144282-41-7

Basic information

• Product Name: (S)-7-AMINO-5-BENZYL-4-OXO-5-AZASPIRO[2.4]HEPTANE
• Synonyms: (S)-7-AMINO-5-BENZYL-4-OXO-5-AZASPIRO[2.4]HEPTANE;(S)-7-Amino-5-benzyl-5-aza-spiro[2.4]heptan-4-one
• CAS NO: 144282-41-7
• Molecular Formula: C₁₃H₁₆N₂O
• Molecular Weight: 216.29
• Mol File: 144282-41-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-7-AMINO-5-BENZYL-4-OXO-5-AZASPIRO[2.4]HEPTANE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-7-AMINO-5-BENZYL-4-OXO-5-AZASPIRO[2.4]HEPTANE(144282-41-7)
• EPA Substance Registry System: (S)-7-AMINO-5-BENZYL-4-OXO-5-AZASPIRO[2.4]HEPTANE(144282-41-7)

Safety Data

• Hazardous Substances Data: 144282-41-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-7-AMINO-5-BENZYL-4-OXO-5-AZASPIRO[2.4]HEPTANE is used as a pharmaceutical candidate for its potential diverse biological activities. Its unique spirocyclic structure and functional groups may contribute to its therapeutic properties, warranting further research and development to explore its structure-activity relationships and potential applications in drug discovery and design.

Upstream product

• 180506-32-5 (R)-5-Benzyl-7-hydroxy-5-aza-spiro[2.4]heptan-4-one 
• 76315-01-0 N-benzyl-N-(tert-butoxycarbonyl)glycine 
• 129306-04-3 5-benzyl-5-azaspiro[2.4]heptane-4,7-dione 
• 220969-69-7 1-(2-Benzylamino-acetyl)-cyclopropanecarboxylic acid ethyl ester 
• 207554-16-3 4-(Benzyl-tert-butoxycarbonyl-amino)-3-oxo-butyric acid ethyl ester 
• 207554-17-4 1-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetyl]-cyclopropanecarboxylic acid ethyl ester 
• 32933-03-2 ethyl 1-acetylcyclopropanecarboxylate 
• 129306-05-4 ethyl 1-(2-bromoacetyl)cyclopropanecarboxylate 
• 161692-12-2 1-(2-acetoxy-1-oxoethyl)-1-ethoxycarbonylcyclopropane 

Downstream Products

• 127199-45-5 (7S)-5-azaspiro[2.4]heptan-7-ylcarbamic acid tert-butyl ester 
• 144282-35-9 5-benzyl-7(S)-amino-5-azaspiro[2,4]heptane 

Relevant articles and documents

Preparation method for efficiently synthesizing Sitafloxacin midbody (7S)-5-azaspiro[2.4] heptanes-7-phenylbutane

The invention discloses a preparation method for efficiently synthesizing Sitafloxacin midbody (7S)-5-azaspiro[2.4] heptanes-7-phenylbutane. The method comprises the following steps that a first material shown as the accompanying drawing takes a reaction to obtain a second material shown as the accompanying drawing; the second material takes a reaction to obtain a third material shown as the accompanying drawing; the third material takes a reaction to obtain a fourth material shown as the accompanying drawing; the fourth material takes a reaction to obtain a fifth material shown as the accompanying drawing. The preparation method has the advantages that the single compound with a high ee value can be obtained; the unnecessary waste of materials is avoided; the yield is obviously improved; the operation is simple; the industrial application is easy; the production cost is reduced.

Process for the preparation of optically active amines or salts thereof

A process produces an optically active amine or its salt and includes the steps of reacting a ketone of Formula (1a) 1wherein R1 is typically an unsubstituted or substituted hydrocarbon group; and R2a is typically a hydrocarbon grou

An efficient synthesis of a key intermediate of DU-6859a via asymmetric microbial reduction

An efficient synthetic method for the C-7 substituent of DU-6859a (1), which is a new-generation antibacterial quinolone carboxylic acid, was established by utilizing an enantioselective microbial reduction of 5- benzyl-4,7-dioxo-5-azaspiro[2,4]heptane (7) to the corresponding chiral alcohol (8) as the key reaction. This synthetic method was based on use of AIPHOS (Artificial Intelligence for Planning and Handling Organic Synthesis), which is a synthesis design system that generates suitable retrosynthetic routes from the standpoints of both novelty and practicality.