- New heteroaryl-spaced phosphono α-amino acids are competitive NMDA antagonists with analgesic activity
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The synthesis and the NMDA receptor binding affinities of α-amino-3-(phosphonomethyl)-2-naphthalenepropanoic acid, α-amino-3-(phosphonomethyl)-2-benzofuranpropanoic acid, a series of substituted (R)-α-amino-3-(phosphonomethyl)-2-quinolinepropanoic acids, (R)-α-amino-3-(phosphonomethyl)-1,8-naphthyridine-2-propanoic acid and (R)-α-amino-3-(phosphonomethyl)-1,6-naphthyridine-2-propanoic acid are reported.
- Swahn, Britt-Marie,Claesson, Alf,Pelcman, Benjamin,Besidski, Yevgeni,Molin, Hakan,Sandberg, Mats P.,Berge, Odd-Geir
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p. 1635 - 1640
(2007/10/03)
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- Side-chain Chlorination of Methylquinolines
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Methylquinolines 1-4 were chlorinated by heating with phosphorous pentachloride in chlorobenzene to side-chain halogen derivatives 5-14.Methyl groups of compounds 1-4 can be chlorinated to chloromethyl, dichloromethyl or trichloromethyl groups depending on their positions and the reaction conditions.
- Korodi, Ference
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p. 1549 - 1552
(2007/10/02)
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