139112-38-2

Basic information

• Product Name: Tris-(2-MaleiMidoethyl)aMine(Trifunctional)(TMEA)
• Synonyms: Tris-(2-MaleiMidoethyl)aMine(Trifunctional)(TMEA)
• CAS NO: 139112-38-2
• Molecular Formula: C₁₈H₁₈N₄O₆
• Molecular Weight: 386.36
• Mol File: 139112-38-2.mol

Chemical Properties

• Boiling Point: 618.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.479±0.06 g/cm3(Predicted)
• PKA: 6.37±0.50(Predicted)
• CAS DataBase Reference: Tris-(2-MaleiMidoethyl)aMine(Trifunctional)(TMEA)(CAS DataBase Reference)
• NIST Chemistry Reference: Tris-(2-MaleiMidoethyl)aMine(Trifunctional)(TMEA)(139112-38-2)
• EPA Substance Registry System: Tris-(2-MaleiMidoethyl)aMine(Trifunctional)(TMEA)(139112-38-2)

Safety Data

• Hazardous Substances Data: 139112-38-2(Hazardous Substances Data)

Usage

Uses

Used in Polymer and Resin Production:
Tris-(2-MaleiMidoethyl)aMine(Trifunctional)(TMEA) is used as a crosslinking agent for enhancing the stability and properties of polymers and resins. Its trifunctional nature and high reactivity allow for the formation of strong covalent bonds, leading to improved structural integrity and performance of the final products.
Used in Nanoparticle Synthesis:
In the field of nanotechnology, TMEA is utilized in the synthesis of nanoparticles. Its ability to form stable crosslinked structures contributes to the development of nanoparticles with enhanced properties and applications.
Used in Bioconjugation and Biomaterials:
Tris-(2-MaleiMidoethyl)aMine(Trifunctional)(TMEA) is employed as a key component in bioconjugation processes due to its specific reactivity with thiol-containing molecules. This makes it suitable for the development of biomaterials that require precise molecular interactions and stable linkages.
Used in Organic Compound Synthesis:
TMEA serves as a building block in the synthesis of complex organic compounds. Its versatile reactivity is valuable in creating a wide range of functional materials with diverse applications across various industries.
Used in Chemical and Materials Science Research:
As a valuable tool in chemistry and materials science, TMEA is used in research to explore new methods of material synthesis, understand the properties of crosslinked structures, and develop innovative applications for maleimide-containing compounds.

Upstream product

• 55750-48-6 N-methoxycarbonylmaleimide 
• 4097-89-6 2,2',2''-triaminotriethylamine 
• 55750-49-7 N-ethoxycarbonylmaleinimide 
• 108-31-6 maleic anhydride 

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Reversible polymer composition

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A New Class of Bradykinin Antagonists: Synthesis and in Vitro Activity of Bissuccinimidoalkane Peptide Dimers

A systematic study on the dimerization of the bradykinin (BK) antagonist D-Arg0-Arg1-Pro2-Hyp3-Gly4-Phe5-Ser6-D-Phe7-Leu8-Arg9 has been performed.The first part of this study involved compounds wherein dimerization was carried out by sequentially replacing each amino acid with cysteine and cross-linking with bismaleimidohexane.The second part of this study utilized a series of bissuccinimidoalkane dimers wherein the intervening methylene chain was varied systematically from n = 2 to n = 12 while the point of dimerization was held constant at position 6.The biological activities of these dimers were then evaluated on BK-induced smooth muscle contraction in two different isolated tissue preparations: guinea pig ileum (GPI) and rat uterus (RU).Several of the dimeric BK antagonists displayed remarkable activites and long durations of action.In addition, dimerization at position 4, 7, 8, or 9 produced dimeric analogues with markedly reduced potency.Rank order of antagonist potency as a function of dimerization position is as follows: rat uterus, 6 > 5 > 0 > 2 > 1 >3 >> 4, 7, 8, 9; guinea pig ileum, 6 > 5 > 3 > 2 > 1 > 0 >> 4, 7, 8, 9.Evaluation of the linker length as represented by the number of methylene units indicated an optimal distance between the two monomeric peptides of six to eight methylene moieties.These studies also revealed that the carbon-chain length significantly affected the duration of action in vitro and resulted in partial agonism effects when n > 8.The optimum activity in vitro was achieved with dimerization at position 6 and n = 6 (designated herein as compound 25; alternatively, CP-0127).Similar effects in potency were also seen when the monomeric antagonist D-Arg0-Arg1-Pro2-Hyp3-Gly4-Phe5-Ser6-D-Phe7-Phe8-Arg9 (NPC-567) was dimerized using similar chemistry.These results suggest that the development of BK antagonists of significant therapeutic potential may be possible using a dimerization strategy that can overcome the heretofore limiting problems of potency and in vivo duration of action found with many of the BK antagonists in the literature.