- Cationic lipid molecule, and application thereof in nucleic acid delivery
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The present invention discloses a cationic lipid molecule, and an application thereof in nucleic acid delivery. The structural formula of the cationic lipid molecule is represented by formula i. The invention further provides a cationic liposome, a lipid compound, a reagent, a kit, a preparation and a medicinal composition based on the cationic lipid molecule. The cationic lipid molecule has the advantages of simple synthesis process and good stability, and the cationic liposome has a high efficiency (characterized by high transfection efficiency) and a low toxicity, is stable and uniform, is easy to prepare, and can be used for transferring various cell lines. The cationic lipid molecule has excellent transitivity, and can efficiently deliver active substances (such as exemplary siRNA) omto cells (such as exemplary lung cancer cells), tissues and organs to achieve efficient regulation of the active substances. The problem that the toxicity and the transfer efficiency of cationic liposome existing in the prior art are low is solved.
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Paragraph 0162; 0163; 0166; 0167
(2019/10/08)
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- FREE-STANDING NON-FOULING POLYMERS, THEIR COMPOSITIONS, AND RELATED MONOMERS
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Free-standing non-fouling polymers and polymeric compositions, monomers and macromonomers for making the polymers and polymeric compositions, objects made from the polymers and polymeric compositions, and methods for making and using the polymers and polymeric compositions.
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Page/Page column 45; 47
(2017/01/23)
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- Single-molecule imaging of platinum ligand exchange reaction reveals reactivity distribution
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Single-molecule fluorescence microscopy provided information about the real-time distribution of chemical reactivity on silicon oxide supports at the solution-surface interface, at a level of detail which would be unavailable from a traditional ensemble technique or from a technique that imaged the static physical properties of the surface. Chemical reactions on the surface were found to be uncorrelated; that is, the chemical reaction of one metal complex did not influence the location of a future chemical reaction of another metal complex.
- Esfandiari, N. Melody,Wang, Yong,Bass, Jonathan Y.,Cornell, Trevor P.,Otte, Douglas A. L.,Cheng, Ming H.,Hemminger, John C.,McIntire, Theresa M.,Mandelshtam, Vladimir A.,Blum, Suzanne A.
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supporting information; experimental part
p. 15167 - 15169
(2010/12/20)
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- Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase
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The ubiquitous enzyme dUTP nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and can be considered as the first line of defence against incorporation of uracil into DNA. Inhibition of this enzyme results in over-incorporation of uraci
- McCarthy, Orla,Musso-Buendia, Alex,Kaiser, Marcel,Brun, Reto,Ruiz-Perez, Luis M.,Johansson, Nils Gunnar,Pacanowska, Dolores Gonzalez,Gilbert, Ian H.
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experimental part
p. 678 - 688
(2009/09/27)
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- INSULIN DERIVATIVES CONJUGATED WITH STRUCTURALLY WELL DEFINED BRANCHED POLYMERS
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Insulin conjugated with structurally well defined, bifurcated and trifurcated polymers can be use by pulmonary delivery for systemic absorption through the lungs to reduce or eliminate the need for administering other insulins by injection.
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Page/Page column 69
(2008/06/13)
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- DERIVATIVES OF INSULINOTROPIC AGENTS CONJUGATED WITH STRUCTURALLY WELL DEFINED BRANCHED POLYMERS
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Novel GLP-1 conjugated with structurally well defined polymers and their therapeutically use.
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Page/Page column 94
(2008/06/13)
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- Selective synthesis of carbamate protected polyamines using alkyl phenyl carbonates
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Utilising alkyl phenyl carbonates, an economical, practical and versatile method for selective Boc, Cbz and Alloc protection of polyamines has been developed. This method allows Boc, Cbz and Alloc protection of primary amines in the presence of secondary amines by reaction of the polyamines with the alkyl phenyl carbonates. Also, this method allows mono carbamate protection of simple symmetrical aliphatic α,ω-alkanediamines in high yields with respect to the diamine. Finally, the method allows selective carbamate protection of a primary amine located on a primary carbon in the presence of a primary amine located on a secondary or a tertiary carbon in excellent yields.
- Pittelkow, Michael,Lewinsky, Rasmus,Christensen, Jorn Bolstad
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p. 2195 - 2202
(2007/10/03)
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- Pseudopolyrotaxanes
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PCT No. PCT/EP97/03344 Sec. 371 Date Dec. 30, 1998 Sec. 102(e) Date Dec. 30, 1998 PCT Filed Jun. 25, 1997 PCT Pub. No. WO98/01163 PCT Pub. Date Jan. 15, 1998The invention relates to new metal complex-containing or iodine-containing benzene derivatives tha
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- Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
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Cascade polymer complexes that contain a) complexing ligands of general formula I in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of one another, stand for a direct bond or a cascade reproduction
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- Cascade polymer complexes, process for their production and pharamceutical agents containing said complexes
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Cascade polymer complexes that contain a) complexing ligands of general formula I in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of one another, stand for a direct bond or a cascade reproduction
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- Substituted DTPA monoamides of the central carboxylic acid group and their metal complexes
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Diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing an element of atomic numbers 21-29, 31, 32, 39, 42-44, 49 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and process for their production.
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- Process for the production of DTPA-tetraesters of terminal carboxylic acids
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The invention relates to a process for the production of diethylenetriaminepentacarboxylic acid tetraesters of general formula I STR1 in which R1 and Z have different meanings.
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- Synthesis of Cross-Linked Polyamines
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Several synthetic approaches are explored for the preparation of polyamines which are cross-linked at the central, secondary nitrogen moiety.Diethylenetriamine, norspermidine and spermidine were used as examples. - Keywords: Cross-Linked Polyamines, Dieth
- Sosnovsky, George,Lukszo, Jan
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p. 1580 - 1585
(2007/10/02)
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