147578-43-6

Basic information

• Product Name: Benzoic acid, 2-(2-methylpropoxy)-
• Synonyms: 2-Isobutoxybenzoic acid
• CAS NO: 147578-43-6
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.2271
• Mol File: 147578-43-6.mol

Chemical Properties

• Boiling Point: 313.257 °C at 760 mmHg
• Flash Point: 119.087 °C
• Density: 1.104 g/cm3
• CAS DataBase Reference: Benzoic acid, 2-(2-methylpropoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(2-methylpropoxy)-(147578-43-6)
• EPA Substance Registry System: Benzoic acid, 2-(2-methylpropoxy)-(147578-43-6)

Safety Data

• Hazardous Substances Data: 147578-43-6(Hazardous Substances Data)

Upstream product

• 119-36-8 methyl salicylate 
• 54514-31-7 1-bromo-2-isobutoxybenzene 
• 124-38-9 carbon dioxide 
• 147578-45-8 2-chloro-6-isobutoxybenzoic acid 
• 21018-09-7 methyl 2-(isobutyloxy)benzoate 
• 78-83-1 2-methyl-propan-1-ol 
• 94-36-0 dibenzoyl peroxide 

Downstream Products

• 268564-38-1 methyl 2-(2-isobutoxyphenyl)acetate 
• 503809-63-0 8-(2-isobutoxy-phenyl)-3-isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione 

Relevant articles and documents

Thermodynamic properties of isomeric iso-butoxybenzoic acids: Experimental and theoretical study

Standard (p° = 0.1 MPa) molar enthalpies of formation at the temperature T = 298.15 K of the 2-, 3-, and 4-iso-butoxybenzoic acids were measured using the combustion calorimetry. Standard molar enthalpies of vaporization and sublimation were derived from

MODIFIED PROTEINS AND PROTEIN DEGRADERS

Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

NOVEL COMPOUNDS AND MEDICINAL USE THEREOF

A compound comprising the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, said atoms constitute the pharmacophore represented by the following formula: wherein Nsu

Method for producing o-alkoxybenzoic acid

o-Methoxy benzoic acid is produced by reacting chlorobenzoic acids having at least one chlorine atom at least at the ortho position with lower alcohol in the presence of a copper salt and a lower alkyl as a catalyst under moderate reaction conditions. o-Methoxy benzoic acid is useful as an intermediate for pharmaceutical, agricultural chemicals, and the like.

Cyclic Nucleotide Phosphodiesterase Inhibition by Imidazopyridines: Analogues of Sulmazole and Isomazole as Inhibitors of the cGMP Specific Phosphodiesterase

The synthesis and phosphodiesterase (PDE) inhibitory profile of a series of imidazopyridines, including sulmazole and isomazole, on separated PDE isoenzymes are described.The results show that both sulmazole and isomazole are weak inhibitors of PDE III, and their inotropic activity is unlikely to be due to PDE III inhibition alone.Surprisingly, both compounds were found to be significant inhibitors of the cGMP specific isoenzyme, PDE V, and a series of simple 2-substituted phenylimidazopyridines have been made to investigate the SAR of PDE activity.This has been shown to be sensitive to chain length, polarity, and the nature of the heteroatom linking group.Potent PDE V inhibitors, many of which are also significant inhibitors of PDE IV, have been identified.