the sense of wrapping of the metal by the ligand.