139585-48-1

Basic information

• Product Name: 2-CHLORO-5-METHOXYPYRIDINE
• Synonyms: 2-CHLORO-5-METHOXYPYRIDINE;Pyridine, 2-chloro-5-methoxy- (9CI)
• CAS NO: 139585-48-1
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57
• EINECS: -0
• Product Categories: PYRIDINE;blocks;Pyridines;Boronic Acid;Pyridine Series
• Mol File: 139585-48-1.mol

Chemical Properties

• Boiling Point: 213.7±20.0℃ (760 Torr)
• Flash Point: 83.1±21.8℃
• Appearance: Colorless to light yellow liquid
• Density: 1.210±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.236mmHg at 25°C
• Refractive Index: 1.517
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.22±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-METHOXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-METHOXYPYRIDINE(139585-48-1)
• EPA Substance Registry System: 2-CHLORO-5-METHOXYPYRIDINE(139585-48-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 139585-48-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liquid

InChI:InChI=1/C6H6ClNO/c1-9-5-2-3-6(7)8-4-5/h2-4H,1H3

Upstream product

• 41288-96-4 6-chloropyridine-3-ol 
• 74-88-4 methyl iodide 
• 10167-97-2 2-amino-5-methoxypyridine 
• 638352-78-0 1-(5-methoxypyridin-2-yl)-2,5-dimethyl-1H-pyrrole 
• 477889-91-1 1-(5-iodopyridin-2-yl)-2,5-dimethyl-1H-pyrrole 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 

Downstream Products

• 741287-82-1 2-hydrazinyl-5-methoxypyridine 
• 1334176-44-1 methyl 2-[(2-methoxyethoxy)methoxy]-3-(5-methoxypyridin-2-ylamino)benzoate 
• 1220631-51-5 5-methoxy-N-(4-methoxybenzyl)pyridine-2-amine 
• 89809-63-2 5-methoxypyridine-2-carbonitrile 
• 1578264-36-4 C₁₅H₁₈N₂O₂ 
• 330473-71-7 6-(dimethylamino) pyridin-3-ol 
• 53698-54-7 5-methoxyl-2-phenylpyridine 
• 139585-64-1 5-methoxy-2-(trimethylsilyl)pyridine 
• 39858-87-2 5,5′-dimethoxy-2,2′-bipyridine 
• 1622456-79-4 C₁₉H₃₁NOP⁽¹⁺⁾*BF₄^(1-) 
• 69634-23-7 N-(5-methoxypyridin-2-yl)benzamide 
• 1210868-14-6 2-(benzylsulfanyl)-5-methoxypyridine 

Relevant articles and documents

Photoredox Properties of Homoleptic d6 Metal Complexes with the Electron-Rich 4,4′,5,5′-Tetramethoxy-2,2′-bipyridine Ligand

A synthetic procedure leading to 4,4′,5,5′-tetramethoxy-2,2′-bipyridine [(MeO)4bpy] was developed, and the first three metal complexes with this ligand were synthesized. A few ligand precursor compounds, the final ligand, and its homoleptic iron(II) complex were characterized structurally by X-ray diffraction. The combination of cyclic voltammetry, optical absorption, luminescence, and transient absorption spectroscopy provided detailed insight into the electronic structure of the entire series of homoleptic FeII, RuII, and OsII complexes. The ruthenium(II) complex is a more potent photoreductant than the [Ru(bpy)3]2+ parent compound by approximately 0.4 V as confirmed by 3MLCT excited-state quenching experiments with a relatively mild oxidant, 1-chloro-4-nitrobenzene. In the presence of methanesulfonic acid in CH3CN, the photoexcited [Ru{(MeO)4bpy}3]2+ complex is able to undergo proton-coupled electron transfer (PCET) with acetophenone to yield a ketyl radical. Chemically robust and potent photoreductants are of interest for the phototriggering of electron-transfer reactions, for example, in photoredox catalysis, in dye-sensitized solar cells, in fundamental studies of (proton-coupled) electron transfer, or for the generation of solvated electrons.

THERAPEUTIC COMPOUNDS AND METHODS OF USE

The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS

The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.

1-(2-hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile derivatives as potent and tissue selective androgen receptor modulators

We present a novel series of selective androgen receptor modulators (SARMs) which shows excellent biological activity and physical properties. 1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)-indoline-4-carbonitriles showed potent binding to the androgen receptor (AR) and activated AR-mediated transcription in vitro. Representative compounds demonstrated diminished activity in promoting the intramolecular interaction between the AR carboxyl (C) and amino (N) termini. This N/C-termini interaction is a biomarker assay for the undesired androgenic responses in vivo. In orchidectomized rats, daily administration of a lead compound from this series showed anabolic activity by increasing levator ani muscle weight. Importantly, minimal androgenic effects (increased tissue weights) were observed in the prostate and seminal vesicles, along with minimal repression of circulating luteinizing hormone (LH) levels and no change in the lipid and triglyceride levels. This lead compound completed a two week rat toxicology study, and was well tolerated at doses up to 100 mg/kg/day, the highest dose tested, for 14 consecutive days.

Fluorene Compound and Pharmaceutical Use Thereof

The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ische

AMIDOPYRAZOLE DERIVATIVE

A platelet coagulation inhibitor which inhibits neither COX-1 nor COX-2 is provided. The inhibitor is a compound represented by general formula (I): wherein Ar1 and Ar2 independently represent a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents, or a phenyl group optionally substituted with 1 to 3 substituents; R1 represents a lower acyl group, carboxyl group, a lower alkoxycarbonyl group, a lower alkoxy group, a lower alkyl group optionally substituted with 1 or 2 substituents, a carbamoyl group optionally substituted with 1 or 2 substituents, an oxamoyl group optionally substituted with 1 or 2 substituents, an amino group optionally substituted with 1 or 2 substituents, a 4- to 7-membered alicyclic heterocyclic group optionally substituted with 1 or 2 substituents, a phenyl group optionally substituted with 1 to 3 substituents, or a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents; and R2 represents hydrogen atom, a halogeno group, or the like.

Synthesis of Differently Disubstituted 2,2′-Bipyridines by a Modified Negishi Cross-Coupling Reaction

A general practical approach to a number of differently disubstituted 2,2′-bipyridines from substituted 2-bromo- and 2-chloropyridines by application of modified Negishi cross-coupling conditions has been developed. These 2,2′-bipyridines carry versatile functional groups that can be elaborated further, as demonstrated for some examples. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

On the Mechanism of the Carbodesilylation of 4- or 5-Substituted 2-(Trimethylsilyl)pyridines

An "ylide mechanism" is proposed for the carbodesilylation of 2-(trimethylsilyl)pyridines with benzaldehyde.In contrast, 3- and 4-(trimethylsilyl)pyridines, react only in the presence of a base catalyst via pyridyl anions with electrophiles.The rates of the uncatalyzed carbodesilylation reactions of 4-substituted 2-(trimethylsilyl)pyridines 2 with benzaldehyde correlate very well with the resonance parameters of the substituents ?0R, whereas the rates of 5-substituted 2-(trimethylsilyl)pyridines 7 correlate with the inductive substituent parameters ?1 in the Taft equation.This is to our knowledge the first direct determination of the resonance parameters ?0R.Key Words: Pyridines, substituted 2-(trimethylsilyl)-, synthesis of, carbodesilylation of / Carbodesilylation / Rate constants