16180-96-4

Basic information

• Product Name: 2-acetamidoethyl acetate
• Synonyms: 2-acetamidoethyl acetate;N-[2-(Acetyloxy)ethyl]acetamide;Acetamide, N-(2-(acetyloxy)ethyl)-;Einecs 240-317-3;N-(2-ACETOXYETHYL)ACETAMIDE
• CAS NO: 16180-96-4
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.15644
• EINECS: 240-317-3
• Mol File: 16180-96-4.mol

Chemical Properties

• Boiling Point: 301.1°Cat760mmHg
• Flash Point: 135.9°C
• Appearance: /
• Density: 1.059g/cm³
• Vapor Pressure: 0.00108mmHg at 25°C
• Refractive Index: 1.428
• CAS DataBase Reference: 2-acetamidoethyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetamidoethyl acetate(16180-96-4)
• EPA Substance Registry System: 2-acetamidoethyl acetate(16180-96-4)

Safety Data

• Hazardous Substances Data: 16180-96-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H11NO3/c1-5(8)7-3-4-10-6(2)9/h3-4H2,1-2H3,(H,7,8)

Upstream product

• 98553-10-7 1-acetoxy-2-acetylamino-1-ethylsulfanyl-ethane 
• 108-24-7 acetic anhydride 
• 141-43-5 ethanolamine 
• 463-51-4 Ketene 
• 127-09-3 sodium acetate 
• 19220-93-0 pentafluorophenyl acetate 
• 141-78-6 ethyl acetate 
• 142-26-7 2-acetylaminoethanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 5804-92-2 2-(trimethylsilyloxy)ethanamine 
• 17101-83-6 N-<2-Chlor-ethyl>-diacetyl-amin 

Relevant articles and documents

Method using amide ester to prepare diamine derivative

The invention provides a method using amide ester to prepare a diamine derivative. The method is characterized in that ester groups in amide esters containing both amide and ester functional groups are substituted to prepare the diamine derivative, and one of the diamine groups of the diamine derivative is carboxylic acid amide reserved from the amide ester raw materials. The method is cheap in raw material, easy in raw material obtaining, low in catalyst use amount, simple in reaction conditions and high in product stereoselectivity.

Silica-supported boric acid catalyzed synthesis of dihydropyrimidin-2-ones, bis(indolyl)methanes, esters and amides

Silica-supported boric acid (H3BO3-SiO2) has been established as a green, efficient and recyclable catalyst for the synthesis of dihydropyrimidin-2-ones, bis(indolyl)methanes, and acetylation of alcohols, phenols, amines and thiols under solvent free conditions. The main features of the present method include clean reaction, mild conditions, low loading of environment friendly catalyst and easy workup procedure. The catalyst can be recycled at least five times without any significant loss in activity.

Sulfonylation-induced N-to O -Acetyl migration in 2-acetamidoethanol derivatives

The first example of sulfonylation-induced N- to O-acetyl migration of 2-acetamidoethanol derivatives is described. This type of reaction could happen with any 2-acetamidoethanol derivatives under typical sulfonylation conditions (TsCl or MsCl, pyridine) and might be a common side reaction of significance. Furthermore, the results reveal that 2-acetamidoethanol derivatives with a sterically encumbered hydroxyl group result in the migration products in high yields. The mechanism of the migration reaction is discussed.

A Novel Series of N-(1-Aminoalkylidene)carboximidamides as Potential Hypoglycemic Agents

Nitrogen heterocyclic carboximidamides, such as linogliride, 1a, have been shown to possess significant hypoglycemic activity and have shown clinical efficacy as potential antidiabetic agents.We evaluated the biological significance of the heterocyclic ring A of general structure 1, which has always been maintained in this class of compounds, by preparing acyclic compounds of general structure 2.Preliminary in vivo biological testing, i.e., the glucose tolerance test in rats, indicates that a number of the specific acyclic carboximidamides prepared, 6a-6kk, possessed significant hypoglycemic activity often comparable to, and in some cases better than, the activity noted for our model compound, 1a.These results suggest that the heterocyclic ring A of 1 is not essential for hypoglycemic activity for this class of compounds.

Acetyl transfer reactions on AlPO4-Al2O3

An efficient acetylation of alcohols and aliphatic amines promoted by the AlPO4-Al2O3/ethyl acetate system is described.The solid catalist acts, at least in part, as the acetyl carrier.