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CAS

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157698-32-3

TAMOXIFEN-ETHYL-D5, also known as Labelled Tamoxifen (T006000), is a nonsteroidal estrogen antagonist that is primarily used in the treatment of certain types of breast cancer. It is a pale brown crystalline compound with unique chemical properties that make it a valuable pharmaceutical agent. TAMOXIFEN-ETHYL-D5 functions as a protein kinase C inhibitor and has the ability to induce apoptosis in human malignant glioma cell lines, further expanding its potential applications in cancer treatment.

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  • 157698-32-3 Structure

  • Basic information

    1. Product Name: TAMOXIFEN-ETHYL-D5
    2. Synonyms: TAMOXIFEN-D5 (ETHYL-D5);TAMOXIFEN-ETHYL-D5;(Z)-1-[4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]-1,2-DIPHENYL-1-BUTENE-3,3,4,4,4-D5;N,N-dimethyl-2-[4-[(Z)-3,3,4,4,4-pentadeuterio-1,2-diphenylbut-1-enyl]phenoxy]ethanamine
    3. CAS NO:157698-32-3
    4. Molecular Formula: C26H24D5NO
    5. Molecular Weight: 376.55
    6. EINECS: 604-604-1
    7. Product Categories: Isotope Labeled Compounds;Pharmaceuticals;Protein Kinase Inhibitors and Activators
    8. Mol File: 157698-32-3.mol

  • Chemical Properties

    1. Melting Point: 95-97°C
    2. Boiling Point: 482.3°Cat760mmHg
    3. Flash Point: 140°C
    4. Appearance: /
    5. Density: 1.057g/cm3
    6. Vapor Pressure: 1.85E-09mmHg at 25°C
    7. Refractive Index: 1.582
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: TAMOXIFEN-ETHYL-D5(CAS DataBase Reference)
    11. NIST Chemistry Reference: TAMOXIFEN-ETHYL-D5(157698-32-3)
    12. EPA Substance Registry System: TAMOXIFEN-ETHYL-D5(157698-32-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 157698-32-3(Hazardous Substances Data)

157698-32-3 Usage

Uses

Used in Pharmaceutical Industry:
TAMOXIFEN-ETHYL-D5 is used as a therapeutic agent for the treatment of breast cancer. It is particularly effective against some forms of breast cancer due to its estrogen antagonist properties, which help in controlling the growth and progression of cancer cells.
TAMOXIFEN-ETHYL-D5 is also used as a protein kinase C inhibitor, which plays a crucial role in regulating various cellular processes, including cell growth and differentiation. Its ability to inhibit this enzyme contributes to its potential as a cancer treatment option.
Furthermore, TAMOXIFEN-ETHYL-D5 is used to induce apoptosis in human malignant glioma cell lines, making it a valuable tool in the fight against brain cancer. By promoting programmed cell death in cancerous cells, this compound can help in limiting the spread and severity of the disease.

Check Digit Verification of cas no

The CAS Registry Mumber 157698-32-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,6,9 and 8 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 157698-32:
(8*1)+(7*5)+(6*7)+(5*6)+(4*9)+(3*8)+(2*3)+(1*2)=183
183 % 10 = 3
So 157698-32-3 is a valid CAS Registry Number.
InChI:InChI=1/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-/i1D3,4D2

157698-32-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name N,N-dimethyl-2-[4-[(Z)-3,3,4,4,4-pentadeuterio-1,2-diphenylbut-1-enyl]phenoxy]ethanamine

1.2 Other means of identification

Product number -
Other names (E/Z)-Mammaton-d5

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:157698-32-3 SDS

157698-32-3Downstream Products

157698-32-3Relevant articles and documents

Synthesis of -tamoxifen; A Mechanistic Probe of Tamoxifen Induced Hepatic DNA Adduct Formation

Horton, Martin N.,Jarman, Michael,Potter, Gerard A.

, p. 767 - 772 (1994)

Tamoxifen which incorporates a fully deuterated ethyl group, 5-ethyl>-tamoxifen, has been synthesised in order to probe the mechanism of tamoxifen induced hepatic DNA adduct formation.The pentadeuteroethyl group was introduced into the tamoxi

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