2-Acetamidoethyl acetate

Base Information

• Chemical Name: 2-Acetamidoethyl acetate
• CAS No.: 16180-96-4
• Molecular Formula: C6H11 N O3
• Molecular Weight: 145.158
• Hs Code.: 2924199090
• European Community (EC) Number: 240-317-3
• UNII: KP9WF9WKM4
• DSSTox Substance ID: DTXSID1066021
• Nikkaji Number: J286.836I
• Wikidata: Q81992595
• Mol file: 16180-96-4.mol

Synonyms:2-Acetamidoethyl acetate;2-(acetylamino)ethyl acetate;16180-96-4;Acetamide, N-[2-(acetyloxy)ethyl]-;N-[2-(Acetyloxy)ethyl]acetamide;EINECS 240-317-3;Acetamide, N-(2-(acetyloxy)ethyl)-;N-acetoxyethylacetamide;KP9WF9WKM4;1-Acetamido-2-acetoxyethane;Ethanolamine, N,O-diacetyl-;SCHEMBL279485;2-Aminoethanol, N,O-diacetyl-;DTXSID1066021;MFCD00026208;AKOS006220500;ACETAMIDE,N-(2-(ACETYLOXY)ETHYL)-

Chemical Property of 2-Acetamidoethyl acetate

Chemical Property:

• Vapor Pressure: 0.00108mmHg at 25°C
• Boiling Point: 301.1°Cat760mmHg
• Flash Point: 135.9°C
• PSA: 58.89000
• Density: 1.059g/cm³
• LogP: 0.52590
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 145.07389321
• Heavy Atom Count: 10
• Complexity: 133

Purity/Quality:

98%Min ^*data from raw suppliers

N-(2-ACETOXYETHYL)ACETAMIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NCCOC(=O)C

Technology Process of 2-Acetamidoethyl acetate

There total 12 articles about 2-Acetamidoethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethanolamine (141-43-5) + ethyl acetate (141-78-6) → N-<2-(acetyloxy)ethyl>acetamide (16180-96-4)

Guidance literature:

With aluminum oxide; monoaluminum phosphate; at 25 ℃;

Reference yield: 56.0%

2-acetylaminoethanol (142-26-7) + acetic anhydride (108-24-7) → N-<2-(acetyloxy)ethyl>acetamide (16180-96-4)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 16h; Cooling with ice;

Reference yield: 36.0%

2-acetylaminoethanol (142-26-7) + p-toluenesulfonyl chloride (98-59-9) → N-<2-(acetyloxy)ethyl>acetamide (16180-96-4) + N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide (14316-14-4) + 1-O-acetyl-2-(tosylamido)ethanol

Guidance literature:

With pyridine; at 0 - 20 ℃;

DOI:10.1021/jo100456z

upstream raw materials:

1-acetoxy-2-acetylamino-1-ethylsulfanyl-ethane

2-acetylaminoethanol

acetic anhydride

ethanolamine

Refernces

• 1、 Kumar, Vishal,Singh, Chitra,Sharma, Upendra,Verma, Praveen K.,Singh, Bikram,Kumar, Neeraj. "Silica-supported boric acid catalyzed synthesis of dihydropyrimidin-2-ones, bis(indolyl)methanes, esters and amides". . p. 83 - 89. Retrieved 2014/02/14.
• 2、 Breslin, Henry J.,Kukla, Michael J.,Tuman, Robert W.,Rebarchak, Mary C.,Bowden, Charles R.. "A Novel Series of N-(1-Aminoalkylidene)carboximidamides as Potential Hypoglycemic Agents". . p. 1597 - 1603. Retrieved 2007/10/02.