- Fast Pd- and Pd/Cu-catalyzed direct C - H arylation of cyclic nitrones. Application to the synthesis of enantiopure quaternary α-amino esters
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Cocatalysis by pivalic acid or copper bromide allows a very fast, clean, and high-yielding palladium-catalyzed coupling of a large array of aryl, thienyl, and pyridyl halides with cyclic nitrones, including DMPO. The study of the reaction conditions, scope, and mechanism is presented. Applied to the chiral nitrone MiPNO, this transformation provides a straightforward access to enantiopure a-methyl α-arylglycine esters.
- Demory, Emilien,Farran, Daniel,Chavant, Pierre Y.,Blandin, Veronique,Baptiste, Benoit
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p. 7901 - 7912,12
(2020/10/15)
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- Synthesis and reactivity study of two new dihydroisoquinoline-derived oxaziridines
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The N-alkyl oxaziridines may be used as reagents for the oxidation of sulfides in acid-promoted reactions. The present work describes the behavior of two newly synthesized dihydroisoquinoline-derived oxaziridines with respect to methanesulfonic acid. An isomerization reaction was observed in the absence of sulfide.
- Kammoun, Majed,Salah, Hassen Ben,Damak, Mohamed
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p. 1520 - 1528
(2011/06/17)
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- Synthesis and radical scavenging activity of 3,3-dialkyl-3,4-dihydro-isoquinoline 2-oxides
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The syntheses and antioxidant activities of several cyclic nitrones related to phenyl t-butyl nitrone (PBN) are described. These nitrones may act as radical scavengers and have potential uses in the treatment of stroke and septic shock. Copyright
- Bernotas, Ronald C.,Thomas, Craig E.,Carr, Albert A.,Nieduzak, Thaddeus R.,Adams, Ginette,Ohlweiler, David F.,Hay, David A.
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p. 1105 - 1110
(2007/10/03)
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