446-30-0

Basic information

• Product Name: 4-Chloro-2-fluorobenzoic acid
• Synonyms: RARECHEM AL BO 0755;TIMTEC-BB SBB003797;Benzoic acid, 4-chloro-2-fluoro-;4-Chloro-2-Fluorobenzoic Acid 2-Fluoro-4-Chlorobenzoic Acid;4-CHLORO-2-FLUOROBENZOIC ACID 98%(HPL&;4-Chloro-2-Fluorobenzoic;4-Chloro-2-fluorobenzoic acid 98%;4-Chloro-2-fluorobenzoicacid98%
• CAS NO: 446-30-0
• Molecular Formula: C₇H₄ClFO₂
• Molecular Weight: 174.56
• EINECS: 207-162-3
• Product Categories: blocks;Carboxes;FluoroCompounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Fluorobenzene;API intermediates;Acids & Esters;Chlorine Compounds;Fluorine Compounds;C7;Carbonyl Compounds;Carboxylic Acids;Fluorine series
• Mol File: 446-30-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 204-208 °C(lit.)
• Boiling Point: 274.7 °C at 760 mmHg
• Flash Point: 119.9 °C
• Appearance: White to light yellow crystal powder
• Density: 1.4016 (estimate)
• Vapor Pressure: 0.00259mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.04±0.10(Predicted)
• Water Solubility: insoluble
• BRN: 973358
• CAS DataBase Reference: 4-Chloro-2-fluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-fluorobenzoic acid(446-30-0)
• EPA Substance Registry System: 4-Chloro-2-fluorobenzoic acid(446-30-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 446-30-0(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow crystal powder

Uses

4-Chloro-2-fluorobenzoic acid may be used in the following studies:As starting reagent for the synthesis of furosemide.Synthesis of 4′-chloro-2′-fluoroacetophenone.Synthesis of novel herbicidal isoxazolecarboxamides. Preparation of potential liquid crystals.

General Description

4-Chloro-2-fluorobenzoic acid is a halogen benzoic acid. It is a non-liquid crystalline carboxylic acid derivative. It has been reported to form hydrogen bonded complexes with benzoylhydrazine-based azobenzene compound. Octanol/water partition coefficient Kow of 4-chloro-2-fluorobenzoic acid has been determined by shake-flask method.

InChI:InChI=1/C7H4ClFO2/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3H,(H,10,11)/p-1

Upstream product

• 175711-83-8 4’-chloro-2’-fluoroacetophenone 
• 148893-72-5 4-chloro-2-fluorobenzoic acid methyl ester 
• 452-75-5 4-chloro-2-fluorotoluene 

Downstream Products

• 52333-65-0 2-(4-chloro-2-fluoro-phenyl)-oxazolo[4,5-b]pyridine 
• 57946-56-2 2-fluoro-4-chloroaniline 
• 71916-82-0 1-(bromomethyl)-4-chloro-2-fluorobenzene 
• 101160-87-6 1-(4-chloro-2-fluorophenyl)-2-<4-(trans-4-pentylcyclohexyl)phenyl>ethane 
• 198967-23-6 4-chloro-2-fluoro-N-methyl-N-(methyloxy)benzamide 
• 1394017-29-8 4-chloro-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-2-fluorobenzamide 
• 1428632-63-6 (S)-N-(2'-amino-3-bromo-5',6'-dihydrospiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazin]-7-yl)-4-chloro-2-fluorobenzamide 
• 625-98-9 3-chlorofluorobenzene 
• 3454-96-4 loxapine 

Relevant articles and documents

Photoinduced FeCl3-Catalyzed Alkyl Aromatics Oxidation toward Degradation of Polystyrene at Room Temperature?

While polystyrene is widely used in daily life as a synthetic plastic, the subsequently selective degradation is still very challenging and highly required. Herein, we disclose a highly practical and selective reaction for the catalytically efficient oxidation of alkyl aromatics (including 1°, 2°, and 3° alkyl aromatics) to carboxylic acids. While dioxygen was used as the sole terminal oxidant, this protocol was catalyzed by the inexpensive and readily available ferric compound (FeCl3) with irradiation of visible light (blue LEDs) under only 1 atmosphere of O2 at room temperature. This system could further facilitate the selective degradation of polystyrene to benzoic acid, providing an important and practical tool to generate high-value chemical from abundant polystyrene wastes.

Continuous synthesis method for substituted benzoic acid organic matter

The invention provides a continuous synthesis method for a substituted benzoic acid organic matter. The continuous synthesis method comprises the following steps: in the presence of a catalyst and anorganic solvent, continuously putting an organic matter of a formula (I) shown in the specification, and oxygen into a continuous reaction device, carrying out a continuous oxidation reaction so as toobtain the substituted benzoic acid organic matter, and continuously discharging the substituted benzoic acid organic matter, wherein the substituted benzoic acid organic matter is of a structure ofa formula (II) shown in the specification. Oxygen is a green reagent and is cheap and easy to obtain, a great amount of wastes are not generated after reactions are completed, and the system is easy to treat. Due to continuous reaction operation, the risk that the solvent has flash evaporation explosion because of high-concentration oxygen in in-batch reactions can be reduced. Under same oxidationconditions, due to a continuous preparation process, escape of oxygen can be reduced, the utilization rate of oxygen can be greatly increased, operation can be also simplified, the security of reactions can be improved, and the yield of the substituted benzoic acid organic matter can be increased.

Oxidation of toluenes to benzoic acids by oxygen in non-acidic solvents

Oxidation of substituted toluenes by molecular oxygen at one atmosphere to the corresponding substituted benzoic acids in non-acidic solvents was investigated. Satisfactory oxidation of halo-, methoxy-, and cyano-toluenes were achieved using Co(C18H35O2) 2/NH4Br or Co(OAc)2/NaBr/AcOH as catalysts in the presence of a radical initiator.