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Methyl 4-chloro-2-fluoro benzoate is an organic compound characterized by the presence of a methyl group, a 4-chloro-2-fluoro benzoyl group, and an ester functional group. The 4-chloro-2-fluoro substitution on the benzene ring endows the compound with unique physical and chemical properties, making it a versatile intermediate for the synthesis of pharmaceuticals and agrochemicals.

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  • 148893-72-5 Structure
  • Basic information

    1. Product Name: Methyl4-chloro-2-fluoroBenzoate
    2. Synonyms: 2-fluoro-4-Chlorobenzoic acid methyl ester
    3. CAS NO:148893-72-5
    4. Molecular Formula: C8H6ClFO2
    5. Molecular Weight: 188.58
    6. EINECS: N/A
    7. Product Categories: blocks;Carboxes
    8. Mol File: 148893-72-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 228.4 °C at 760 mmHg
    3. Flash Point: 96.1 °C
    4. Appearance: /
    5. Density: 1.314 g/cm3
    6. Vapor Pressure: 0.0736mmHg at 25°C
    7. Refractive Index: 1.51
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. CAS DataBase Reference: Methyl4-chloro-2-fluoroBenzoate(CAS DataBase Reference)
    11. NIST Chemistry Reference: Methyl4-chloro-2-fluoroBenzoate(148893-72-5)
    12. EPA Substance Registry System: Methyl4-chloro-2-fluoroBenzoate(148893-72-5)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 148893-72-5(Hazardous Substances Data)

148893-72-5 Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-chloro-2-fluoro benzoate is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique substitution pattern on the benzene ring allows for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
Methyl 4-chloro-2-fluoro benzoate is utilized as a building block in the production of insecticides. Methyl4-chloro-2-fluoroBenzoate's specific properties contribute to the effectiveness of these agrochemicals in controlling pests and protecting crops.
It is crucial to handle and use Methyl 4-chloro-2-fluoro benzoate with care, adhering to proper safety protocols and regulations to ensure the safety of both the environment and individuals involved in its production and application.

Check Digit Verification of cas no

The CAS Registry Mumber 148893-72-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,8,9 and 3 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 148893-72:
(8*1)+(7*4)+(6*8)+(5*8)+(4*9)+(3*3)+(2*7)+(1*2)=185
185 % 10 = 5
So 148893-72-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H6ClFO2/c1-12-8(11)6-3-2-5(9)4-7(6)10/h2-4H,1H3

148893-72-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 4-chloro-2-fluorobenzoate

1.2 Other means of identification

Product number -
Other names methyl 4-chloro-2-fluorobenzoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:148893-72-5 SDS

148893-72-5Relevant articles and documents

Preparation method of benzothiazepine oxide, product prepared by preparation method and application of product

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Paragraph 0058; 0063-0065; 0093; 0100, (2020/08/30)

The invention discloses a preparation method of a benzothiazepine oxide, a product prepared by the preparation method and application of the product, and relates to the technical field of chemical synthesis. The method comprises the following steps: takin

Aminoheteroaryl benzamides as kinase inhibitors

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Page/Page column 355; 356; 357, (2016/02/15)

The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

Chemoselectivity of cobalt-catalysed carbonylation-A reliable platform for the synthesis of fluorinated benzoic acids

Boyarskiy, Vadim P.,Fonari, Marina S.,Khaybulova, Tatiana S.,Gdaniec, Maria,Simonov, Yurii A.

experimental part, p. 81 - 85 (2010/03/04)

The cobalt-catalysed methoxycarbonylation of polysubstituted bromo,fluoro- and chloro,fluorobenzenes and 1,2,4-trichlorobenzene with emphasis on the chemo- and regio-selectivity of the reaction is described. The structures of isolated products of 1,4-dichloro-2-fluorobenzene carbonylation were determined by single-crystal X-ray diffraction. The fact that the fluorine substituents in the studied compounds remain intact indicates in favor of the anion-radical activation of aryl halides by a cobalt catalyst. For the first time, a universal method of preparation of the various fluorobenzoic acid derivatives from available raw materials with a good yield has been elaborated.

Selective fluorodenitration of chloronitroaromatics

Beaumont, Andrew J.,Clark, James H.,Boechat, Nubia A.

, p. 25 - 30 (2007/10/02)

Nucleophilic fluorination of chloronitrobenzenes shows a strong bias for fluorodenitration rather than halogen exchange.

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