143724-70-3Relevant articles and documents
The first total synthesis of sophoflavescenol, flavenochromane C, and citrusinol
Nguyen, Van-Son,Dong, Lin-Pei,Wang, Sheng-Chun,Wang, Qiuan
, p. 2297 - 2302 (2015/04/14)
The first total syntheses of sophoflavescenol (1), flavenochromane C (2), and citrusinol (3) were achieved. These three naturally occurring prenylated or prenyl-cyclized flavonoids have important biological activities such as cytotoxicity against some can
Effects of flavonoids on cell proliferation and caspase activation in a human colonic cell line HT29: An SAR study
Daskiewicz, Jean-Baptiste,Depeint, Flore,Viornery, Lionel,Bayet, Christine,Comte-Sarrazin, Geraldine,Comte, Gilles,Gee, Jennifer M.,Johnson, Ian T.,Ndjoko, Karine,Hostettmann, Kurt,Barron, Denis
, p. 2790 - 2804 (2007/10/03)
A library of 42 natural and synthetic flavonoids has been screened for their effect on cell proliferation and apoptosis in a human colonic cell line (HT-29). Examples of different classes of flavonoids have been screened, and the effects of hydroxylation, methoxylation and/or C-alkylation at various positions in the A- and B-rings have been assessed. Flavones and flavonols possess greater antiproliferative activity than chalcones and flavanones. With respect to structural modification of flavonoids, C-isoprenylation was by far the most effective, with substitution at the 8-position and longer chains, such as geranyl giving the best results. Finally, most compounds that significantly reduced cell survival also increased caspase activity, suggesting that at least part of their antiproliferative activity might be attributable to an apoptotic response.
1H-NMR CHEMICAL SHIFT OF THE FLAVONOL 5-HYDROXY PROTON AS A CHARACTERIZATION OF 6- OR 8-ISOPRENOID SUBSTITUTION
Fukai, Toshio,Nomura, Taro
, p. 1213 - 1225 (2007/10/02)
1H Nmr examination of 6- or 8-isoprenoid substituted flavonols has shown that the location of isoprenoid side chain on A ring can be deduced from the chemical shift of the 5-hydroxy proton.The application of this 1H nmr technique to identification of the