157922-13-9

Basic information

• Product Name: (4R)-4-Propyl-2-oxazolidinone
• Synonyms: (4R)-4-Propyl-2-oxazolidinone
• CAS NO: 157922-13-9
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.15704
• Mol File: 157922-13-9.mol

Chemical Properties

• Boiling Point: 302.5±9.0 °C(Predicted)
• Appearance: /
• Density: 1.022±0.06 g/cm3(Predicted)
• PKA: 12.84±0.40(Predicted)
• CAS DataBase Reference: (4R)-4-Propyl-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-4-Propyl-2-oxazolidinone(157922-13-9)
• EPA Substance Registry System: (4R)-4-Propyl-2-oxazolidinone(157922-13-9)

Safety Data

• Hazardous Substances Data: 157922-13-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(4R)-4-Propyl-2-oxazolidinone is used as a building block for the synthesis of various bioactive compounds, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
(4R)-4-Propyl-2-oxazolidinone is used as a key component in the synthesis of agrochemicals, aiding in the creation of effective pesticides and other agricultural products.
Used in Asymmetric Synthesis:
(4R)-4-Propyl-2-oxazolidinone is used as a chiral auxiliary in asymmetric synthesis, enhancing the enantioselectivity of chemical reactions and improving the yield of desired enantiomers.
Used as a Solvent:
(4R)-4-Propyl-2-oxazolidinone has been studied for its potential as a solvent in chemical reactions, particularly where high enantioselectivity is required, facilitating more efficient and selective processes.

Upstream product

• 75-44-5 phosgene 
• 4146-04-7 DL-2-amino-1-pentanol 
• 3647-38-9 2-propyl-aziridine 
• 124-38-9 carbon dioxide 
• 38297-20-0 lithium diethylcuprate 
• 154669-49-5 [(S)-2-oxooxazolidin-4-yl]methyl-4-methylbenzenesulfonate 
• 925-90-6 ethylmagnesium bromide 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 22724-81-8 L-norvalinol 

Relevant articles and documents

Method of preparing oxazolidone

The invention discloses a method of preparing oxazolidone. The method uses aziridine and carbon dioxide as materials and imidazole ionic liquid modified Salen metal complex comprising polyether chains as a catalyst, and allows high-efficiency and high-selectivity catalytic synthesis of oxazolidone under a pressure of 0.1-2.0 Mpa at a temperature of 30-70 DEG C; the process has relatively mild reaction conditions, there is no need for any solvent or co-catalyst, and reaction time is short; in addition, the catalyst provided herein can form a homogeneous catalytic system with a substrate under certain temperature and pressure, and by adding the solvent, it is possible to separate from the reaction system to enable reuse.

SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS

Compounds of Formula I: and salts thereof in which R1, R2, R2a, R3, n, X and ring B have the meanings given in the specification, are inhibitors of mTOR and are useful in the treatment of diseases which are sensitive to inhibition of mTOR, such as cancers.

NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE

Provided are a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2, as well as a prophylactic/therapeutic drug for autoimmune diseases or osteoarthritis

A New Electrophilic Alaninol Synthon. A General Route to Oxazolidinones of D or (R)-2-Amino Alcohols from L-Serine

A new electrophilic alaninol synthon, (S)-4-(4'-tolylsulfonyloxymethyl)oxazolidin-2-one, derived from serine, undergoes nucleophilic displacements with Gilman cuprates and/or Grignard/CuX reagents in high yields to provide (R)-4-substituted oxazolidinones.