151831-21-9

Basic information

• Product Name: Methyl Pyrazolo[1,5-a]pyridine-2-carboxylate
• Synonyms: Methyl Pyrazolo[1,5-a]pyridine-2-carboxylate
• CAS NO: 151831-21-9
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.17202
• Mol File: 151831-21-9.mol

Chemical Properties

• Melting Point: 91-92 °C(Solv: methanol (67-56-1); ethyl acetate (141-78-6))
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• PKA: 0.07±0.30(Predicted)
• CAS DataBase Reference: Methyl Pyrazolo[1,5-a]pyridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl Pyrazolo[1,5-a]pyridine-2-carboxylate(151831-21-9)
• EPA Substance Registry System: Methyl Pyrazolo[1,5-a]pyridine-2-carboxylate(151831-21-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 151831-21-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
Methyl Pyrazolo[1,5-a]pyridine-2-carboxylate is used as a key building block for the synthesis of various pharmaceuticals and biologically active compounds. Its unique structure and properties make it a promising candidate for the development of new drugs with therapeutic potential.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, MPPC is utilized as a research tool to explore its potential in creating novel drug candidates. Its structural characteristics allow for the design and synthesis of compounds that could address unmet medical needs.
Used in Organic Chemistry:
Methyl Pyrazolo[1,5-a]pyridine-2-carboxylate is used as a chemical intermediate in organic chemistry, facilitating the synthesis of complex organic molecules and contributing to the advancement of chemical reactions and processes.
Used in Material Science:
In material science, MPPC may be employed in the development of new materials with specific properties, such as those with enhanced biological activity or improved stability, further expanding its applications beyond traditional pharmaceutical uses.
As research and development in these fields progress, MPPC and its derivatives could lead to the discovery of innovative drug candidates with significant therapeutic benefits.

Upstream product

• 67-56-1 methanol 
• 63237-88-7 pyrazolo[1,5-a]pyridine-2-carboxylic acid 
• 5825-71-8 pyrazolo<1,5-a>pyridine-2,3-dicarboxylic acid dimethyl ester 
• 1121-60-4 pyridine-2-carbaldehyde 

Relevant articles and documents

PYRIMIDONE DERIVATIVES CONTAINING TWO FUSED BICYCLIC RINGS

The invention relates to a compound of formula (I), wherein the variables are defined in the specification. It also relates to a pesticidal mixture comprising the compound of formula (I); the use of compounds of formula (I) as an agrochemical pesticide; a method for combating or controlling invertebrate pests, a method for protecting growing plants from attack or infestation by invertebrate pests, seed comprising a compound of the formula (I); the use of a compound of the formula (I) for protecting growing plants from attack or infestation by invertebrate pests; and a method for treating or protecting an animal from infestation or infection by invertebrate pests.

A Bu4N[Fe(CO)3(NO)]-Catalyzed Hemetsberger–Knittel Indole Synthesis

The nucleophilic Fe complex Bu4N[Fe(CO)3(NO)] (TBA[Fe]) catalyzes the direct intramolecular amination of aryl vinyl azides to give the corresponding indole derivatives in good to excellent yields.

Targeting human La and its precursor compound of the protein in the preparation of anti-hepatitis b virus use in medicine

The invention belongs to the field of pharmacy and relates to a lead compound of a targeting human La protein and purpose thereof in preparation of a medicament for resisting hepatitis B virus. According to the invention, research on enhancement of HBVRNA stability by the targeting La protein is employed to screen out the lead compound of the targeting human La protein shown as a formula (I), a formula (II) or a formula (III). Tests show that the lead compound has strong antiviral activity and effect of targeting the La protein. The lead compound of the present invention can be further optimized in structure and has good application prospect; and the lead compound and derivatives thereof can be used for preparation of medicament for resisting hepatitis B virus, as well as preparation of medicament targeting the La protein.

Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates

An efficient, safe and scalable procedure for the continuous flow thermolysis of azidoacrylates to yield indoles has been developed and was applied to the synthesis of related heterocycles. The scalability of the process was demonstrated in the continuous flow synthesis of a precursor to the DAAO inhibitor 4H-furo[3,2-b]pyrrole-5-carboxylic acid.

The Hemetsberger-Knittel synthesis of substituted 5-, 6-, and 7-azaindoles

A series of substituted 5-, 6-, and 7-azaindoles were prepared via the Hemetsberger-Knittel reaction. In general, better yields were obtained at higher temperatures and shorter reaction times than required for the formation of the analogous indoles, and in some cases, only decomposition occurred below a minimum temperature. The resulting templates offer up to five sites for subsequent functionalization to allow a wide range of chemical diversity. Georg Thieme Verlag Stuttgart.