1415564-99-6

Basic information

• Product Name: 5-((4-broMo-2-fluorophenyl)aMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylic acid
• Synonyms: 5-((4-broMo-2-fluorophenyl)aMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylic acid;potassium 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate
• CAS NO: 1415564-99-6
• Molecular Formula: C₁₅H₁₀BrF₂N₃O₂
• Molecular Weight: 382.1596064
• Mol File: 1415564-99-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-((4-broMo-2-fluorophenyl)aMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-((4-broMo-2-fluorophenyl)aMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylic acid(1415564-99-6)
• EPA Substance Registry System: 5-((4-broMo-2-fluorophenyl)aMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylic acid(1415564-99-6)

Safety Data

• Hazardous Substances Data: 1415564-99-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylic acid is used as a potential pharmaceutical agent for its possible pharmacological properties. Its unique chemical structure suggests that it could be developed into a drug candidate for treating various diseases or conditions, pending further research and development.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylic acid serves as a valuable target for investigation. Scientists can explore its potential interactions with biological targets, such as enzymes or receptors, to understand its therapeutic potential and optimize its properties for specific medical applications.

Upstream product

• 606143-94-6 4-amino-3-fluoro-2-(2-fluoro-phenylamino)-5-nitro-benzoic acid methyl ester 
• 348-54-9 2-Fluoroaniline 
• 284030-58-6 4-Amino-2,3-difluoro-5-nitro-benzoic acid methyl ester 
• 105931-73-5 1-bromo-3-fluoro-4-iodobenzene 
• 918321-20-7 methyl 5-amino-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate 
• 1415559-93-1 methyl 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate 

Downstream Products

• 606143-89-9 6-(4-bromo-2-fluoro-phenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxy-ethoxy)-amide 
• 1604812-73-8 C₁₈H₁₂BrF₂N₅O 

Relevant articles and documents

PROCESS OF PREPARATION OF BENZIMIDAZOLE COMPOUNDS

The application provides process of preparation of benzimidazole compounds such as Binimetinib and Selumetinib. Also, the present application provides intermediates for process of preparation of Binimetinib and Selumetinib.

PREPARATION OF AND FORMULATION COMPRISING A MEK INHIBITOR

The present invention relates to processes for preparing 6-(4-bromo-2- fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2- hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2- fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2- hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.

COMBINATION THERAPY

The present invention relates to a pharmaceutical combination comprising a MEK inhibitor compound 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)- amide or a pharmaceutically acceptable salt thereof and the IGFIR inhibitor ANTIBODY A, a pharmaceutical composition comprising such combination, methods for treating cancer comprising administration of a therapeutically effective amount of such combination to a subject in need thereof, and uses of such combination for the treatment of cancer.