348-59-4

Usage

Uses

Used in Chemical Synthesis:
2,5-Dichlorofluorobenzene is used as an organic synthesis intermediate for the production of various chemicals and pharmaceuticals. Its unique structure, which includes two chlorine atoms and one fluorine atom attached to a benzene ring, makes it a versatile building block in the creation of a wide range of compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,5-dichlorofluorobenzene is used as a key intermediate in the synthesis of various drugs and drug candidates. Its chemical properties allow for the formation of new bonds and the creation of complex molecular structures, which can be tailored to target specific biological pathways and diseases.
Used in Agrochemical Industry:
2,5-Dichlorofluorobenzene is also utilized in the agrochemical industry as an intermediate for the synthesis of pesticides and other crop protection agents. Its ability to form stable and effective compounds makes it a valuable component in the development of new products designed to protect crops from pests and diseases.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 2,5-dichlorofluorobenzene is employed as an intermediate for the production of various dyes and pigments. Its unique chemical structure contributes to the development of vibrant and stable colorants that can be used in a wide range of applications, from textiles to plastics and inks.
Used in Polymer Industry:
2,5-Dichlorofluorobenzene is also used in the polymer industry as a monomer or intermediate for the synthesis of polymers with specific properties. These polymers can be tailored for various applications, such as in the production of plastics, coatings, and adhesives, where their unique characteristics can provide enhanced performance and durability.

InChI:InChI=1S/C6H3Cl2F/c7-4-1-2-5(8)6(9)3-4/h1-3H

Upstream product

• 36556-50-0 2,3-dichlorofluorobenzene 
• 13656-50-3 2,5-dichloro-4-fluorobenzenesulfonyl chloride 
• 351-31-5 N-(4-chloro-3-fluorophenyl)acetamide 
• 351-28-0 N-(3-fluorophenyl)acetamide 
• 106-46-7 para-dichlorobenzene 
• 367-22-6 4-chloro-3-fluoroaniline 

Downstream Products

• 583-78-8 2,5-dichlorophenol 
• 1984-58-3 2,5-dichloroanisole 
• 2624-66-0 1,4-dichloro-2-fluoro-5-nitrobenzene 
• 13656-50-3 2,5-dichloro-4-fluorobenzenesulfonyl chloride 
• 1894-96-8 1-(2,5-dichloro-4-fluoro-phenyl)ethanone 
• 701-00-8 2,5-Dichlor-4-fluor-styrol 
• 704-08-5 Methyl-<2,5-dichlor-4-fluor-phenyl>-carbinol 
• 676517-66-1 4-[[4-(2,5-dichlorophenoxy)-1-piperidinyl]methyl]-α-phenyl-1-piperidineacetic acid 
• 1056987-14-4 C₁₈H₁₈Cl₂O₃ 
• 35989-28-7 2,5-dichloro-4-fluorobenzoic acid 
• 357406-11-2 3-[(1R)-3-Azido-1-(2,5-dichlorophenoxy)propyl]isoxazole 
• 1123307-08-3 2,5-dichloro-4-fluorobenzenesulfonic acid 
• 5292-47-7 1,4-dimethyl 2-fluorobenzene-1,4-dicarboxylate 
• 148893-72-5 4-chloro-2-fluorobenzoic acid methyl ester 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF ORGANIC HALIDES

The present invention provides a halo-de-carboxylation process for the preparation of organic chlorides, organic bromides and mixtures thereof, from their corresponding carboxylic acids, using a chlorinating agent selected from trichloroisocyanuric acid (TCCA), dichloroisocyanuric acid (DCCA), or combination thereof, and a brominating agent.

Preparation process of fluorine substituted aromatic compound

A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylamino-difluoromethane compound, for example, 2,2′-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.

Photo-Rearrangement of Polychlorobenzenes meta-Migration of Chlorine Atom

Several polychlorobenzenes were irradiated by ultraviolet light (254 nm) in acetonitrile and the products were determined by gas chromatography.In addition to the abstraction of hydrogen atom from the solvent, photo-isomerization was shown to proceed giving isomeric polychlorobenzenes one of which chlorine atoms migrated to meta to the original position.The meta-rearrangement was rationalized by an MNDO calculation on o-chlorophenyl free radical.

New Method for Selective Monofluorination of Aromatics Using Silver Difluoride

Fluorobenzene is obtained in 61percent yield from reaction of a solution of benzene in n-hexane with solid argentic fluoride (AgF2).The AgF2 acts as both a strong oxidant and the fluoride source.Cobaltic fluoride provides only low (8percent) yields of fluorobenzene under similar conditions.The predominant reaction of benzene solutions with AgF2 appears to proceed by a process involving initial electrophilic oxidative cis addition of two fluorine atoms from the solid AgF2 lattice to the para aromatic positions, leading to cis-3,6-difluoro-1,4-cyclohexadiene (F2CHD).The reductive elimination leaves solid argentous fluoride (AgF) which is easily recoverable by filtration.Elimination of HF from the F2CHD yields fluorobenzene.Reactions of haloaromatics with AgF2 generally proceed in a similar manner.Thus, further reaction of AgF2 with benzene or monohalo- or p-dihalobenzenes leads in steps to 3,3,6,6-tetrafluoro-1,4-cyclohexadiene (F4CHD) in up to 82percent yield.The modest to high yields of mono- and specific polyfluorinated aromatics contrast sharply with reported nonselective perfluorination in vapor-phase reactions of aromatics over AgF2 or CoF3.Reactions of AgF2 or CoF3 with solutions of nitrobenzene, acetophenone, benzoic acid, and benzonitrile give mixtures of o-, m-, and p-monofluoro derivatives.