145451-91-8

Basic information

• Product Name: METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE
• Synonyms: METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE;(3S)-3-Hydroxy-2-(hydroxyMethyl)-N-(phenylMethyl)-D-leucine Methyl Ester;YVDOZNHDZMCBLR-DZGCQCFKSA-N
• CAS NO: 145451-91-8
• Molecular Formula: C₁₅H₂₃NO₄
• Molecular Weight: 281.35
• Product Categories: Chiral Reagents;Intermediates
• Mol File: 145451-91-8.mol

Chemical Properties

• Melting Point: 66-67°C
• Appearance: /
• Solubility: Acetone, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE(145451-91-8)
• EPA Substance Registry System: METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE(145451-91-8)

Safety Data

• Hazardous Substances Data: 145451-91-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE is used as a key intermediate in the synthesis of complex organic molecules. Its versatile structure allows for the formation of a wide range of compounds, making it a valuable asset in the field of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE is used as a building block for the development of new drugs. Its unique chemical properties enable the creation of novel drug candidates with potential therapeutic applications.
Used in Chemical Research:
METHYL (2R,3S)-2-BENZYLAMINO-3-HYDROXY-2-HYDROXYMETHYL-4-METHYLPENTANOATE is also utilized in chemical research to study the properties and reactivity of various organic compounds. Its use in research helps to advance the understanding of organic chemistry and contribute to the development of new synthetic methods and techniques.

Upstream product

• 100-52-7 benzaldehyde 
• 219691-06-2 (2R,3S)-2-Amino-3-hydroxy-2-hydroxymethyl-4-methyl-pentanoic acid 
• 145451-90-7 (2R,4R)-3-Benzyl-2-tert-butyl-4-((S)-1-hydroxy-2-methyl-propyl)-oxazolidine-4-carboxylic acid methyl ester 
• 319494-30-9 2,2-Dimethyl-propionic acid (2S,3R,5S)-5-benzyl-3-cyano-2-isopropyl-6-oxo-morpholin-3-ylmethyl ester 

Downstream Products

• 145552-70-1 (2S,3R)-3-[(4S,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidin-4-yl]-3-hydroxy-2-methyl-propionic acid 2,6-dimethyl-phenyl ester 
• 133343-34-7 Lactacystin 
• 145451-93-0 (4R,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidine-4-carboxylic acid methyl ester 
• 145484-22-6 (4R,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidine-4-carbaldehyde 
• 145452-01-3 [(4R,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidin-4-yl]-methanol 
• 145451-95-2 (1S,6R,7S,7aS)-7a-(tert-Butyl-dimethyl-silanyloxymethyl)-7-hydroxy-1-isopropyl-6-methyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 
• 145451-96-3 (1S,6R,7S,7aS)-7-Hydroxy-1-isopropyl-6-methyl-5-oxo-dihydro-pyrrolo[1,2-c]oxazole-7a-carboxylic acid 
• 145451-97-4 (3R,4S,5R,1'S)-4-hydroxy-5-(1'-hydroxy-2'-methylpropyl)-3-methylpyrrolidin-2-one-5-carboxylic acid 
• 145452-02-4 (1S,6R,7S,7aS)-7-Hydroxy-7a-hydroxymethyl-1-isopropyl-6-methyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 
• 145452-03-5 (1S,6R,7S,7aS)-7-Hydroxy-1-isopropyl-6-methyl-5-oxo-dihydro-pyrrolo[1,2-c]oxazole-7a-carbaldehyde 

Relevant articles and documents

Asymmetric Strecker route toward the synthesis of the Corey intermediate of lactacystin

An efficient synthesis of Corey's precursor (2) of lactacystin has been accomplished by the use of asymmetric Strecker synthesis of α-acyloxyketone 4 having L-Phe as a chirality transferring group.