152404-47-2

Basic information

• Product Name: 4-HYDROXYBENZOIC-2,3,5,6-D4 ACID
• Synonyms: 4-HYDROXYBENZOIC-2,3,5,6-D4 ACID;4-Hydroxybenzoic Acid-d4;4-Carboxyphenol-d4;p-Hydroxybenzoic Acid-d4;p-Salicylic Acid-d4;4-Hydroxybenzoic--d4 Acid
• CAS NO: 152404-47-2
• Molecular Formula: C₇H₆O₃
• Molecular Weight: 142.15
• Product Categories: Aromatics;Isotope Labelled Compounds;Aromatics, Isotope Labelled Compounds
• Mol File: 152404-47-2.mol

Chemical Properties

• Melting Point: 213-217 °C
• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-HYDROXYBENZOIC-2,3,5,6-D4 ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXYBENZOIC-2,3,5,6-D4 ACID(152404-47-2)
• EPA Substance Registry System: 4-HYDROXYBENZOIC-2,3,5,6-D4 ACID(152404-47-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 152404-47-2(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

An impurity of labelled Salicylic Acid synthesis

Upstream product

• 1079-02-3 benzoic acid-2,3,4,5,6-d5 
• 65-85-0 benzoic acid 
• 99-96-7 4-hydroxy-benzoic acid 
• 152404-45-0 4-bromo-<2,3,5,6-2H4>anisole 
• 152404-44-9 [2′,3′,5′,6′-d₄]bromophenol 
• 13127-88-3 phenol-d6 
• 152404-46-1 4-methoxy-<2,3,5,6-2H4>benzoic acid 

Downstream Products

• 152404-48-3 3,5-dibromo-4-hydroxy-<2,6-2H2>benzoic acid 
• 1192260-75-5 4-(benzyloxy)-2,3,5,6-tetradeuterobenzoic acid 
• 1219802-67-1 propyl 4-hydroxybenzoate-2,3,5,6-d₄ 
• 1219795-53-5 ethyl 4-hydroxybenzoate-2,3,5,6-d₄ 
• 362049-51-2 methyl 4-hydroxybenzoate-2,3,5,6-d₄ 
• 1219798-67-0 n-butyl 4-hydroxybenzoate-2,3,5,6-d₄ 

Relevant articles and documents

Surface-Deactivated Core–Shell Metal–Organic Framework by Simple Ligand Exchange for Enhanced Size Discrimination in Aerobic Oxidation of Alcohols

Metal–organic frameworks (MOFs) are an attractive catalyst support for stable immobilization of the active sites in their scaffold due to the high tunability of organic ligands. The active site-functionalized ligands can be easily employed to construct MOFs as porous heterogeneous catalysts. However, the existence of active sites on the external surfaces as well as internal pores of MOFs seriously impedes the selective reaction in the pore. Herein, through a simple post-synthetic ligand exchange (PSE) method we synthesized surface-deactivated (only core-active) core–shell-type MOF catalysts, which contain 2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) groups on the ligand as active sites for aerobic oxidation of alcohols. The porous but catalytically inactive shell ensured the size-selective permeability by sieving effects and induced all reactions to take place in the pores of the catalytically active core. Because PSE is a facile and universal approach, this can be rapidly applied to a variety of MOF-based catalysts for enhancing reaction selectivity.

Aqueous Oxidations Started by TiO2 Photoinduced Holes Can Be a Rate-Determining Step

In aqueous TiO2 photocatalytic hydroxylation of weakly polar aromatics, a series of inverse H/D KIEs of 0.7–0.8 were observed, which is different than the normal H/D kinetic isotope effects (KIEs) usually observed for polar aromatics. This result indicated that the oxidation started by photo-induced hvb + can be the rate-determining step.

Studies on the biosynthesis of the antibiotic reductiomycin in Streptomyces xanthochromogenus

The biosynthesis of the antibiotic reductiomycin (1) in Streptomyces xanthochromogenus was investigated by feeding experiments with radioactive and stable isotope-labeled precursors. NMR and mass spectroscopic analyses of the labeled 1 samples revealed th