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6-Chloro-N-methoxy-N-methyl-nicotinamide, a chemical compound with the molecular formula C9H10ClN2O2, is a derivative of nicotinamide featuring a chlorine atom, a methoxy group, and a methyl group attached to the nicotinamide ring. 6-CHLORO-N-METHOXY-N-METHYL-NICOTINAMIDE is characterized by its unique structural features and potential applications in various fields.

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  • 149281-42-5 Structure
  • Basic information

    1. Product Name: 6-CHLORO-N-METHOXY-N-METHYL-NICOTINAMIDE
    2. Synonyms: 6-CHLORO-N-METHOXY-N-METHYL-NICOTINAMIDE;2-Chloro-5-(N-methyl-N-methoxycarbamoyl)pyridine;6-Chloro-N-methoxy-N-methylpyridine-3-carboxamide, 2-Chloro-5-[methoxy(methyl)carbamoyl]pyridine;3-Pyridinecarboxamide, 6-chloro-N-methoxy-N-methyl-
    3. CAS NO:149281-42-5
    4. Molecular Formula: C8H9ClN2O2
    5. Molecular Weight: 200.63
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 149281-42-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 365.346°C at 760 mmHg
    3. Flash Point: 174.755°C
    4. Appearance: /
    5. Density: 1.284g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.544
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: -2.16±0.10(Predicted)
    11. CAS DataBase Reference: 6-CHLORO-N-METHOXY-N-METHYL-NICOTINAMIDE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 6-CHLORO-N-METHOXY-N-METHYL-NICOTINAMIDE(149281-42-5)
    13. EPA Substance Registry System: 6-CHLORO-N-METHOXY-N-METHYL-NICOTINAMIDE(149281-42-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 149281-42-5(Hazardous Substances Data)

149281-42-5 Usage

Uses

Used in Chemical Research:
6-Chloro-N-methoxy-N-methyl-nicotinamide is utilized as a research chemical for studying its properties and potential applications in the development of new chemical compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 6-Chloro-N-methoxy-N-methyl-nicotinamide is used as a starting material for the synthesis of new drugs or as an intermediate in the development of chemical compounds with biological activity. Its unique structure and functional groups make it a promising candidate for drug discovery and design.
Used in Biological Research:
6-Chloro-N-methoxy-N-methyl-nicotinamide may possess properties that make it useful for studying biological processes and mechanisms in the body. Its interaction with biological systems can provide insights into the underlying mechanisms of various diseases and potential therapeutic targets.

Check Digit Verification of cas no

The CAS Registry Mumber 149281-42-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,2,8 and 1 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 149281-42:
(8*1)+(7*4)+(6*9)+(5*2)+(4*8)+(3*1)+(2*4)+(1*2)=145
145 % 10 = 5
So 149281-42-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H9ClN2O2/c1-11(13-2)8(12)6-3-4-7(9)10-5-6/h3-5H,1-2H3

149281-42-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-chloro-N-methoxy-N-methylpyridine-3-carboxamide

1.2 Other means of identification

Product number -
Other names 6-chloro-N-methoxy-N-methylpyridin-3-carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:149281-42-5 SDS

149281-42-5Relevant articles and documents

Direct synthesis of β-aminoketones from amides via novel sequential nucleophilic substitution/Michael reaction

Gomtsyan, Arthur

, p. 11 - 13 (2000)

(formula presented) The synthesis of β-aminoketones from amides can be achieved in a process consisting of sequential nucleophilic substitution at the carbonyl group by vinylmagnesium bromide followed by Michael reaction after quench of the first reaction

Catalytic Enantioselective Pyridine N-Oxidation

Hsieh, Sheng-Ying,Tang, Yu,Crotti, Simone,Stone, Elizabeth A.,Miller, Scott J.

, p. 18624 - 18629 (2019/11/21)

The catalytic, enantioselective N-oxidation of substituted pyridines is described. The approach is predicated on a biomolecule-inspired catalytic cycle wherein high levels of asymmetric induction are provided by aspartic-acid-containing peptides as the aspartyl side chain shuttles between free acid and peracid forms. Desymmetrizations of bis(pyridine) substrates bearing a remote pro-stereogenic center substituted with a group capable of hydrogen bonding to the catalyst are demonstrated. Our approach presents a new entry into chiral pyridine frameworks in a heterocycle-rich molecular environment. Representative functionalizations of the enantioenriched pyridine N-oxides further document the utility of this approach. Demonstration of the asymmetric N-oxidation in two venerable drug-like scaffolds, Loratadine and Varenicline, show the likely generality of the method for highly variable and distinct chiral environments, while also revealing that the approach is applicable to both pyridines and 1,4-pyrazines.

PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

-

Page/Page column 130; 131, (2018/08/04)

Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS. (I)

ISOQUINOLINE DERIVATIVES AS MGAT2 INHIBITORS

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Paragraph 0486; 0487, (2018/02/27)

The compounds of Formula I act as MGAT2 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.

Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia

Hamada, Makoto,Takayama, Tetsuo,Shibata, Tsuyoshi,Hiratate, Akira,Takahashi, Masato,Yashiro, Miyoko,Takayama, Noriko,Okumura-Kitajima, Lisa,Koretsune, Hiroko,Kajiyama, Hiromitsu,Naruse, Takumi,Kato, Sota,Takano, Hiroki,Kakinuma, Hiroyuki

supporting information, p. 1725 - 1730 (2018/04/30)

Prolyl hydroxylase domain-containing protein (PHD) inhibitors are useful as orally administered agents for the treatment of renal anemia. Based on the common structures of known PHD inhibitors, we found novel PHD inhibitor 1 with a 2-[(4-hydroxy-6-oxo-2,3

pyrrole logical sequence handkerchief nai intermediate preparation method (by machine translation)

-

Paragraph 0027-0028, (2017/07/06)

The invention relates to a simple operation, raw materials are easy, and the production cost is low, the quality of the product is good and is suitable for the industrial production of the intermediate pyrrole logical sequence handkerchief nai 5 - (pyridine - 2 - yl) - 2 (1H) - pyridone of the preparation method. (by machine translation)

SPIRO-THIAZOLONES

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Page/Page column 76, (2016/06/06)

The present invention provides spiro-thiazolones, which act as V1a receptor modulators, and in particular as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The present compounds are useful as therapeutics acting peripherally and centrally in the conditions of inappropriate secretion of vasopressin, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, aggressive behavior and phase shift sleep disorders, in particular jetlag.

One-Pot Direct Synthesis of Weinreb Amides from Aryl and Hetero Aryl Halides Using Co 2(CO) 8 as an Effective CO Source under Conventional Thermal Heating

Baburajan, Poongavanam,Elango, Kuppanagounder P.

, p. 541 - 548 (2015/10/29)

A successful protocol for the synthesis of Weinreb amides directly from aryl halides via aminocarbonylation with N,O-dimethyl hydroxylamine using Co2(CO)8 as an in situ CO source has been demonstrated. The effects of various reaction parameters such as temperature, base, and CO source have also been investigated and optimized. GRAPHICAL ABSTRACT.

PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

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Paragraph 0442; 0443, (2015/06/17)

There are provided compounds having a superior PHD2 inhibitory effect that are represented by general formula (I'): (in the above-mentioned general formula (I'), W, Y, R2, R3, R4, and Y4 are as described hereinabove), or pharmaceutically acceptable salts thereof.

HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt

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Paragraph 0320; 0321, (2014/05/07)

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

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