cas 14161-11-6, 3,4,5-TRICHLOROPYRIDAZINE | Articles data

Articles about 14161-11-6Total 16 be found

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE
The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof. They are useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.
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Paragraph 000419

(2019/06/05)

Substituted heteroaryl compounds and compositions and uses thereof (by machine translation)
The invention discloses substituted heteroaryl compounds and compositions thereof and their use. The compounds of formula (I) compound or type shown in (I) a compound represented by stereo isomers, tautomers, nitrogen oxide, solvate, metabolite, pharmaceutically acceptable salt or its prodrug. The invention also provides a pharmaceutical composition, the compounds and pharmaceutical compositions can be regulated protein kinase, particularly Aurora kinase and JAK kinase activity, for the prevention, treatment, treatment and reduce protein kinase, in particular JAK kinase activity mediated diseases or disorders. (by machine translation)
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Paragraph 0817; 0819; 0120; 0820

(2019/06/07)

PROCESS FOR THE PRODUCTION OF PYRIDAZINYL-AMIDES IN A ONE-POT SYNTHESIS
Process for the production of compounds (I). their salts, tautomers, or enantiomers; by reaction of compounds (II) their salts, tautomers, or enantiomers; with compounds (III) their salts, tautomers, or enantiomers. And compounds III in the form of their HCl adducts.
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Page/Page column 31

(2018/05/24)

PROCESS FOR PREPARING 4-AMINO-PYRIDAZINES
The present invention relates to a process for preparing a pyridazine amine compound of formula V, and to processes for preparing dichloropyridazine amine compounds of formula IVa, IVb, or mixtures thereof. Furthermore, the present invention relates to the novel dichloropyridazine amine compounds of formula IVa, IVb,ormixtures thereof, wherein the amino group is an ethylamino group.
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Page/Page column 34

(2016/12/01)

IMIDAZOPYRIDAZINE DERIVATIVES AS MODULATORS OF THE GABAA RECEPTOR ACTIVITY.
The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R and R6 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.
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Page/Page column 66-67

(2016/01/01)

Chemical Compounds
The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.
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Paragraph 0451; 0452; 0453

(2014/06/25)

Access to 4-alkylaminopyridazine derivatives via nitrogen-assisted regioselective pd-catalyzed reactions
3-Substituted, 6-substituted, and unsymmetrical 3,6-disubstituted 4-alkylaminopyridazines were prepared from a sequence of three chemo- and regioselective reactions combining amination and palladium-catalyzed cross-coupling reactions, such as reductive dehalogenation and Suzuki-Miyaura reactions. Extension of the methodology to Sonogashira reaction yielded a novel class of 3-substituted pyrrolopyridazines.
Blaise, Emilie,Kümmerle, Arthur E.,Hammoud, Hassan,De Arajo-Jnior, Jo Xavier,Bihel, Frdric,Bourguignon, Jean-Jacques,Schmitt, Martine
p. 10311 - 10322
(2015/02/19)

TRICYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS
There is provided compounds of formula (I), wherein R1, R2, X, R3 and R4 have meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula (I).
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Page/Page column 70

(2013/03/26)

DIAMINO-PYRIDINE, PYRIMIDINE, AND PYRIDAZINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
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Page/Page column 193-195

(2010/01/07)

Process for the preparation of a 3(2H)-pyridazinone-4- substituted amino 5-chloro derivative
The invention relates to novel processes for the preparation of 5-chloro-4-{3-[N-[2-(3,4-dimethoxyphenyl)-ethyl]-N-methylamino]-propylamino-3(2H) pyridazinone of formula (I) and the pharmaceutically acceptable acid addition salts thereof. An important feature of the invention is using 3,4,5-trichloropyridazone as starting substance of the synthesis.
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Page column 12

(2008/06/13)

Nucleophilic substitution of chlorine with hydrazine and methylhydrazine in chlorinated pyridazines and pyridazones
The reactions of methylhydrazine and hydrazine hydrate with chlorinated pyridazines and pyridazones were studied.
Baranov,Tsypin,Malin,Laskin
p. 1997 - 2000
(2007/10/03)

N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists
Compounds represented by Formula (I): 1or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
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(2019/08/08)

Synthesis of 4,5-dichloro-1-(4,5-dichloropyridazin-3-yl)pyridazin-6-one
This paper presents the synthesis of 4,5-dichloro-1-(4,5- dichloropyridazin-3-yl)pyridazin-6-one from 4,5-dichloropyridazin-6-one.
Kweon, Deok-Heon,Kang, Young-Jin,Chung, Hyun-A.,Park, Jung-Won,Lee, Woo Song,Yoon, Yong-Jin,Kim, Sung-Kyu,Shiro, Motoo
p. 1301 - 1306
(2007/10/03)

REACTIONS OF CYCLOPROPENES WITH DIAZOMETHANE IN THE PRESENCE OF PALLADIUM COMPOUNDS
The reaction of cyclopropenes with diazomethane in the presence of palladium acetate leads to bicyclobutane isomerization products, to olefins containing 1,4-pentadiene fragments, and to the oligomers of cyclopropenes.The predominating reaction path is determined by the degree of substitution of the double bond.
Lukin, K. A.,Zefirov, N. S.
p. 242 - 246
(2007/10/02)

Pyridazinylurea plant regulators
Pyridazinylurea plant regulators of the formula STR1 and acid addition salts thereof; wherein R is alkyl or cycloalkyl, R1 is hydrogen or alkyl, each X independently is halogen, alkoxy, alkylthi or alkylsulfonyl, and p is 0, 1 or 2.
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(2008/06/13)