- Synthesis of oligo(spiroketal)s by polycondensation of silyl ethers derived from naturally occurring myo-inositol with 1,4-cyclohexanedione
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Oligo(spiroketal)s (OSKs) were synthesized from myo-inositol, a naturally occurring cyclic compound bearing six hydroxyl groups. The successful synthesis of OSKs was achieved using silyl ethers 2 derived from 1,4-di-O-alkylated myo-inositol 1 as monomers,
- Sudo, Atsushi,Yamasaki, Tomoki,Yamashita, Takuro,Ishida, Dai
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p. 2407 - 2414
(2019/08/12)
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- Synthetic Inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery
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Diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) is one of the mammalian PPIP5K isoforms responsible for synthesis of diphosphoinositol polyphosphates (inositol pyrophosphates; PP-InsPs), regulatory molecules that function at the interface of cell s
- Wang, Huanchen,Godage, Himali Y.,Riley, Andrew M.,Weaver, Jeremy D.,Shears, Stephen B.,Potter, Barry V.L.
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p. 689 - 699
(2014/06/09)
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- Design and synthesis of lipid-coupled inositol 1,2,3,4,5,6-hexakisphosphate derivatives exhibiting high-affinity binding for the HIV-1 MA domain
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The precursor of Gag protein (Pr55Gag) of human immunodeficiency virus, the principal structural component required for virus assembly, is known to bind d-myo-phosphatidylinositol 4,5-bisphosphate (PIP2). The N-terminus of Pr55G
- Tateishi, Hiroshi,Anraku, Kensaku,Koga, Ryoko,Okamoto, Yoshinari,Fujita, Mikako,Otsuka, Masami
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p. 5006 - 5022
(2014/07/07)
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- On the kinetic resolution of sterically hindered myo-inositol derivatives in organic media by lipases
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Sterically hindered myo-inositol derivatives were assayed against different commercial lipases. It was found that dl-1,3,6-tri-O-benzyl-myo-inositol undergoes efficient kinetic resolutions mediated by Pseudomonas sp. lipases (PS-C, PS-IM) and CaLB (Novozy
- Manoel, Evelin A.,Pais, Karla C.,Cunha, Aline G.,Coelho, Maria Alice Z.,Freire, Denise M.G.,Simas, Alessandro B.C.
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experimental part
p. 47 - 52
(2012/05/20)
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- Tetrakisphosphates and Bispyrophosphates of myo-Inositol Derivatives as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Oxygen Release
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Various 2,5- and 1,4-substituted and unsubstituted myo-inositol tetrakisphosphates and bispyrophosphates were prepared following a general synthetic pathway. All final compounds were tested for their capability to induce oxygen release from human hemoglob
- Koumbis, Alexandros E.,Duarte, Carolina D.,Nicolau, Claude,Lehn, Jean-Marie
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p. 169 - 180
(2013/01/09)
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- CYCLITOLS AND THEIR DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS
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The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate derivatives of inositol and other similar, more lipophilic derivatives, and their use as allosteric effectors, cell-signaling molecule analogs, and therapeutic agents.
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Page/Page column 33; 50
(2008/12/07)
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- Synthesis of potent Ins(1,4,5)P3 5-phosphatase inhibitors by modification of myo-inositol 1,3,4,6-tetrakisphosphate
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Three myo-inositol tetrakisphosphate analogues were synthesised based upon myo-inositol 1,3,4,6-tetrakisphosphate: 2,5-di-O-methyl myo-inositol-1,3,4,6-tetrakisphosphate 19 and its phosphorothioate derivative 22, together with myo-inositol 1,3,4,6 tetraki
- Mills, Stephen J.,Potter, Barry V. L.
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p. 4245 - 4253
(2007/10/03)
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- The preparation and phosphorylation of 2,5- and 1D-2,6-di-O-benzyl-myo-inositol
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1,3,4,6-Tetra-O-allyl-myo-inositol was converted into the 2,5-di-O-benzyl- and 2,5-di-O-p-methoxybenzyl ethers, and the products were deallylated to give the 2,5-di-O-benzyl (and p-methoxybenzyl) ethers of myo-inositol, which were converted into the mono-
- Desai,Gigg,Gigg,Payne
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- Total synthesis of myo-inositol polyphosphates from benzene via conduritol B derivatives
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The four (±)-myo-inositol phosphates 1,4,5-IP3 (1), 2,4,5-IP3 (15), 1,2,4,5-IP4 (17) and 4,5-IP2 (19) have been synthesised from benzene, using the protected conduritol B (10) as the key intermediate.
- Carless, Howard A. J.,Busia, Kofi
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p. 3449 - 3452
(2007/10/02)
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- TOTAL SYNTHESIS OF chiro-INOSITOL 2,3,5-TRISPHOSPHATE: A myo-INOSITOL 1,4,5-TRISPHOSPHATE ANALOGUE FROM BENZENE VIA PHOTO-OXIDATION
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The inositol tris- and tetrakis-phosphate analogues (4) and (14) have been synthesized from benzene by a sequence including reaction of singlet oxygen with a trans-cyclohexa-3,5-diene-1,2-diol (3) derivative.
- Carless, Howard A. J.,Busia, Kofi
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p. 1617 - 1620
(2007/10/02)
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- The Allyl Group for Protection in Carbohydrate Chemistry. Part 18. Allyl and Benzyl Ethers of myo-Inositol. Intermediates for the Synthesis of myo-Inositol Triphosphates
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Racemic 1,2:4,5-di-O-isopropylidene-myo-inositol was converted into racemic 1,2,4-tri-O-benzyl-myo-inositol, 1,2,4-tri-O-p-methoxybenzyl-myo-inositol and 2,4,5-tri-O-benzyl-myo-inositol using allyl groups for 'temporary' protection.The benzyl ethers are required as intermediates for the synthesis of the 'second messenger', inositol 1,4,5-triphosphate and its metabolite, inositol 1,3,4-triphosphate. 1,2,3,4-Tetra-O-benzyl-myo-inositol, and its two monoallyl and monoprop-1-enyl ethers, were also prepared as model compounds for phosphorylation studies of the vicinal 5,6-diol system which occurs in 1,2,4-tri-O-benzyl-myo-inositol.
- Gigg, Jill,Gigg, Roy,Payne, Sheila,Conant, Robert
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p. 423 - 430
(2007/10/02)
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- TOTAL SYNTHESIS OF OPTICALLY ACTIVE MYO-INOSITOL 1,4,5-TRIS(PHOSPHATE)
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Optically active myo-inositol 1,4,5-tris(phosphate) has been synthesized starting from myo-inositol.
- Ozaki, Shoichiro,Watanabe, Yutaka,Ogasawara, Tomio,Kondo, Yoshihisa,Shiotani, Naokazu,et al.
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p. 3157 - 3160
(2007/10/02)
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