89809-63-2

Basic information

• Product Name: 2-Cyano-5-methoxypyridine
• Synonyms: 5-methoxypyridine-2-carbonitrile;5-Methoxy-2-Pyridinecarbonitrile;2-Cyano-5-methoxypyridine, 5-Methoxypicolinonitrile;5-Methoxypicolinonitrile;2-PYRIDINECARBONITRILE, 5-METHOXY
• CAS NO: 89809-63-2
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.14
• EINECS: 200-589-5
• Mol File: 89809-63-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 280.8oC at 760 mmHg
• Flash Point: 123.6oC
• Appearance: /
• Density: 1.115g/cm3
• Vapor Pressure: 0.0037mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -4.06±0.10(Predicted)
• CAS DataBase Reference: 2-Cyano-5-methoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyano-5-methoxypyridine(89809-63-2)
• EPA Substance Registry System: 2-Cyano-5-methoxypyridine(89809-63-2)

Safety Data

• Hazardous Substances Data: 89809-63-2(Hazardous Substances Data)

Usage

General Description

2-Cyano-5-methoxypyridine is a chemical compound with the molecular formula C7H6N2O. It is a pyridine derivative, containing a cyano group and a methoxy group. 2-Cyano-5-methoxypyridine is used in the pharmaceutical industry as a building block in the synthesis of various pharmaceutical products. It is also used in organic synthesis as a reagent for creating different chemical compounds. 2-Cyano-5-methoxypyridine has the potential to exhibit various biological activities and is therefore a subject of research into its potential pharmaceutical applications. Additionally, it is important to handle this chemical with care and adhere to proper safety measures when working with it.

InChI:InChI=1/C8H8N2O/c1-11-8-3-2-7(4-5-9)10-6-8/h2-3,6H,4H2,1H3

Upstream product

• 67-56-1 methanol 
• 97483-77-7 2-Cyano-5-bromopyridine 
• 41288-96-4 6-chloropyridine-3-ol 
• 557-21-1 zinc(II) cyanide 
• 139585-48-1 2-chloro-5-methoxypyridine 
• 327056-62-2 5-fluoropicolinonitrile 
• 124-41-4 sodium methylate 
• 74-88-4 methyl iodide 
• 14906-61-7 3-methoxypyridine N-oxide 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 29082-92-6 5-methoxypyridine-2-carboxylic acid 
• 327056-65-5 5-methoxypyrid-2-ylamidoxime 

Relevant articles and documents

Solar-driven tandem photoredox nickel-catalysed cross-coupling using modified carbon nitride

Nickel-catalysed aryl amination and etherification are driven with sunlight using a surface-modified carbon nitride to extend the absorption of the photocatalyst into a wide range of the visible region. In contrast to traditional homogeneous photochemical methodologies, the lower cost and higher recyclability of the metal-free photocatalyst, along with the use of readily available sunlight, provides an efficient and sustainable approach to promote nickel-catalysed cross-couplings. This journal is

1-(2-hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile derivatives as potent and tissue selective androgen receptor modulators

We present a novel series of selective androgen receptor modulators (SARMs) which shows excellent biological activity and physical properties. 1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)-indoline-4-carbonitriles showed potent binding to the androgen receptor (AR) and activated AR-mediated transcription in vitro. Representative compounds demonstrated diminished activity in promoting the intramolecular interaction between the AR carboxyl (C) and amino (N) termini. This N/C-termini interaction is a biomarker assay for the undesired androgenic responses in vivo. In orchidectomized rats, daily administration of a lead compound from this series showed anabolic activity by increasing levator ani muscle weight. Importantly, minimal androgenic effects (increased tissue weights) were observed in the prostate and seminal vesicles, along with minimal repression of circulating luteinizing hormone (LH) levels and no change in the lipid and triglyceride levels. This lead compound completed a two week rat toxicology study, and was well tolerated at doses up to 100 mg/kg/day, the highest dose tested, for 14 consecutive days.

PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF COMPLEX DISEASES AND THEIR DELIVERY BY INSERTABLE MEDICAL DEVICES

The present invention relates to polyphenol-like compounds that are useful for inhibiting VCAM-1 expression, MCP-1 expression and/or SMC proliferation in a mammal. The disclosed compounds are useful for regulating markers of inflammatory conditions, including vascular inflammation, and for treatment and prevention of inflammatory and cardiovascular diseases and related disease states.