143141-23-5

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)-;1-(Phenylsulfonyl)-7-azaindole;1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine;1-(Benzenesulfonyl)pyrrolo[2,3-b]pyridine;1-(Phenylsulphonyl)-7-azaindole;N-Benzenesulfonyl-7-azaindole
• CAS NO: 143141-23-5
• Molecular Formula: C₁₃H₁₀N₂O₂S
• Molecular Weight: 258.3
• Product Categories: Heterocycle-Pyridine series
• Mol File: 143141-23-5.mol

Chemical Properties

• Boiling Point: 465.8 °C at 760 mmHg
• Flash Point: 235.5 °C
• Appearance: /
• Density: 1.34 g/cm³
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)-(143141-23-5)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)-(143141-23-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 143141-23-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)is used as an inhibitor in pharmaceutical research for its potential to target specific enzymes and receptors. The phenylsulfonyl group attached to the pyrrolopyridine ring plays a crucial role in modulating the biological activity of the compound, making it a promising candidate for drug development.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)is utilized for its ability to target specific biological targets, contributing to the discovery and development of new drugs. Its unique structure and potential applications make it a valuable molecule for further exploration and studies in drug discovery.
Used in Organic Synthesis:
1H-Pyrrolo[2,3-b]pyridine, 1-(phenylsulfonyl)is also used in organic synthesis due to its unique structure and potential for further modification and functionalization. This allows for the development of new compounds with improved properties and applications in various fields, including pharmaceuticals and materials science.

Upstream product

• 271-63-6 7-Azaindole 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 861045-11-6 2-benzenesulfonylamino-nicotinic acid 
• 189089-88-1 (1-Benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-thiophen-2-yl-methanol 
• 189089-91-6 1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde 
• 189089-90-5 1-(phenyl-sulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid 
• 189089-86-9 (1-Benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-chloro-phenyl)-methanol 
• 189089-83-6 1-benzenesulfonyl-2-methyl-1H-pyrrolo[2,3-b]pyridine 
• 282734-63-8 2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 265647-76-5 1-(benzenesulfonyl)-2-(2-pyridyl)-7-azaindole 
• 880769-95-9 3-bromo-1-(benzenesulfonyl)-1H-pyrrolo [2,3-b]pyridine 
• 886547-96-2 3-(2-chloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 886546-35-6 cyclohexyl-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl]amine 

Relevant articles and documents

ESTROGEN RECEPTOR ANTAGONIST

Provided is an indole compound. In particular, disclosed are a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof and a use of the same as an estrogen receptor antagonist in preparing a drug for treating estrogen receptor-positive breast cancer.

Triazole glycoside derivative of 3-nitro-1-benzenesulfonyl-7-azaindole and preparation method and application thereof

The invention belongs to the technical field of medicines, and particularly relates to a triazole glycoside derivative of 3-nitro-1-benzenesulfonyl-7-azaindole and a preparation method and applicationthereof. The triazole glycoside derivative of 3-nitro-1

Design and synthesis of azaindole heterocycle decorated new scaffold in fluorometric sensing of F? and H2PO4?

7-Azaindole has been used in designing new molecular structure 1 on enediyne spacer for its application in anion sensing. New structure 1 has been established as efficient fluorescent sensor of H2PO4? and F? ion

Peptidylarginine deiminase inhibitor and application thereof

The invention belongs to the technical field of medicine, and particularly relates to a peptidylarginine deiminase PAD4 inhibitor compound shown in a formula (I) or pharmaceutically acceptable salts,stereoisomers and tautomers thereof, as well as pharmaceutical compositions, pharmaceutical preparations and application thereof. X, Y, R1, R2, R3, R4, R5, R7, R8, R9, ring B and m are as defined in the specification. The compound has inhibitory effect on peptidylarginine deiminase PAD4, and can be used for treating various diseases, such as rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, multiple sclerosis, cystic fibrosis, cancer, cutaneous lupus erythematosus, asthma and psoriasis.

Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors

From four molecules, inspired by the structural features of fascaplysin, with an interesting potential to inhibit cyclin-dependent kinases (CDKs), we designed a new series of tri-heterocyclic derivatives based on 1H-pyrrolo[2,3-b]pyridine (7-azaindole) an

MAP4K4 (HGK) Inhibitors

The invention provides mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) inhibitors, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant diminution of tumor cell growth, cancer or metastasis.

Palladium-Catalyzed Amination of N-Free 2-Chloro-7-azaindole

A simple and efficient procedure for the Pd-catalyzed amination of N-free 2-chloro-7-azaindole is described, using either primary or secondary amines. An optimized combination of Brettphos, a Brettphos precatalyst, and LiHMDS in THF led us to a novel methodology, applied to various functionalized amines to study the scope of the reaction. This is the first report of cross-coupling amination on N-free 2-chloro-7-azaindole.

ISOTOPICALLY ENRICHED AZAINDOLES

The present invention relates to a deuterated pyrrolo[2,3-b]pyridinyl compound that is useful for inhibiting Janus kinases. The invention also relates to processes and intermediates useful for preparing such a compound.

2-(AZAINDOL-2-YL)BENZIMIDAZOLES AS PAD4 INHIBITORS

Compounds of formula (I): wherein; R1 is hydrogen or C1-6alkyl;R2 is hydrogen, C1-6alkyl, perhalomethylC0-5alkyl-O—, or C1-6alkoxy;R3 is hydrogen, C1-6alkyl, or C1-6alkoxyC1-6alkyl;R4 is hydrogen, C1-6alkyl, perhalomethylC1-6alkyl; or unsubstituted C3-6cycloalkylC1-6 alkyl;A is C—R5 or N;B is C—R6 or N;D is C—R7 or N;with the proviso that at least one of A, B, and D, is N;R5 is hydrogen or C1-6alkyl;R6 is hydrogen or C1-6alkyl;R7 is hydrogen, C1-6alkyl, C1-6alkoxy, or hydroxy;R8 is hydrogen or C1-6alkyl, with the proviso that one of R4 and R8 is hydrogen;R9 is hydrogen or hydroxy;R10 is hydrogen or C1-6alkyl; and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.

Photochromism of new unsymmetrical diarylethenes based on the hybrid of azaindole and thiophene moieties

A new class of photochromic diarylethenes with both azaindole and thiophene moieties were synthesized to investigate the effects of the substituents on their photochromic behaviors, and their structures were determined by single crystal X-ray diffraction