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141992-47-4

NSC 625987 is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

141992-47-4

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141992-47-4 Usage

Uses

NSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor.

Biological Activity

Cyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 0.2 μ M at cdk4/cyclin D1). Displays > 500-fold selectivity over cdk2 (IC 50 > 100 μ M for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).

Check Digit Verification of cas no

The CAS Registry Mumber 141992-47-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,9,9 and 2 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 141992-47:
(8*1)+(7*4)+(6*1)+(5*9)+(4*9)+(3*2)+(2*4)+(1*7)=144
144 % 10 = 4
So 141992-47-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H13NO2S/c1-17-11-7-8-12(18-2)14-13(11)15(19)9-5-3-4-6-10(9)16-14/h3-8H,1-2H3,(H,16,19)

141992-47-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,4-dimethoxy-10H-acridine-9-thione

1.2 Other means of identification

Product number -
Other names 1,4-Dimethoxy-9-thio(10H)-acridone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:141992-47-4 SDS

141992-47-4Relevant articles and documents

Structure-trypanodical activity relationships

Bsiri,Johnson,Kayirere,Galy,Galy,Barbe,Osuna,Mesa-Valle,Castilla Calvente,Rodriguez-Cabezas

, p. 27 - 33 (2007/10/03)

A set of 9-thioalkylacridinones, has been prepared and investigated' in vitro' against T. cruzi. Structure-antiparasitic activity relationships are detailed with a view to identify the major structural parameters for the activity under consideration.

1,4-Dimethoxy-9(10H)-acridinone derivatives. Synthesis, DNA binding studies and trypanocidal activity

Berny,Bsiri,Charbit,Galy,Soyfer,Galy,Barbe,Sharples,Mesa Valle,Mascaro,Osuna

, p. 674 - 679 (2007/10/02)

New acridinonic derivatives, which are hydroxy- and methoxy-substitutedin positions 1, 4, and 1,4 were prepared with a view to obtain antiparasitic drugs. These compounds were tested against Trypanosoma cruzi strains andtheir capability of intercalation into DNA was determined. Nucleus substitutions, DNA binding, and trypanocidal activities have been correlated.

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