1540-29-0Relevant articles and documents
Synthesis and fungicidal activities of perfluoropropan-2-yl-based novel quinoline derivatives
Zhang, Zai,Liu, Minhua,Liu, Weidong,Xiang, Jun,Li, Jianming,Li, Zhong,Liu, Xingping,Huang, Mingzhi,Liu, Aiping,Zheng, Xingliang
, p. 91 - 97 (2019)
A series of novel perfluoropropan-2-yl-based quinoline derivatives was designed and synthesized utilizing tebufloquin as the lead compound. The structures of all the newly synthesized compounds were confirmed by spectroscopic data 1HNMR, MS and elemental analysis. The results of bioassay indicated that these compounds exhibited potent fungicidal activities against Erysiphe graminis. Especially, compound 8c displayed excellent activity with EC50 value at 1.48 mg / L, which was better than that of the commercialized fungicide-tebufloquin. The structure-activity relationship for these new compounds was also discussed.
Synthetic Scope of Br?nsted Acid-Catalyzed Reactions of Carbonyl Compounds and Ethyl Diazoacetate
Rahaman, Mizzanoor,Ali, M. Shahnawaz,Jahan, Khorshada,Hinz, Damon,Belayet, Jawad Bin,Majinski, Ryan,Hossain, M. Mahmun
, p. 6138 - 6147 (2021/05/06)
The comprehensive study of the reactions of carbonyl compounds and ethyl diazoacetate in the presence of a Br?nsted acid catalyst is described. In result, a broad range of 3-oxo-esters were synthesized from a variety of ketones and aliphatic aldehydes by 1,2-aryl/alkyl/hydride shift. Aryl-methyl ketones produced only aryl-migrated products, whereas other ketones yielded a mixture of products. For diaryl ketones, the identity of two inseparable migrated products was confirmed by two-dimensional NMR spectroscopy.
Nano-K2CO3: Preparation, characterization and evaluation of reactive activities
Li, Jun-Zhang,Fan, Shi-Ming,Sun, Xuan-Fei,Liu, Shouxin
, p. 1865 - 1869 (2016/01/20)
A novel base, nano-K2CO3, was easily prepared by ultrafine wet milling. The surface properties and the reactive activities of nano-K2CO3 were characterized. It was found that such a base showed higher basicity than normal K2CO3 and could replace sodium (or potassium) alkoxide to carry out monoalkylation and oximation of active methylene compounds. The nano-K2CO3 could be regenarated and reused 10 times without loss of its reactive activity.
Rh(I)-bisphosphine-catalyzed asymmetric, intermolecular hydroheteroarylation of α-substituted acrylate derivatives
Filloux, Claire M.,Rovis, Tomislav
supporting information, p. 508 - 517 (2015/01/30)
Asymmetric hydroheteroarylation of alkenes represents a convenient entry to elaborated heterocyclic motifs. While chiral acids are known to mediate asymmetric addition of electron-rich heteroarenes to Michael acceptors, very few methods exploit transition metals to catalyze alkylation of heterocycles with olefins via a C-H activation, migratory insertion sequence. Herein, we describe the development of an asymmetric, intermolecular hydroheteroarylation reaction of α-substituted acrylates with benzoxazoles. The reaction provides 2-substitued benzoxazoles in moderate to excellent yields and good to excellent enantioselectivities. Notably, a series of mechanistic studies appears to contradict a pathway involving enantioselective protonation of a Rh(I)-enolate, despite the fact that such a mechanism is invoked almost unanimously in the related addition of aryl boronic acids to methacrylate derivatives. Evidence suggests instead that migratory insertion or beta-hydride elimination is enantiodetermining and that isomerization of a Rh(I)-enolate to a Rh(I)-heterobenzyl species insulates the resultant α-stereocenter from epimerization. A bulky ligand, CTH-(R)-Xylyl-P-Phos, is crucial for reactivity and enantioselectivity, as it likely discourages undesired ligation of benzoxazole substrates or intermediates to on- or off-cycle rhodium complexes and attenuates coordination-promoted product epimerization.
C- vs O-alkylation of 1,3-dicarbonyl compounds using microwave irradiation
Nayyar, Sandeep,Trehan, Inderraj,Kaur, Jasamrit
, p. 2342 - 2345 (2007/10/03)
The study of alkylation behaviour of 1,3-dicarbonyl compounds has been carried out with microwave radiation exposure of approximately 2 min resulting in moderate to good yields of the products.
Alkylation of malonic and acetoacetic esters in an ionic liquid
Kryshtal, Galina V.,Zhdankina, Galina M.,Zlotin, Sergei G.
, p. 57 - 58 (2007/10/03)
1-Butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]) has been used as a recyclable medium in the alkylation of malonic and acetoacetic esters with alkyl, benzyl and prenyl halides.
Benzopyranones, a method for producing them and uses therefor
-
, (2008/06/13)
Novel 2H-1-benzopyran-2-ones (coumarin derivatives) of the general formula (I) are provided: STR1 wherein R1, R2, R3, R4, X and Y are defined as in the specification, and the addition compounds thereof with physiologically compatible acids, intermediates and methods for the preparation thereof. The coumarin compounds possess a neuroprotective and anti-allergic action.
Solid-Liquid Phase Transfer Catalytic Synthesis X: The Rapid Alkylation of Ethyl Acetoacetate Under Microwave Irradiation
Runhua, Deng,Yuliang, Wang,Yaozhong, Jiang
, p. 111 - 116 (2007/10/02)
Rapid alkylation of ethyl acetoacetate with a series of halides were performed in 650W domestic microwave oven and the isolated yield of monoalkylated product varying from 59 to 82percent.
Alkylation Reactions of Ethyl Malonate, Ethyl Acetoacetate, and Acetylacetone by Gas-Liquid Phase-Transfer Catalysis (G.L.-P.T.C)
Tundo, Pietro,Venturello, Paolo,Angeletti, Enrico
, p. 2159 - 2162 (2007/10/02)
Malonyl, acetoacetyl, and acetylacetonyl alkylation reactions have been carried out in the gaseous state under gas-liquid phase-transfer catalysis (g.l-p.t.c) conditions using potassium carbonate or sodium hydrogencarbonate as the base.No alkali metal was used to generate the reactive anion.No solvents are used in the process, and the reaction mixture requires no stirring.The phase-transfer catalysts which promote the reaction: phosphonium salts, crown ethers, and poly(ethylene glycol) are also the medium in which the reaction occurs; they direct C- or O- alkylation, as a function of the methylene compound and the alkylating agent used.The malonic ester alkylation using poly(ethylene glycol) gives rise to improved selectivity for C-monoalkylation compared with the other catalysts.
