162100-42-7

Basic information

• Product Name: 6-Chloro-5-Methyl 1H-indole
• Synonyms: 6-Chloro-5-Methyl 1H-indole
• CAS NO: 162100-42-7
• Molecular Formula: C₉H₈ClN
• Molecular Weight: 165.61952
• Mol File: 162100-42-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-Chloro-5-Methyl 1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-5-Methyl 1H-indole(162100-42-7)
• EPA Substance Registry System: 6-Chloro-5-Methyl 1H-indole(162100-42-7)

Safety Data

• Hazardous Substances Data: 162100-42-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-5-Methyl 1H-indole is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs. Its unique structure allows for the creation of molecules with specific therapeutic properties, enhancing the range of available treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 6-Chloro-5-Methyl 1H-indole serves as an intermediate in the production of agrochemicals, aiding in the development of innovative agricultural products. Its incorporation into these products can lead to improved crop protection and yield enhancement.
Used in Research and Development Laboratories:
6-Chloro-5-Methyl 1H-indole is utilized in research and development laboratories as a versatile compound for various applications. Its adaptability in chemical reactions makes it an essential tool for scientists working on the discovery and improvement of organic compounds for diverse uses.

Upstream product

• 71270-61-6 N-(3-chloro-4-methylphenyl)methanesulfonamide 
• 95-74-9 3-chloro-p-toluidine 
• 755031-80-2 5-chloro-2-iodo-4-methylaniline 

Downstream Products

• 162100-44-9 6-chloro-5-methyl-2,3-dihydro-1H-indole 
• 1359945-91-7 C₂₂H₁₇ClF₃N₃O₂ 
• 181632-25-7 SB 242084 

Relevant articles and documents

Preparation method of indoline compound

The invention discloses a preparation of indoline compound expressed by the following general formula 1; the method successfully passes through for step reactions by applying iodine monochloride, acetenyl trimethyl silane and other reaction reagents, and obtains 6-chlorine-5-methyl indoline. Relative to the prior art, the synthetic method of the indoline derivative reduces the reaction step while improves the reaction yield. Moreover, the reaction condition is gentle, and easy to control; the method is good for large-scale industrial production.

Novel and selective 5-HT(2C/2B) receptor antagonists as potential anxiolytic agents: Synthesis, quantitative structure - Activity relationships, and molecular modeling of substituted 1-(3- pyridylcarbamoyl)indolines

The synthesis, biological activity, and molecular modeling of a novel series of substituted 1-(3-pyridylcarbamoyl)indolines are reported. These compounds are isosteres of the previously published indole urea 1 (SB- 206553) and illustrate the use of aromatic disubstitution as a replacement for fused five-membered rings in the context of 5-HT(2C/2B) receptor antagonists. By targeting a region of space previously identified as sterically allowed at the 5-HT(2C) receptor but disallowed at the 5-HT(2A) receptor, we have identified a number of compounds which are the most potent and selective 5-HT(2C/2B) receptor antagonists yet reported. 46 (SB-221284) was selected on the basis of its overall biological profile for further evaluation as a novel, potential nonsedating anxiolytic agent. A CoMFA analysis of these compounds produced a model with good predictive value and in addition good qualitative agreement with both our 5-HT(2C) receptor model and our proposed binding mode for this class of ligands within that model.