1459754-40-5

Basic information

• Product Name: (2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone
• Synonyms: (2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone
• CAS NO: 1459754-40-5
• Molecular Weight: 358.563
• Mol File: 1459754-40-5.mol

Chemical Properties

• CAS DataBase Reference: (2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone(1459754-40-5)
• EPA Substance Registry System: (2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone(1459754-40-5)

Safety Data

• Hazardous Substances Data: 1459754-40-5(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry Research:
(2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone is used as a research compound for studying organic chemistry reactions and mechanisms. Its unique structure and reactivity make it a valuable tool for understanding and developing new chemical processes.
Used in Pharmaceutical Development:
(2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone is used as a building block in the synthesis of pharmaceutical compounds. Its aromatic properties and reactivity contribute to the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
(2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone is used as a key intermediate in the synthesis of various organic compounds. Its versatility and reactivity make it an important component in the production of a wide range of chemical products.
It is important to handle and store (2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone with extreme caution, as it can be harmful if ingested, inhaled, or allowed to come into contact with the skin. Proper safety protocols and protective equipment should be used when working with this compound to minimize the risk of exposure and potential harm to individuals and the environment.

Upstream product

• 19094-56-5 2-chloro-5-iodobenzoic acid 
• 108-95-2 phenol 
• 1103738-26-6 (2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone 
• 103-73-1 Phenetole 
• 1459754-39-2 (2-chloro-5-iodophenyl)(4-methoxyphenyl)methanone 
• 281652-58-2 2-chloro-5-iodobenzoylchloride 

Downstream Products

• 915095-87-3 (S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone 
• 915095-94-2 (3S)-3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran 
• 864070-44-0 empagliflozin 
• 1459754-32-5 4-(2-chloro-5-iodobenzyl)phenol 
• 912917-83-0 (3R,4S,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol 
• 864070-37-1 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 1204220-63-2 (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol 

Relevant articles and documents

Design, synthesis and anticancer activities of halogenated Phenstatin analogs as microtubule destabilizing agent

A series of halogenated Phenstatin analogs were designed as microtubule destabilizing agent by docking study. It was synthesized within three steps starting from 2-chloro-5-iodobenzoic acid and substituted benzene. All the products were characterized by 1H NMR and 13C NMR spectral analysis, and the stereochemical structure was also confirmed by a single crystal X-ray diffraction crystallographic analysis. The microtubule destabilizing activities were evaluated in vitro with human liver cancer Huh-7 cell line and human lung cancer A549 cell line. Some of the HPAs were achieved IC50 about 5.0 μM against human liver cancer Huh-7 cells. [Figure not available: see fulltext.].

SOLID STATE FORMS OF EMPAGLIFLOZIN

The present invention provides solid state forms of empagliflozin, complexes of empagliflozin with amino acids, processes for their preparation and their use in purification of empagliflozin and also provided pharmaceutical compositions comprising them and their use in therapy (Formula I).

Preparation method of Jardiance

The invention discloses a preparation method of Jardiance. The preparation method comprises the following steps: (1) performing a Grignard exchange reaction on a compound 5, then enabling the compound 5 after the Grignard exchange reaction to react with a glucose lactone derivative 6 so as to obtain a compound 7 (as shown in the description), wherein X is bromine or iodine, LG is chlorine, bromine, mesyloxy or tosyl, and PG is acetyl, tert- butanoyl or benzoyl; (2) under the action of alkali, performing deprotection on the compound 7 so as to obtain a finished product namely an Jardiance type compound 8 (as shown in the description). The preparation route is simple to operate, the reaction steps are reduced, the yield is high, the obtained product is high in purity, and the preparation method is suitable for scaled production.