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L-tert-Leucine hydrochloride is a white crystalline powder that is a derivative of the amino acid leucine. It is soluble in water and is commonly used in various applications due to its unique properties.

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  • 139163-43-2 Structure
  • Basic information

    1. Product Name: L-tert-Leucine hydrochloride
    2. Synonyms: L-TERT-LEUCINE HYDROCHLORIDE;(S)-2-amino-3,3-dimethylbutanoic acid hydrochlorid;(S)-2-Amino-3,3-dimethylbutanoic acid hydrochloride
    3. CAS NO:139163-43-2
    4. Molecular Formula: C6H13NO2*ClH
    5. Molecular Weight: 167.63
    6. EINECS: N/A
    7. Product Categories: Amino Acids & Deriv.;CHIRAL CHEMICALS
    8. Mol File: 139163-43-2.mol
  • Chemical Properties

    1. Melting Point: >300°C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Inert atmosphere,Room Temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: L-tert-Leucine hydrochloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: L-tert-Leucine hydrochloride(139163-43-2)
    11. EPA Substance Registry System: L-tert-Leucine hydrochloride(139163-43-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 139163-43-2(Hazardous Substances Data)

139163-43-2 Usage

Uses

Used in Organic Synthesis:
L-tert-Leucine hydrochloride is used as a chiral auxiliary in organic synthesis for its ability to influence the stereochemistry of reactions, particularly in the production of pharmaceuticals and agrochemicals.
Used in Chemical Compound Preparation:
L-tert-Leucine hydrochloride serves as a building block in the preparation of other chemical compounds, contributing to the development of new materials and substances.
Used in Peptide and Peptidomimetic Synthesis:
It is utilized in the synthesis of peptides and peptidomimetics, which are important in the creation of bioactive molecules and potential drug candidates.
Used in Scientific Research:
L-tert-Leucine hydrochloride is studied for its potential anti-cancer and neuroprotective properties, making it a compound of interest for research in the fields of medicine and biology.

Check Digit Verification of cas no

The CAS Registry Mumber 139163-43-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,1,6 and 3 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 139163-43:
(8*1)+(7*3)+(6*9)+(5*1)+(4*6)+(3*3)+(2*4)+(1*3)=132
132 % 10 = 2
So 139163-43-2 is a valid CAS Registry Number.

139163-43-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name L-tert-Leucine hydrochloride

1.2 Other means of identification

Product number -
Other names L-tert-leucine HCl salt

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:139163-43-2 SDS

139163-43-2Relevant articles and documents

Recyclable Ligands for the Non-Enzymatic Dynamic Kinetic Resolution of Challenging α-Amino Acids

Nian, Yong,Wang, Jiang,Zhou, Shengbin,Wang, Shuni,Moriwaki, Hiroki,Kawashima, Aki,Soloshonok, Vadim A.,Liu, Hong

supporting information, p. 12918 - 12922 (2015/11/02)

Structurally simple and inexpensive chiral tridentate ligands were employed for substantially advancing the purely chemical dynamic kinetic resolution (DKR) of unprotected racemic tailor-made α-amino acids (TM-α-AAs), enabling the first DKR of TM-α-AAs bearing tertiary alkyl chains as well as multiple unprotected functional groups. Owing to the operationally convenient conditions, virtually complete stereoselectivity, and full recyclability of the source of chirality, this method should find wide applications for the preparation of TM-α-AAs, especially on large scale. The non-enzymatic dynamic kinetic resolution of racemic α-amino acids bearing tertiary alkyl chains and multiple unprotected functional groups is based on the enantioselective formation of nickel(II) complexes and their hydrolysis under convenient conditions. The specially designed chiral ligands are inexpensive and can be quantitatively recycled.

A process for the preparation of enantiomerically pure tert-leucine

-

Page/Page column 4, (2012/10/18)

A Process for the Preparation of Enantiomerically Pure tert-Leucine : Enantiomerically pure L-tert-leucine and D-tert-leucine were prepared from (DL)-tert-leucine by diastereomeric salt formation using dibenzoyl-d-tartaric acid as the resolving agent.

PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE tert-LEUCINE

-

Page/Page column 3, (2012/10/08)

Enantiomerically pure L-tert-leucine and D-tert-leucine were prepared from (DL)-tert-leucine by diastereomeric salt formation using dibenzoyl-d-tartaric acid as the resolving agent.

Azapeptide derivatives as HIV protease inhibitors

-

Page/Page column 40, (2009/01/24)

This invention relates to novel compounds of the Formula Ib: that are azapeptides, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel azapeptide compounds that are derivatives of the HIV protease inhibitor atazanavir sulfate. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and a carrier, and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administering HIV protease inhibitors. The invention also relates to the use of one or more of the disclosed compounds as reagents in analytical studies involving atazanavir.

Catalytic asymmetric acylcyanation of imines

Pan, Subhas Chandra,Zhou, Jian,List, Benjamin

, p. 612 - 614 (2008/02/01)

(Chemical Equation Presented) The less problematic acetyl cyanide can be used instead of toxic HCN for the highly enantioselective acyl-Strecker-type reaction. In the presence of an N-benzylimine and a catalytic amount of Jacobsen's catalyst 1, the desire

Oxidative rearrangement of 2-substituted oxazolines. A novel entry to 5,6-dihydro-2H-1,4-oxazin-2-ones and morpholin-2-ones

Shafer,Molinski

, p. 2044 - 2050 (2007/10/03)

A novel synthesis of 5,6-dihydro-2H-1,4-oxazin-2-ones by SeO2-promoted oxidative rearrangement of 2-alkyl- and 2-(arylmethyl)oxazolines is described. Yields are good to excellent (up to 94%) with the highest yields obtained for 2-arylmethyl- and 2-neopentyl-substituted oxazolines. This reaction provides convenient access to novel 5-aryl-substituted dihydrooxazinones in high yield. The latter compounds are important 'chiral glycine' synthons for asymmetric synthesis of α-amino acids. Since oxazolines are readily derived from carboxylic acids or their equivalents, this oxidative rearrangement constitutes an entry to synthesis of α-amino acids from carboxylic acids. A mechanism is proposed to account for the rearrangement involving a 'nitrilium to acylium' 1,2-migration.

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