137988-23-9

Basic information

• Product Name: Acetonitrile, (2-fluorophenoxy)- (9CI)
• Synonyms: Acetonitrile, (2-fluorophenoxy)- (9CI);2-(2-Fluorophenoxy)-acetonitrile
• CAS NO: 137988-23-9
• Molecular Formula: C₈H₆FNO
• Molecular Weight: 151.1377432
• Product Categories: HALIDE
• Mol File: 137988-23-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Acetonitrile, (2-fluorophenoxy)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Acetonitrile, (2-fluorophenoxy)- (9CI)(137988-23-9)
• EPA Substance Registry System: Acetonitrile, (2-fluorophenoxy)- (9CI)(137988-23-9)

Safety Data

• Hazardous Substances Data: 137988-23-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Manufacturing:
Acetonitrile, (2-fluorophenoxy)(9CI) is utilized as a solvent in pharmaceutical manufacturing for its ability to dissolve a wide range of substances, facilitating the production of various medications.
Used in Extraction Processes:
In extraction processes, Acetonitrile, (2-fluorophenoxy)(9CI) serves as a solvent to effectively separate and isolate specific compounds, which is crucial for the purification and concentration of target substances.
Used in Chemical Production:
Acetonitrile, (2-fluorophenoxy)(9CI) is employed in the production of various chemicals, acting as a key solvent that enables the synthesis and processing of a multitude of chemical products.
Used as a Starting Material for Synthesis:
Acetonitrile, (2-fluorophenoxy)(9CI) also functions as a starting material for the synthesis of other complex organic compounds, highlighting its importance in the field of organic chemistry.
Safety Precautions:
Given its potential health hazards, Acetonitrile, (2-fluorophenoxy)(9CI) should be handled with care in a well-ventilated area and used with appropriate personal protective equipment. Adherence to safety guidelines and regulations is essential when working with this chemical compound.

Upstream product

• 367-12-4 2-fluorophenol 
• 107-14-2 chloroacetonitrile 
• 590-17-0 cyanomethyl bromide 

Downstream Products

• 137374-74-4 3-(2-Fluoro-phenoxy)-7-hydroxy-chromen-4-one 
• 137988-08-0 Acetic acid 3-(2-fluoro-phenoxy)-4-oxo-4H-chromen-7-yl ester 
• 1532533-94-0 2-(2-fluorophenoxy)-1-(2,4,6-trihydroxyphenyl)ethanone 
• 137987-82-7 1-(2,4-dihydroxyphenyl)-2-(2-fluorophenoxy)ethanone 
• 1532534-17-0 1-(2,4-dihydroxy-5-methylphenyl)-2-(2-fluorophenoxy)ethanone 
• 1532534-42-1 C₁₇H₁₇FO₄ 
• 729-79-3 C-<2-Fluor-phenoxy>-acetanilid 

Relevant articles and documents

Combinatorial synthesis and in vitro evaluation of a biaryl hydroxyketone library as antivirulence agents against mrsa

Antibiotic resistance coupled with decreased development of new antibiotics necessitates the search for novel antibacterial agents. Antivirulence agents offer an alternative to conventional antibiotics. In this work, we report on a family of small-molecule antivirulence agents against methicillin-resistant Staphylococcus aureus (MRSA), the most widespread bacterial pathogen. Structure-activity relationship studies led to the development of a concise synthesis of a 148-member biarylhydroxyketone library. An acylation bond-forming process afforded resorcinols (1) and aryloxy acetonitriles (2) as synthons. A Lewis-acid-activated Friedel-Crafts' acylation step involving a nitrile functionality of 2 by ZnCl2, followed by nucleophilic attack by 1 was executed to obtain biaryl hydroxyketones in excellent yields. A large number of products crystallized. This strategy affords a range of biarylhydroxyketones in a single step. This is the first collective synthetic study documenting access to this class of compounds through a single synthetic operation. In vitro efficacy of compounds in this library was evaluated by a rabbit erythrocyte hemolysis assay. The most efficacious compound, 4f-12, inhibits hemolysis by 98.1 ± 0.1% compared to control in the absence of the compound.

Heterocyclic compounds as P2X7 ion channel blockers

The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: 1 wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer''s disease, etc.

POLY(ADP-RIBOSE) POLYMERASE INHIBITORS CONSISTING OF PYRIMIDINE DERIVATIVES

A medicament for therapeutic and/or preventive treatment of a brain disease, which comprises a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient: wherein R represents hydrogen atom, a C1-C8 alkyl group, a substituted C1-C8 alkyl group, an aryl group, a substituted aryl group, an aryl(C1-C8)alkyl group and the like; Y represents hydrogen atom or -C(R2)R3 (R2 and R3 represent hydrogen atom, a C1-C8 alkyl group, a C1-C8 alkoxy(C1-C8)alkyl group, a hydroxy(C1-C8)alkyl group and the like); symbol "a" represents single bond when Y represents hydrogen atom, or "a" represents double bound when Y represents -C(R2)R3; -A-B- represents -CH2-CH2-, -S-CH2-, -O-CH2-, -CH2-S-, -CH2-O-, -SO-CH2-, -CH2-SO-, -SO2-CH2-, or -CH2-SO2-; and Z represents -CH2- or single bond.