147539-21-7

Basic information

• Product Name: 3-PYRIDYLAMINE, N-(1-METHYLETHYL)-2-(1-PIPERAZINYL)-,DIHYDROCHLORIDE MONOHYDRATE
• Synonyms: 3-PYRIDYLAMINE, N-(1-METHYLETHYL)-2-(1-PIPERAZINYL)-,DIHYDROCHLORIDE MONOHYDRATE;N-(1-Methylethyl)-2-(1-Piperazinyl)-3-Pyridinamine;ISOPROPYL[2-(PIPERAZIN-1-YL)-3-PYRIDYL]AMINE;3-PYRIDINAMINE,N-(1-METHYLETHYL)-2-(1-PIPERAZINYL)-;dihydrochloride,monohydrate;N-Isopropyl[2-(piperazin-1-yl)-3-pyridyl]amine;3-Pyridinamine, N-(1-methylethyl)-2-(1-piperazinyl-), dihydrochloride,monohydrate
• CAS NO: 147539-21-7
• Molecular Formula: C₁₂H₂₀N₄
• Molecular Weight: 220.314
• Mol File: 147539-21-7.mol

Chemical Properties

• Boiling Point: 392.0±37.0 °C(Predicted)
• Appearance: /
• Density: 1.080±0.06 g/cm3(Predicted)
• PKA: 9.17±0.30(Predicted)
• CAS DataBase Reference: 3-PYRIDYLAMINE, N-(1-METHYLETHYL)-2-(1-PIPERAZINYL)-,DIHYDROCHLORIDE MONOHYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PYRIDYLAMINE, N-(1-METHYLETHYL)-2-(1-PIPERAZINYL)-,DIHYDROCHLORIDE MONOHYDRATE(147539-21-7)
• EPA Substance Registry System: 3-PYRIDYLAMINE, N-(1-METHYLETHYL)-2-(1-PIPERAZINYL)-,DIHYDROCHLORIDE MONOHYDRATE(147539-21-7)

Safety Data

• Hazardous Substances Data: 147539-21-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
3-Pyridylamine, N-(1-methylethyl)-2-(1-piperazinyl)-, dihydrochloride monohydrate is used as a chemical compound in pharmaceutical research and development for its potential applications in various therapeutic areas.
Used in Central Nervous System Disorders:
In the pharmaceutical industry, 3-Pyridylamine, N-(1-methylethyl)-2-(1-piperazinyl)-, dihydrochloride monohydrate is used as a potential therapeutic agent for the treatment of central nervous system disorders.
Used in Inflammation:
3-Pyridylamine, N-(1-methylethyl)-2-(1-piperazinyl)-, dihydrochloride monohydrate is used as an anti-inflammatory agent in the development of medications to treat inflammatory conditions.
Used in Oncology:
In the field of oncology, 3-Pyridylamine, N-(1-methylethyl)-2-(1-piperazinyl)-, dihydrochloride monohydrate is used as a potential anticancer agent for the development of cancer treatments.
Used as an Analgesic Agent:
3-Pyridylamine, N-(1-methylethyl)-2-(1-piperazinyl)-, dihydrochloride monohydrate is used as a potential analgesic agent in the development of pain relief medications.
Used as an Antipsychotic Agent:
In the psychiatric field, 3-Pyridylamine, N-(1-methylethyl)-2-(1-piperazinyl)-, dihydrochloride monohydrate is used as a potential antipsychotic agent for the development of medications to treat psychiatric disorders.

InChI:InChI=1/C12H20N4.2ClH.H2O/c1-10(2)15-11-4-3-5-14-12(11)16-8-6-13-7-9-16;;;/h3-5,10,13,15H,6-9H2,1-2H3;2*1H;1H2

Upstream product

• 110-85-0 piperazine 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 111669-25-1 1-[1,1-dimethylethoxycarbonyl]-4-[3-amino-2-pyridinyl]piperazine 
• 153473-24-6 1-tert-butoxycarbonyl-4-(3-nitro-2-pyridyl)piperazine 
• 87394-48-7 1-(3-nitro-2-pyridinyl)piperazine 
• 136818-14-9 1-[1,1-Dimethylethoxycarbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine 

Downstream Products

• 136816-76-7 1-(indolyl-2-carbonyl)-4-<3-<(1-methylethyl)amino>pyridyl>-piperazine 
• 136817-55-5 delavirdine 
• 136816-97-2 1-[5-hydroxyindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine 
• 136816-84-7 1-<(5-fluoroindol-2-yl)carbonyl>-4-<3-<(methylethyl)amino>-2-pyridyl>piperazine 
• 136816-95-0 1-[5-Benzyloxyindolyl-2-carbonyl]-4-[3-(1-methylethyl)amino-2-pyridinyl]piperazine 
• 147920-10-3 (6-Benzyloxy-1H-indol-2-yl)-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 138863-11-3 1-[4-Methoxyindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine 
• 136817-59-9 delavirdine 
• 1316754-35-4 2-(4-((1-benzyl-2-[⁽¹⁴⁾C]-imidazol-5-yl)methyl)piperazin-1-yl)-N-isopropylpyridin-3-amine 
• 1316754-33-2 1-(1-benzyl-2-[⁽¹⁴⁾C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine 
• 1316754-32-1 2-(4-((1-benzyl-2-(methylthio)-2-[⁽¹⁴⁾C]-imidazol-5-yl)methyl)-piperazin-1-yl)-N-isopropylpyridin-3-amine 
• 1316754-21-8 1-(1-benzyl-2-methylthio-2-[⁽¹⁴⁾C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine 
• 136817-51-1 1-[4-Methylindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2pyridinyl]piperazine 
• 403502-46-5 [5-(4-amino-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 

Relevant articles and documents

Oligomer modified diaromatic substituted compounds

Disclosed are compounds comprising diaromatic substituted compound residues, namely the anti-viral (anti-HIV) drug delavirdine, covalently attached via a linkage to water-soluble, non-peptidic oligomers, specifically to poly(ethylene glycol) (PEG) oligome

Strategy for 14C-labeling of a series of bis(heteroaryl) piperazines

Four bis(heteroaryl)piperazines labeled with carbon-14 in the 2-position of imidazole moiety were prepared as part of a 4-step (or 5-step) sequence from 5-hydroxymethyl-2-mercapto-1-benzylimida-zole-[2-14C] as a key synthetic intermediate which

Synthesis and anti-HIV-1 activity of new delavirdine analogues carrying arylpyrrole moieties

In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 14 delavirdine analogues were synthesized and evaluated as potential anti-HIV-1 agents in cell-based assays. Compound 1Aa exhibited potent and selective anti-HIV-1 activity in acutely infected MT4 cells, with effective concentration (EC50) values in the submicromolar range.

Anti-aids piperazines

The present invention includes diaromatic substituted heterocyclic compounds (III) STR1 which are useful in treating individuals infected with the HIV virus. The invention includes certain previously generically disclosed anti-AIDS piperazinyl compounds (V) and a method of treating HIV infected individuals with the indoles of formula (V) and the anti-AIDS amines (X).

Discovery, synthesis, and bioactivity of bis(heteroaryl)piperazines. 1. A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors

A variety of analogues of 1-[4-methoxy-3,5-dimethylbenzyl]-4-[3- (ethylamino)-2-pyridyl]piperazine hydrochloride (U-80493E) were synthesized and evaluated for their inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Replacement of the substituted aryl moiety with various substituted indoles provided bis(heteroaryl)piperazines (BHAPs) that were 10-100-fold more potent than U-80493E. The pyridyl portion of the lead molecule was found to be very sensitive to modifications. Extensive preclinical evaluations of several of these compounds led to the selection of 1-[(5-methoxyindol-2-yl)carbonyl]-4-[3-(ethylamino)-2- pyridyl]piperazine methanesulfonate (U-87201E, atevirdine mesylate) for clinical evaluation.