cas 146198-68-7, 2-(4-FLUORO-BENZOYL)-3-OXO-BUTYRIC ACID ETHYL ESTER | Articles data ｜lookchem

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146198-68-7

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PYRROLOPYRIDAZINE DERIVATIVES
The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
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Page 53

(2008/06/13)

Synthesis of 3-aroyltetramic acids
Recently many dienoyl tetramic acids 5 have shown interesting antimicrobial properties and a moderate inhibition of DNA-gyrase. By structural analogy we synthesized some 3-aroyltetramic acids 6; however, they did not show any activity neither against DNA-gyrase nor against Gram positive or negative bacteria.
Tranquillini
p. 1323 - 1333
(2007/10/02)

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Chemical Properties

Boiling Point: 336.6±27.0 °C(Predicted)
Density: 1.208±0.06 g/cm3(Predicted)
PKA: 5.85±0.27(Predicted)
PSA: 60.44000
LogP: 1.77670

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